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Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages Bourner, Luke A.; Chung, Linda A.; Long, Haiyan; McGettrick, Anne F.; Xiao, Junpeng; Roth, Kenneth; Bailey, Jade D.; Strickland, Marie; Tan, Bo; Cunningham, Jason; Lutzke, Barry; McGee, James; Otero, Francella J.; Gemperline, David C.; Zhang, Lin; Wang, Ying C.; Chalmers, Michael J.; Yang, Chiao-Wen; Gutierrez, Jesus A.; O'Neill, Luke A. J.; Dorsey, Frank C. 分享 收藏
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Pharmacological Evaluation of a Pegylated Urocortin-1 Peptide in Experimental Autoimmune Disease Models Heuer, Josef G.; Meyer, Catalina M.; Baker, Hana E.; Geiser, Andrea; Lucchesi, Jonathan; Xu, Daniel; Hamang, Matthew; Martin, Jennifer A.; Hu, Charlie; Roth, Kenneth D.; Thirunavukkarasu, Kannan; Alsina-Fernandez, Jorge; Ma, Yanfei L. 分享 收藏
Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes Pirro, Valentina; Roth, Kenneth D.; Lin, Yanzhu; Willency, Jill A.; Milligan, Paul L.; Wilson, Jonathan M.; Ruotolo, Giacomo; Haupt, Axel; Newgard, Christopher B.; Duffin, Kevin L. 分享 收藏
Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution Broussard, Josiane L.; Perreault, Leigh; Macias, Emily; Newsom, Sean A.; Harrison, Kathleen; Bui, Hai Hoang; Milligan, Paul; Roth, Kenneth D.; Nemkov, Travis; D'Alessandro, Angelo; Brozinick, Joseph T.; Bergman, Bryan C. 分享 收藏
LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML) Salama, Vivian; Brooks, Nathan; Skwarska, Anna; Kays, Lisa; Milligan, Paul; Newell, Katherine; Roth, Kenneth; Geeganage, Sandaruwan; Gilmour, Raymond; Chan, Steven M.; Sarry, Jean-Emmanuel; Sabatier, Mary; DiNardo, Courtney; Konopleva, Marina 分享 收藏
Nucleotides released from palmitate-activated murine macrophages attract neutrophils Tam, Theresa H.; Chan, Kenny L.; Boroumand, Parastoo; Liu, Zhi; Brozinick, Joseph T.; Bui, Hai Hoang; Roth, Kenneth; Wakefield, C. Brent; Penuela, Silvia; Bilan, Philip J.; Klip, Amira 分享 收藏
The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy Schaer, David A.; Geeganage, Sandaruwan; Amaladas, Nelusha; Lu, Zhao Hai; Rasmussen, Erik R.; Sonyi, Andreas; Chin, Darin; Capen, Andrew; Li, Yanxia; Meyer, Catalina M.; Jones, Bonita D.; Huang, Xiaodong; Luo, Shuang; Carpenito, Carmine; Roth, Kenneth D.; Nikolayev, Alexander; Tan, Bo; Brahmachary, Manisha; Chodavarapu, Krishna; Dorsey, Frank C.; Manro, Jason R.; Doman, Thompson N.; Donoho, Gregory P.; Surguladze, David; Hall, Gerald E.; Kalos, Michael; Novosiadly, Ruslan D. 分享 收藏
Tryptophan Metabolism Plays a Central Role in Immunosuppression Geeganage, Sandaruwan; Sams, Lillian; Henry, James; Dorsey, Frank; Roth, Kenneth; Nikolayev, Alexander; Benhadji, Karim; Gilmour, Raymond; Cerezo, Ana; Peregrina, Sandra; Martinez-del Hoyo, Gloria; Campos-Olivas, Ramon; Manuel Funes, Juan; Diezma, Laura; Velasco-Miguel, Susana 分享 收藏
Identification and characterization of LY3410738, a novel covalent inhibitor of cancer-associated mutant Isocitrate Dehydrogenase 1 (IDH1) Brooks, Nathan; DeWalt, Robin; Boulet, Serge; Lu, ZhaoHai; Kays, Lisa; Cavitt, Rachel; Gomez, Sandra; Strelow, John; Milligan, Paul; Roth, Kenneth; Bauer, Renato; Antonysamy, Stephen; Hahn, Patric; Rankovic, Zoran; McCann, Denis; Mo, Gary; Tiu, Ramon; Burkholder, Timothy; Geeganage, Sandaruwan; Gilmour, Raymond 分享 收藏
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2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity (vol 293, pg 18328, 2018) Lou, Bin; Liu, Qi; Hou, Jiahui; Kabir, Inamul; Liu, Peipei; Ding, Tingbo; Dong, Jibin; Mo, Mingguang; Ye, Deyong; Chen, Yang; Bui, Hai H.; Roth, Kenneth; Cao, Yu; Jiang, Xian-Cheng 分享 收藏
2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity 2-羟基油酸不激活鞘磷脂合酶活性 Lou, Bin; Liu, Qi; Hou, Jiahui; Kabir, Inamul; Liu, Peipei; Ding, Tingbo; Dong, Jibin; Mo, Mingguang; Ye, Deyong; Chen, Yang; Bui, Hai H.; Roth, Kenneth; Cao, Yu; Jiang, Xian-Cheng 分享 收藏
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models Brooks, Harold B.; Meier, Timothy, I; Geeganage, Sandaruwan; Fales, Kevin R.; Thrasher, Kenneth J.; Konicek, Susan A.; Spencer, Charles D.; Thibodeaux, Stefan; Foreman, Robertt; Hui, Yu-Hua; Roth, Kenneth D.; Qian, Yue-Wei; Wang, Tao; Luo, Shuang; Torrado, Alicia; Si, Chong; Toth, James L.; Mc Cowan, Jefferson R.; Frimpong, Kwame; Lee, Matthew R.; Dally, Robert D.; Shepherd, Timothy A.; Durham, Timothy B.; Wang, Yong; Wu, Zhipei; Iversen, Philip; Njoroge, F. George 分享 收藏
Use of Plasma Metabolomics and Lipidomics for the Diagnosis of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Bril, Fernando; Kalavalapalli, Srilaxmi; Duffin, Kevin L.; Hartman, Mark L.; Chen, Yu; Yang, Qian; Haas, Joseph V.; Milligan, Paul L., Jr.; Roth, Kenneth D.; Cusi, Kenneth 分享 收藏
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model Fales, Kevin R.; Njoroge, F. George; Brooks, Harold B.; Thibodeaux, Stefan; Torrado, Alicia; Si, Chong; Toth, James L.; Mc Cowan, Jefferson R.; Roth, Kenneth D.; Thrasher, Kenneth J.; Frimpong, Kwame; Lee, Matthew R.; Dally, Robert D.; Shepherd, Timothy A.; Durham, Timothy B.; Margolis, Brandon J.; Wu, Zhipei; Wang, Yong; Atwell, Shane; Wang, Jing; Hui, Yu-Hua; Meier, Timothy I.; Konicek, Susan A.; Geeganage, Sandaruwan 分享 收藏
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