Michael J. O’Neill - Publications, H-index & Citations

Michael J. O’Neill

Eli Lilly

49H指数

210论文数

7.4K被引数

收录论文 48

发表时间

Academic Drug Discovery Units in the UK: Progress and challenges

DRUG DISCOVERY TODAY

IF7.5

2025-01-01

PREAI

Hopkins, Michael M.; Mestre-Ferrandiz, Jorge; Crane, Phillipa; O'Neill, Michael

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain (Vol 11, 181, 2023)

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2024-07-15

OAAI

Frey, Bryan; Holzinger, David; Taylor, Keenan; Ehrnhoefer, Dagmar E.; Striebinger, Andreas; Biesinger, Sandra; Gasparini, Laura; O'Neill, Michael J.; Wegner, Florian; Barghorn, Stefan; Hoeglinger, Guenter U.; Heym, Roland G.

Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge TREM2 p.R47H携带者和轻度认知障碍患者的小胶质细胞活化，tau和淀粉样蛋白沉积: 流感疫苗免疫挑战的多模式/多示踪剂PET/MRI成像研究

JOURNAL OF NEUROINFLAMMATION

IF10.1

2023-11-21

OAAI

Cousins, Oliver; Schubert, Julia J.; Chandra, Avinash; Veronese, Mattia; Valkimadi, Polena; Creese, Byron; Khan, Zunera; Arathimos, Ryan; Hampshire, Adam; Rosenzweig, Ivana; Ballard, Clive; Corbett, Anne; Aasland, Dag; Velayudhan, Latha; O'Neill, Michael; Collier, David; Awais, Ramla; Sander, Kerstin; Arstad, Erik; Howes, Oliver; Turkheimer, Federico; Hodges, Angela

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain Tau种子扩增试验揭示了阿尔茨海默病脑中tau的播种与病理形式之间的关系

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2023-11-14

OAAI

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model

BRAIN

IF11.7

2020-07-23

OAAI

Harrison, Ian F.; Ismail, Ozama; Machhada, Asif; Colgan, Niall; Ohene, Yolanda; Nahavandi, Payam; Ahmed, Zeshan; Fisher, Alice; Meftah, Soraya; Murray, Tracey K.; Ottersen, Ole P.; Nagelhus, Erlend A.; O'Neill, Michael J.; Wells, Jack A.; Lythgoe, Mark F.

Transcriptional Signatures of Tau and Amyloid Neuropathology

CELL REPORTS

IF6.9

2020-02-01

OAAI

Castanho, Isabel; Murray, Tracey K.; Hannon, Eilis; Jeffries, Aaron; Walker, Emma; Laing, Emma; Baulf, Hedley; Harvey, Joshua; Bradshaw, Lauren; Randall, Andrew; Moore, Karen; O'Neill, Paul; Lunnon, Katie; Collier, David A.; Ahmed, Zeshan; O'Neill, Michael J.; Mill, Jonathan

Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia (vol 7, 4, 2019)

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2019-08-05

OAAI

Harrison, Ian F.; Whitaker, Rozalind; Bertelli, Pietro Maria; O'Callaghan, James M.; Csincsik, Lajos; Wells, Jack A.; Bocchetta, Martina; Ma, Da; Fisher, Alice; Ahmed, Zeshan; Murray, Tracey K.; O'Neill, Michael J.; Rohrer, Jonathan D.; Lythgoe, Mark F.; Lengyel, Imre

Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network Tau蛋白聚集体抑制细胞蛋白平衡网络的蛋白折叠和囊泡运输臂

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-05-01

OAAI

Yu, Anan; Fox, Susan G.; Cavallini, Annalisa; Kerridge, Caroline; O'Neill, Michael J.; Wolak, Joanna; Bose, Suchira; Morimoto, Richard I.

Study the Longitudinal in vivo and Cross-Sectional ex vivo Brain Volume Difference for Disease Progression and Treatment Effect on Mouse Model of Tauopathy Using Automated MRI Structural Parcellation

FRONTIERS IN NEUROSCIENCE

IF3.2

2019-01-24

OAAI

Ma, Da; Holmes, Holly E.; Cardoso, Manuel J.; Modat, Marc; Harrison, Ian F.; Powell, Nick M.; O'Callaghan, James M.; Ismail, Ozama; Johnson, Ross A.; O'Neill, Michael J.; Collins, Emily C.; Beg, Mirza F.; Popuri, Karteek; Lythgoe, Mark F.; Ourselin, Sebastien

Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2019-01-07

OAAI

Harrison, Ian F.; Whitaker, Rozalind; Bertelli, Pietro Maria; O'Callaghan, James M.; Csincsik, Lajos; Bocchetta, Martina; Ma, Da; Fisher, Alice; Ahmed, Zeshan; Murray, Tracey K.; O'Neill, Michael J.; Rohrer, Jonathan D.; Lythgoe, Mark F.; Lengyel, Imre

In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis

FRONTIERS IN NEUROSCIENCE

IF3.2

2017-11-06

OAAI

Colgan, Niall; Ganeshan, Balaji; Harrison, Ian F.; Ismail, Ozama; Holmes, Holly E.; Wells, Jack A.; Powell, Nick M.; O'Callaghan, James M.; O'Neill, Michael J.; Murray, Tracey K.; Ahmed, Zeshan; Collins, Emily C.; Johnson, Ross A.; Groves, Ashley; Lythgoe, Mark F.

A high-throughput model for investigating neuronal function and synaptic transmission in cultured neuronal networks

SCIENTIFIC REPORTS

IF3.9

2017-11-03

OAAI

Virdee, Jasmeet K.; Saro, Gabriella; Fouillet, Antoine; Findlay, Jeremy; Ferreira, Filipa; Eversden, Sarah; O'Neill, Michael J.; Wolak, Joanna; Ursu, Daniel

Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo

MOLECULAR THERAPY

IF12

2017-10-01

111

OAAI

McMillan, Kirsty J.; Murray, Tracey K.; Bengoa-Vergniory, Nora; Cordero-Llana, Oscar; Cooper, Jane; Buckley, Amy; Wade-Martins, Richard; Uney, James B.; O'Neill, Michael J.; Wong, Liang F.; Caldwell, Maeve A.

Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy

ALZHEIMERS RESEARCH & THERAPY

IF7.6

2017-09-20

OAAI

Blackmore, Thomas; Meftah, Soraya; Murray, Tracey Karen; Craig, Peter James; Blockeel, Anthony; Phillips, Keith; Eastwood, Brian; O'Neill, Michael J.; Marston, Hugh; Ahmed, Zeshan; Gilmour, Gary; Gastambide, Francois

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IF4.5

2017-08-11

112

OAAI

du Sert, Nathalie Percie; Alfieri, Alessio; Allan, Stuart M.; Carswell, Hilary V. O.; Deuchar, Graeme A.; Farr, Tracy D.; Flecknell, Paul; Gallagher, Lindsay; Gibson, Claire L.; Haley, Michael J.; Macleod, Malcolm R.; McColl, Barry W.; McCabe, Christopher; Morancho, Anna; Moon, Lawrence D. F.; O'Neill, Michael J.; de Puig, Isabel Perez; Planas, Anna; Ragan, C. Ian; Rosell, Anna; Roy, Lisa A.; Ryder, Kathryn O.; Simats, Alba; Sena, Emily S.; Sutherland, Brad A.; Tricklebank, Mark D.; Trueman, Rebecca C.; Whitfield, Lucy; Wong, Raymond; Macrae, I. Mhairi

Altered Synapse Stability in the Early Stages of Tauopathy

CELL REPORTS

IF6.9

2017-03-01

OAAI

Jackson, Johanna S.; Witton, Jonathan; Johnson, James D.; Ahmed, Zeshan; Ward, Mark; Randall, Andrew D.; Hutton, Michael L.; Isaac, John T.; O'Neill, Michael J.; Ashby, Michael C.

Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2016-10-18

OAAI

Mead, Emma; Kestoras, Dimitra; Gibson, Yolanda; Hamilton, Lucy; Goodson, Ross; Jones, Sophie; Eversden, Sarah; Davies, Peter; O'Neill, Michael; Hutton, Michael; Szekeres, Philip; Wolak, Joanna

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2016-05-18

OAAI

Lau, Dawn H. W.; Hogseth, Marte; Phillips, Emma C.; O'Neill, Michael J.; Pooler, Amy M.; Noble, Wendy; Hanger, Diane P.

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2016-03-31

101

OAAI

Kurbatskaya, Ksenia; Phillips, Emma C.; Croft, Cara L.; Dentoni, Giacomo; Hughes, Martina M.; Wade, Matthew A.; Al-Sarraj, Safa; Troakes, Claire; O'Neill, Michael J.; Perez-Nievas, Beatriz G.; Hanger, Diane P.; Noble, Wendy

Imaging the accumulation and suppression of tau pathology using multiparametric MRI

NEUROBIOLOGY OF AGING

IF3.5

2016-03-01

OAAI

Holmes, Holly E.; Colgan, Niall; Ismail, Ozama; Ma, Da; Powell, Nick M.; O'Callaghan, James M.; Harrison, Ian F.; Johnson, Ross A.; Murray, Tracey K.; Ahmed, Zeshan; Heggenes, Morton; Fisher, Alice; Cardoso, M. J.; Modat, Marc; Walker-Samuel, Simon; Fisher, Elizabeth M. C.; Ourselin, Sebastien; O'Neill, Michael J.; Wells, Jack A.; Collins, Emily C.; Lythgoe, Mark F.

研究方向