未登录 Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1R Inverse Agonists Zhang, Yue-Mei; Greco, Michael; Le Blanc, Tonya; Lang, Wensheng; Kauffman, Jack; Masucci, John; Murray, William, V; Demarest, Keith; Macielag, Mark Joseph 分享 收藏
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity Zhang, Yue-Mei; Greco, Michael N.; Macielag, Mark J.; Teleha, Christopher A.; DesJarlais, Renee L.; Tang, Yuting; Ho, George; Hou, Cuifen; Chen, Cailin; Zhao, Shuyuan; Kauffman, Jack; Camacho, Raul; Qi, Jenson; Murray, William; Demarest, Keith; Leonard, James 分享 收藏
Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents Du, Fuyong; Hinke, Simon A.; Cavanaugh, Cassandre; Polidori, David; Wallace, Nathanial; Kirchner, Thomas; Jennis, Matthew; Lang, Wensheng; Kuo, Gee-Hong; Gaul, Micheal D.; Lenhard, James; Demarest, Keith; Ajami, Nadim J.; Liang, Yin; Hornby, Pamela J. 分享 收藏
Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes 发现口服有效的四氢苯并咪唑作为2型糖尿病的TGR5激动剂 Zhang, Xuqing; Wall, Mark; Sui, Zhihua; Kauffman, Jack; Hou, Cuifen; Chen, Cailin; Du, Fuyong; Kirchner, Thomas; Liang, Yin; Johnson, Dana L.; Murray, William V.; Demarest, Keith 分享 收藏
Canagliflozin: a sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes mellitus Canagliflozin: 一种用于治疗2型糖尿病的钠葡萄糖共转运蛋白2抑制剂 Rosenthal, Norm; Meininger, Gary; Ways, Kirk; Polidori, David; Desai, Mehul; Qiu, Rong; Alba, Maria; Vercruysse, Frank; Balis, Dainius; Shaw, Wayne; Edwards, Robert; Bull, Scott; Di Prospero, Nicholas; Sha, Sue; Rothenberg, Paul; Canovatchel, William; Demarest, Keith 分享 收藏
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and-2 Qi, Jenson; Lang, Wensheng; Geisler, John G.; Wang, Ping; Petrounia, Ioanna; Mai, Selyna; Smith, Charles; Askari, Hossein; Struble, Geoffrey T.; Williams, Robyn; Bhanot, Sanjay; Monia, Brett P.; Bayoumy, Shariff; Grant, Eugene; Caldwell, Gary W.; Todd, Matthew J.; Liang, Yin; Gaul, Micheal D.; Demarest, Keith T.; Connelly, Margery A. 分享 收藏
Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects Sha, S.; Devineni, D.; Ghosh, A.; Polidori, D.; Chien, S.; Wexler, D.; Shalayda, K.; Demarest, K.; Rothenberg, P. 分享 收藏
In Vivo Characterization of a Dual Adenosine A2A/A1 Receptor Antagonist in Animal Models of Parkinson's Disease Shook, Brian C.; Rassnick, Stefanie; Osborne, Melville C.; Davis, Scott; Westover, Lori; Boulet, Jamie; Hall, Daniel; Rupert, Kenneth C.; Heintzelman, Geoffrey R.; Hansen, Kristin; Chakravarty, Devraj; Bullington, James L.; Russell, Ronald; Branum, Shawn; Wells, Kenneth M.; Damon, Sandra; Youells, Scott; Li, Xun; Beauchamp, Derek A.; Palmer, David; Reyes, Mayra; Demarest, Keith; Tang, Yuting; Rhodes, Kenneth; Jackson, Paul F. 分享 收藏
Design, Synthesis, and Biological Evaluation of (2R,αS)-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inhibitor Kuo, Gee-Hong; Rano, Thomas; Pelton, Patricia; Demarest, Keith T.; Gibbs, Alan C.; Murray, William V.; Damiano, Bruce P.; Connelly, Margery A. 分享 收藏
Sustained aquaretic effect of the V2-AVP receptor antagonist, RWJ-351647, in cirrhotic rats with ascites and water retention Ros, J; Fernández-Varo, G; Muñoz-Luque, J; Arroyo, V; Rodés, J; Gunnet, JW; Demarest, KT; Jiménez, W 分享 收藏
Improvement of dyslipidemia, insulin sensitivity, and energy balance by a peroxisome proliferator-activated receptor α agonist Chen, Xiaoli; Matthews, Jay; Zhou, Lubing; Pelton, Patricia; Liang, Yin; Xu, Jun; Yang, Maria; Cryan, Ellen; Rybczynski, Philip; Demarest, Keith 分享 收藏
Pharmacological characterization of RWJ-676070, a dual vasopressin V1A/V2 receptor antagonist Gunnet, Joseph W.; Wines, Pamela; Xiang, Min; Rybczynski, Philip; Andrade-Gordon, Patricia; de Garavilla, Lawrence; Parry, Tom J.; Cheung, Wai-man; Minor, Lisa; Demarest, Keith T.; Maryanoff, Bruce E.; Damiano, Bruce P. 分享 收藏
Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists Shen, Lan; Zhang, Yan; Wang, Aihua; Sieber-McMaster, Ellen; Chen, Xiaoli; Pelton, Patricia; Xu, June Z.; Yang, Maria; Zhu, Peifang; Zhou, Lubing; Reuman, Michael; Hu, Zhiyong; Russell, Ronald; Gibbs, Alan C.; Ross, Hamish; Demarest, Keith; Murray, William V.; Kuo, Gee-Hong 分享 收藏
Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual Agonists of peroxisome proliferator-activated receptors α and δ Shen, Lan; Zhang, Yan; Wang, Aihua; Sieber-McMaster, Ellen; Chen, Xiaoli; Pelton, Patricia; Xu, Jun Z.; Yang, Maria; Zhu, Peifang; Zhou, Lubing; Reuman, Michael; Hu, Zhiyong; Russell, Ronald; Gibbs, Alan C.; Ross, Hamish; Demarest, Keith; Murray, William V.; Kuo, Gee-Hong 分享 收藏
A role for β-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release Chu, Zhi-Liang; Jones, Robert M.; He, Hongmei; Carroll, Chris; Gutierrez, Veronica; Lucman, Annette; Moloney, Molly; Gao, Hui; Mondala, Helen; Bagnol, Didier; Unett, David; Liang, Yin; Demarest, Keith; Semple, Graeme; Behan, Dominic P.; Leonard, James 分享 收藏
Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of g protein-coupled receptor 40 agonists Song, Fengbin; Lu, Songfeng; Gunnet, Joe; Xu, Jun Z.; Wines, Pam; Proost, Jef; Liang, Yin; Baumann, Chris; Lenhard, Jim; Murray, William V.; Demarest, Keith T.; Kuo, Gee-Hong 分享 收藏
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New progesterone receptor antagonists:: Phosphorus-containing 11β-aryl-substituted steroids Jiang, Weiqin; Allan, George; Fiordeliso, James J.; Linton, Olivia; Tannenbaum, Pamela; Xu, Jun; Zhu, Peifang; Gunnet, Joseph; Demarest, Keith; Lundeen, Scott; Sui, Zhihua 分享 收藏
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