未登录

C

Chengde Wu

glaxosmithkline usa

H指数:14

被引数:698

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-05-134

OAAI

Discovery of 3-Quinazolin-4(3H)-on-3-yl-2,N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-06-106

OAAI

Discovery and Evaluation of Pyrazolo[3,4-d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2019-12-1116

OAAI

Discovery and evaluation of WX047, a potent and oral active phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitor

CANCER RESEARCH

IF16.6

2018-07-010

PRE

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

发现一流的肠道限制性RET激酶抑制剂作为治疗IBS的临床候选药物

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-05-2431

OAAI

Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-02-2714

OAAI

Design, Synthesis, and Structure-Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-09-0129

PREAI

Genetic algorithm-optimized QSPR models for bioavailability, protein binding, and urinary excretion

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2006-10-0660

PRE

Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2004-03-16118

PREAI

TBC3711, an ETA receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets

PEDIATRIC RESEARCH

IF3.1

2001-09-0137

OAAI

Acyl substitution at the ortho position of anilides enhances oral bioavailability of thiophene sulfonamides:: TBC3214, an ETA selective endothelin antagonist

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2001-03-1329

PREAI

Endothelin antagonists:: Substituted mesitylcarboxamides with high potency and selectivity for ETA receptors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

1999-10-0529

PREAI

The discovery and structure-activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ETB receptor

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

1998-12-0132

PREAI

Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

1997-05-23133

PREAI

Structure-activity relationships of N-2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as selective endothelin receptor-A antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

1997-05-2332

PREAI