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Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits Frankel, Nicholas W.; Deng, Han; Yucel, Gozde; Gainer, Marcus; Leemans, Nelia; Lam, Alice; Li, Yongshuai; Hung, Michelle; Lee, Derrick; Lee, Chen -Ting; Banicki, Andrew; Tian, Mengxi; Almudhfar, Niran; Naitmazi, Lawrence; Roguev, Assen; Lee, Seunghee; Wong, Wilson; Gordley, Russell; Lu, Timothy K.; Garrison, Brian S. 分享 收藏
Preclinical data supporting the Phase 1 trial design of SENTI-202, a next generation allogeneic logic-gated selective CAR NK cell therapy, engineered to overcome key limitations of first generation cell therapies in AML Kaveri, Deepika; Chinta, Pearley; Leitner, Elizabeth; Naitmazi, Lawrence; Yucel, Gozde; Tian, Mengxi; Almudhfar, Niran; Deng, Han; Li, Yongshuai; Lam, Alice; Lee, Chen-Ting; Hong, Enping; Emery, Rochelle; Garrison, Brian; Nguyen, Aaron N.; Rajangam, Kanya 分享 收藏
Off-the-Shelf CAR-NK cells engineered to express calibrated release IL-15 exhibit enhanced persistence and anti-tumor activities Lee, Chen-Ting; Hung, Michelle; Banicki, Andrew; Song, Wenqi; Almudhfar, Niran; Kaveri, Deepika; Wong, Priscilla; Naitmazi, Lawrence; Guzman, Marcela; Lam, Alice; Yucel, Gozde; Lu, Timothy; Junca, Alba G.; Garrison, Brian; Lee, Philip 分享 收藏
Preclinical development of SENTI-202, an off-the-shelf logic gated CAR-NK cell therapy, for the treatment of CD33/FLT3+hematologic malignancies including AML Gonzalez, Alba; Hong, Enping; Yucel, Gozde; Leitner, Elizabeth; Chinta, Pearley; Deng, Han; Li, Ian; Lam, Alice; Bakir, Abla; Lee, Brandon; Chakraborty, Papia; Blanco, Carmina; Lee, Chen-Ting; Almudhfar, Niran; Tian, Mengxi; Song, Wenqi; Banicki, Andrew; Contreras, Otto; Gieldin, Martin; Garrison, Brian; Lu, Timothy K.; Rajangam, Kanya 分享 收藏
Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity Byun, Jun-Kyu; Lee, Sun Hee; Moon, Eui Jung; Park, Myo-Hyeon; Jang, Hyeonha; Weitzel, Douglas H.; Kim, Hyun-Hwi; Basnet, Nikita; Kwon, Do-Yeon; Lee, Chen-Ting; Stephenson, Tesia N.; Jeong, Ji-Hak; Patel, Bhargav A.; Park, Sung Jean; Chi, Jen-Tsan; Dewhirst, Mark W.; Hong, Jiyong; Lee, You Mie 分享 收藏
SENTI-401, AN ALLOGENEIC LOGIC-GATED AND MULTIARMED CAR-NK CELL THERAPY FOR THE TREATMENT OF CEA-EXPRESSING SOLID TUMORS WITH ENHANCED SELECTIVITY AND EFFICACY Junca, Alba Gonzalez; Frankel, Nicholas; Morvan, Maelig; Roguev, Assen; Hung, Michelle; Gordley, Russell; Palermo, Miguel; Santomaso, Tyler; Chinta, Pearley; Sotelo, Aldo; Gainer, Marcus; Lee, Derrick; Hua, Tony; Banicki, Andrew; Tian, Mengxi; Almudhfar, Niran; Contreras, Atahualpa; Lee, Chen-Ting; Lu, Timothy 分享 收藏
DEVELOPMENT OF LOGIC GATED CAR-NK CELLS FOR THE TREATMENT OF SOLID TUMORS Junca, Alba Gonzalez; Frankel, Nicholas; Gainer, Marcus; Mullenix, Alyssa; Palermo, Miguel; Lee, Derrick; Liu, Frances; Gordley, Russell; Lee, Chen-Ting; Roguev, Assen; Almudhfar, Niran; Tian, Mengxi; Lee, Gary 分享 收藏
SENTI-101, a Preparation of Mesenchymal Stromal Cells Engineered to Express IL12 and IL21, Induces Localized and Durable Antitumor Immunity in Preclinical Models of Peritoneal Solid Tumors Gonzalez-Junca, Alba; Liu, Frances D.; Nagaraja, Archana S.; Mullenix, Alyssa; Lee, Chen-Ting; Gordley, Russell M.; Frimannsson, Daniel O.; Maller, Ori; Garrison, Brian S.; Iyer, Dharini; Benabbas, Anissa; Truong, Tiffany A.; Quach, Allison; Tian, Mengxi; Martinez, Rowena; Savur, Rishi; Perry-McNamara, Alyssa; Nguyen, Denny; Almudhfar, Niran; Blanco, Carmina; Huynh, Christina; Nand, Asish; Lay, Yu-An E.; Magal, Ashita; Mangalampalli, Sravani; Lee, Philip J.; Lu, Timothy K.; Lee, Gary 分享 收藏
SENTI-101, a novel genetically modified allogeneic cell product expressing IL12 and IL21, elicits a tumor-localized, robust, and multimodal immune response in preclinical models of solid tumors Gonzalez, Alba; Liu, Frances D.; Nagaraja, Archana; Mullenix, Alyssa; Gordley, Russell M.; Frimannsson, Daniel O.; Benabbas, Anissa; Lee, Chen-Ting; Truong, Tiffany A.; Quach, Allison; Tian, Mengxi; Martinez, Rowena; Savur, Rishi; Perry-McNamara, Alyssa; Wang, Don-Hong; Maller, Ori; Iyer, Dharini; Magal, Ashita; Mangalampalli, Sravani; Huynh, Christina J.; Blanco, Carmina C.; Lin, Jack T.; Garrison, Brian S.; Lee, Philip; Lu, Timothy K.; Lee, Gary 分享 收藏
Assessing effects of pressure on tumor and normal tissue physiology using an automated self-calibrated, pressure-sensing probe for diffuse reflectance spectroscopy Palmer, Gregory M.; Zhang, Hengtao; Lee, Chen-Ting; Mikati, Husam; Herbert, Joseph A.; Krieger, Marlee; von Windheim, Jesko; Koester, Dave; Stevenson, Daniel; Rocke, Daniel J.; Esclamado, Ramon; Erkanli, Alaatin; Ramanujam, Nirmala; Dewhirst, Mark W.; Lee, Walter T. 分享 收藏
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Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements Wallace, M. Ariel Geer; Kwon, Do-Yeon; Weitzel, Douglas H.; Lee, Chen-Ting; Stephenson, Tesia N.; Chi, Jen-Tsan; Mook, Robert A., Jr.; Dewhirst, Mark W.; Hong, Jiyong; Fitzgerald, Michael C. 分享 收藏
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Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition Kwon, Do-Yeon; Lee, Hye Eun; Weitzel, Douglas H.; Park, Kyunghye; Lee, Sun Hee; Lee, Chen-Ting; Stephenson, Tesia N.; Park, Hyeri; Fitzgerald, Michael C.; Chi, Jen-Tsan; Mook, Robert A., Jr.; Dewhirst, Mark W.; Lee, You Mie; Hong, Jiyong 分享 收藏
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