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收藏DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity
Sustmann, Claudio; Dickopf, Steffen; Regula, Joerg T.; Kettenberger, Hubert; Molhoj, Michael; Gassner, Christian; Weininger, Diana; Fenn, Sebastian; Manigold, Tobias; Kling, Lothar; Kuenkele, Klaus-Peter; Schwaiger, Manfred; Bossenmaier, Birgit; Griese, Julia J.; Hopfner, Karl-Peter; Graff-Meyer, Alexandra; Stahlberg, Henning; Ringler, Philippe; Lauer, Matthias E.; Brinkmann, Ulrich; Schaefer, Wolfgang; Klein, Christian
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收藏Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies
Klein, Christian; Sustmann, Claudio; Thomas, Markus; Stubenrauch, Kay; Croasdale, Rebecca; Schanzer, Juergen; Brinkmann, Ulrich; Kettenberger, Hubert; Regula, Joerg T.; Schaefer, Wolfgang
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收藏Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficiency
Lorenzon, Erica; Kienaat, Yvonne; Raemsch, Romi; Scheuer, Werner; Herting, Frank; Bernicke, Dirk; Schaefer, Wolfgang; Regula, Joerg; Stubenrauch, Kay; Yu, Sidney; The, Huynh Hung; Martarello, Laurent; Klein, Christian; Thomas, Markus
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收藏Dual inhibition of Ang-2 and VEGF via a novel human bispecific bivalent IgG1 CrossMAb shows potent anti-angiogenic, antitumoral, and antimetastatic efficacy and leads to a reduced side effect profile compared to single therapies
Thomas, Markus; Kienast, Yvonne; Scheuer, Werner; Lorenzon, Erica; Herting, Frank; Odin, Marielle; Schaefer, Wolfgang; Regula, Joerg Thomas; Stubenrauch, Kay-Gunnar; Klein, Christian
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收藏Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
Schaefer, Wolfgang; Regula, Joerg T.; Baehner, Monika; Schanzer, Juergen; Croasdale, Rebecca; Duerr, Harald; Gassner, Christian; Georges, Guy; Kettenberger, Hubert; Imhof-Jung, Sabine; Schwaiger, Manfred; Stubenrauch, Kay G.; Sustmann, Claudio; Thomas, Markus; Scheuer, Werner; Klein, Christian
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