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PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacy Sasikumar, Pottayil G.; Sudarshan, Naremaddepalli S.; Adurthi, Srinivas; Ramachandra, Raghuveer K.; Samiulla, Dodderi S.; Lakshminarasimhan, Anirudha; Ramanathan, Anuradha; Chandrasekhar, Talapaneni; Dhudashiya, Amit A.; Talapati, Sumalatha R.; Gowda, Nagesh; Palakolanu, Sreenivasulareddy; Mani, Jiju; Srinivasrao, Bandi; Joseph, David; Kumar, Nigam; Nair, Rashmi; Atreya, Hanudatta S.; Gowda, Nagaraj; Ramachandra, Murali 分享 收藏
An orally bioavailable small molecule antagonist of TIM-3 signaling pathway shows potent anti-tumor activity Sasikumar, Pottayil G.; Naremaddepalli, Sudarshan S.; Ramachandra, Raghuveer K.; Gowda, Nagesh; Devarapalli, Srinivaskumar; Adurthi, Sreenivas; Mani, Jiju; Nair, Rashmi; Dhudashiya, Amit A.; Samiulla, Dodheri S.; Gowda, Nagaraj M.; Ramachandra, Murali 分享 收藏
A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy Sasikumar, Pottayil G.; Ramachandra, Raghuveer K.; Adurthi, Srinivas; Dhudashiya, Amit A.; Vadlamani, Sureshkumar; Vemula, Koteswararao; Vunnum, Sriharibabu; Satyam, Leena K.; Samiulla, Dodderi S.; Subbarao, Krishnaprasad; Nair, Rashmi; Shrimali, Rajeev; Gowda, Nagaraj; Ramachandra, Murali 分享 收藏
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity Holmstrom, Tim H.; Moilanen, Anu-Maarit; Ikonen, Tarja; Bjorkman, Mari L.; Linnanen, Tero; Wohlfahrt, Gerd; Karlsson, Stefan; Oksala, Riikka; Korjamo, Timo; Samajdar, Susanta; Rajagopalan, Srinivasan; Chelur, Shekar; Narayanan, Kishore; Ramachandra, Raghuveer K.; Mani, Jiju; Nair, Rashmi; Gowda, Nagaraj; Anthony, Thomas; Dhodheri, Samiulla; Mukherjee, Subhendu; Ujjinamatada, Ravi K.; Srinivas, Nanduri; Ramachandra, Murali; Kallio, Pekka J. 分享 收藏
Functional antagonism of VSIG8-mediated immune suppression by oral VISTA agents Sasikumar, Pottayil G.; Naremaddepalli, Sudarshan S.; Ramachandra, Raghuveer K.; Gowda, Nagesh; Yerramsetti, Manikyala Rao; Bandireddy, Srinivasa Rao; Adurthi, Sreenivas; Mani, Jiju; Nair, Rashmi; Dhudashia, Amit A.; Dodheri, Samiulla S.; Gowda, Nagaraj M.; Ramachandra, Murali 分享 收藏
Targeting CD47-SIRPa interaction by novel peptide-based antagonists Sasikumar, Pottayil G.; Gundala, Chennakrishnareddy; Gowda, Nagaraj M.; Naremaddepalli, Sudarshan S.; Bhumireddy, Archana; Nair, Rashmi; Balasubramanian, Wesley Roy; Lakshminarasimhan, Anirudha; Dodheri, Samiulla S.; Aithal, Kiran; Ramachandra, Raghuveer K.; Daginakatte, Girish; Ramachandra, Murali 分享 收藏
Pre-clinical efficacy in multiple syngeneic models with oral immune checkpoint antagonists targeting PD-L1 and TIM-3 Sasikumar, P.; Sudarshan, N.; Ramachandra, R.; Gowda, N.; Samiulla, D.; Bilugudi, P.; Adurthi, S.; Mani, J.; Nair, R.; Gowda, N.; Ramachandra, M. 分享 收藏
Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases Murone, Maximilien; Chessex, Anne Vaslin; Attinger, Antoine; Ramachandra, Raghuveer; Shetty, Shankar J.; Daginakatte, Girish; Sengupta, Saumitra; Marappan, Sivapriya; Dhodheri, Samiulla; Rigotti, Stefania; Bachhav, Yogeshwar; Brienza, Silvano; Traxler, Peter; Lang, Marc; Aguet, Michel; Zoete, Vincent; Michielin, Olivier; Nicholas, Courtney; Johnson, Faye M.; Ramachandra, Murali; McAllister, Andres 分享 收藏
Oral immune checkpoint antagonists targeting PD-L1/VISTA or PD-L1/Tim3 for cancer therapy Sasikumar, Pottayil; Sudarshan, N. S.; Gowda, Nagaraj; Samiulla, D. S.; Ramachandra, Raghuveer; Chandrasekhar, T.; Adurthi, Sreenivas; Mani, Jiju; Nair, Rashmi; Singh, Sharad; Dhudashia, Amit; Gowda, Nagesh; Ramachandra, Murali 分享 收藏
Potent and selective inhibition of CDK7 by novel covalent inhibitors Satyam, Leena Khare; Poddutoori, Ramulu; Mukherjee, Subhendu; Marappan, Sivapriya; Gopinath, Sreevalsam; Ramachandra, Raghuveer; Pothuganti, Manoj Kumar; Nayak, Shilpa S.; Nandish, C.; Naik, Chandranath; Ravindra, M., V; Dabbeeru, Madhu B.; Nagaraju, A.; Mahankali, B.; Antony, Thomas; Pandit, Chetan; Chelur, Shekar; Daginakatte, Girish; Sannajdar, Susanta; Ramachandra, Murali 分享 收藏
Identification of novel covalent inhibitors of K-Ras Gl2C that are efficacious in a xenograft model of NSCLC Satyam, Leena Khare; Chikkanna, Dinesh; Aswani, K. G.; Khairnar, Vinayak V.; Reddy, Sreekanth; Durgaprasad, Vakkapatla; Radhakrishna, Kowju; Panigrahi, Sunil K.; Ramanathan, Anuradha; Mahasweta, Kumari; Lakshminarasimhan, Anirudha; Narasimha, R. K.; Vinutha, R.; Gopinath, Sreevalsam; Kumar, Suryakant; Shah, Mubarak H.; Ramachandra, Raghuveer; Kiran, A. B.; Pandit, Chetan; Ramachandra, Murali 分享 收藏
Novel NAMPT inhibitors for the treatment of Pancreatic cancer Chikanna, Dinesh; Lakshminarasimhan, Anirudha; Khairnar, Vinayak; Panigrahi, Sunil; Ramanathan, Anuradha; Rao, Narasimha; Narayanan, Kishore; Gopinath, Sreevalsam; Ramachandra, Raghuveer; Chelur, Shekar; Pandit, Chetan; Ramachandra, Murali 分享 收藏
ODM-203, a novel, selective and balanced FGFR and VEGFR inhibitor with strong activity on primary and metastatic tumor growth in FGFR-dependent and angiogenic cancer models Holmstrom, Tim; Moilanen, Anu; Bjorkman, Mari; Linnanen, Tero; Wohlfahrt, Gerd; Karlsson, Stefan; Oksala, Riikka; Korjamo, Timo; Samajdar, Susanta; Rajagopalan, Srinivasan; Chelur, Shekar; Narayan, Kishore; Ramachandra, Raghuveer; Anthony, Thomas; Samiulla, D. S.; Ramachandra, Murali; Kallio, Pekka 分享 收藏
Discovery of dihydro-isoxazole derivatives as novel inhibitors of NAMPT for the treatment of multiple myeloma Chikkanna, Dinesh; Lakshminarasimhan, Anirudha; Khairnar, Vinayak; Panigrahi, Sunil; Ramanathan, Anuradha; Rani, Sumalatha; Rao, Narasimha; Karthikeyan, S.; Narayanan, Kishore; Gopinath, Sreevalsam; Ramachandra, Raghuveer; Charamanna, K. B.; Chelur, Shekar; Pandit, Chetan; Ramachandra, Murali 分享 收藏
ODM-203, a novel, selective and balanced FGFR and VEGFR inhibitor with strong anti-tumor activity in FGFR- and VEGFR-dependent cancer models Holmstrom, T.; Moilanen, A.; Linnanen, T.; Wohlfahrt, G.; Karlsson, S.; Oksala, R.; Korjamo, T.; Bjorkman, M.; Samajadar, S.; Rajagopalan, S.; Chelur, S.; Narayan, K.; Ramachandra, R.; Anthony, T.; Ds, S.; Ramachandra, M.; Kallio, P. 分享 收藏
Novel inhibitors of nicotinamide phosphoribosyl transferase and their evaluation in combination with bortezomib. Chikkanna, Dinesh; Lakshminarasimhan, Anirudha; Khairnar, Vinayak; Panigrahi, Sunil; Ramanathan, Anuradha; Satyanandan, Aparna; Rao, Narasimha; Karthikeyan, S.; Narayanan, Kishore; Gopinath, Sreevalsam; Ramachandra, Raghuveer; Subramanya, Hosahalli; Pandit, Chetan; Ramachandra, Murali 分享 收藏
Antitumor efficacy of AUR-012, a peptide antagonist of the PD1 immune checkpoint pathway, correlates well with the modulation of specific T-cell populations. Ramachandra, Murali; Sasikumar, Pottayil G.; Shrimali, Rajeev K.; Adurthi, Sreenivas; Ramachandra, Raghuveer; Satyam, Leena K.; Dhudashiya, Amit A.; Samiulla, Dodheri S.; Sunilkumar, K. B. 分享 收藏
Anti-tumor Efficacy with a Novel Peptide Inhibitor of the PD-1 Immune Check Point Pathway Ramachandra, M.; Sasikumar, P. G.; Satyam, L. K.; Shrimali, R. K.; Subbarao, K.; Ramachandra, R.; Vadlamani, S.; Reddy, A.; Sreenivas, A.; Samiulla, D. S. 分享 收藏
Demonstration of anti-tumor efficacy in multiple preclinical cancer models using a novel peptide inhibitor (Aurigene-012) of the PD1 signaling pathway Sasikumar, Pottayil G.; Satyam, Leena K.; Shrimali, Rajeev K.; Subbarao, Krishnaprasad; Ramachandra, Raghuveer; Vadlamani, Sureshkumar; Reddy, Amarnadh; Kumar, Aswani; Srinivas, Adurthi; Reddy, Subba; Gopinath, Sreevalsam; Samiulla, Dodderi S.; Ramachandra, Murali 分享 收藏
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