Hasige A. Sathish - Publications, H-index & Citations

Hasige A. Sathish

AstraZeneca

21H指数

43论文数

1.6K被引数

收录论文 17

发表时间

Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics 用于蛋白质疗法高浓度制剂开发的抗体聚集和粘度的机器学习预测

MABS

IF7.3

2022-01-25

OAAI

Lai, Pin-Kuang; Gallegos, Austin; Mody, Neil; Sathish, Hasige A.; Trout, Bernhardt L.

Understanding the Role of Preferential Exclusion of Sugars and Polyols from Native State IgG1 Monoclonal Antibodies and its Effect on Aggregation and Reversible Self-Association

PHARMACEUTICAL RESEARCH

IF4.3

2019-05-24

PREAI

Sudrik, Chaitanya M.; Cloutier, Theresa; Mody, Neil; Sathish, Hasige A.; Trout, Bernhardt L.

Electrostatically Mediated Protein-Protein Interactions for Monoclonal Antibodies: A Combined Experimental and Coarse-Grained Molecular Modeling Approach

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2019-01-01

PREAI

Ferreira, Glenn M.; Calero-Rubio, Cesar; Sathish, Hasige A.; Remmele, Richard L., Jr.; Roberts, Christopher J.

Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity

MABS

IF7.3

2016-08-25

OAAI

Arora, Jayant; Hu, Yue; Esfandiary, Reza; Sathish, Hasige A.; Bishop, Steven M.; Joshi, Sangeeta B.; Middaugh, C. Russell; Volkin, David B.; Weis, David D.

Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

MABS

IF7.3

2016-04-06

OAAI

Geoghegan, James C.; Fleming, Ryan; Damschroder, Melissa; Bishop, Steven M.; Sathish, Hasige A.; Esfandiary, Reza

Computational tool for the early screening of monoclonal antibodies for their viscosities

MABS

IF7.3

2015-09-23

OAAI

Agrawal, Neeraj J.; Helk, Bernhard; Kumar, Sandeep; Mody, Neil; Sathish, Hasige A.; Samra, Hardeep S.; Buck, Patrick M.; Li, Li; Trout, Bernhardt L.

Mechanism of Reversible Self-Association of a Monoclonal Antibody: Role of Electrostatic and Hydrophobic Interactions

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2015-02-01

OAAI

Esfandiary, Reza; Parupudi, Arun; Casas-Finet, Jose; Gadre, Dhanesh; Sathish, Hasige

A Systematic Multitechnique Approach for Detection and Characterization of Reversible Self-Association during Formulation Development of Therapeutic Antibodies

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2013-09-01

OAAI

Esfandiary, Reza; Hayes, David B.; Parupudi, Arun; Casas-Finet, Jose; Bai, Shufeng; Samra, Hardeep S.; Shah, Ambarish U.; Sathish, Hasige A.

Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2013-07-01

103

PREAI

Manikwar, Prakash; Majumdar, Ranajoy; Hickey, John M.; Thakkar, Santosh V.; Samra, Hardeep S.; Sathish, Hasige A.; Bishop, Steven M.; Middaugh, C. Russell; Weis, David D.; Volkin, David B.

A systematic multitechnique approach for detection and characterization of reversible self-association during formulation development of therapeutic antibodies

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2013-01-01

PREAI

Esfandiary, Reza; Hayes, David B.; Parupudi, Arun; Casas-Finet, Jose; Bai, Shufeng; Samra, Hardeep S.; Shah, Ambarish U.; Sathish, Hasige A.

Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2012-12-01

PREAI

Thakkar, Santosh V.; Kim, Jae Hyun; Samra, Hardeep S.; Sathish, Hasige A.; Bishop, Steven M.; Joshi, Sangeeta B.; Volkin, David B.; Middaugh, C. Russell

Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2012-09-01

OAAI

Thakkar, Santosh V.; Joshi, Sangeeta B.; Jones, Matthew E.; Sathish, Hasige A.; Bishop, Steven M.; Volkin, David B.; Middaugh, C. Russell

Buffer-Dependent Fragmentation of a Humanized Full-Length Monoclonal Antibody

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2010-07-01

OAAI

Salinas, Branden A.; Sathish, Hasige A.; Shah, Ambarish U.; Carpenter, John F.; Randolph, Theodore W.