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C

Christian Goess

abbvie bioresearch center
H指数:11
被引数:359

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荣誉奖项

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Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators

作为口服有效的桥连哌嗪的smTNF调节剂的发现

Journal of Medicinal Chemistry
IF6.8
2025-07-090
PRE
Zhiguo Bian; Robert G. Schmidt; Noel S. Wilson; David B. Duignan; Eric Breinlinger; Amanda W. Dombrowski; Paul Erdman; C. Michael Foley; Michael Friedman; Gregory A. Gfesser; Christian A. Goess; Arthur Gomtsyan; Russell A. Judge; Ryota Kikuchi; Yevgeniya Koshman; Xiaoqin Liu; Kenton L. Longenecker; Andrea McClure; Kevin Sippy; Jill M. Wetter; Robert Stoffel; Anil Vasudevan
Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammation
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2025-03-010
PRE
Goedken, Eric R.; Su, Zhi; Lipovsky, Alex; Kannan, Arun; Chu, Katharine L.; Ciura, Samantha; Foley, Sage E.; Frank, Kristine E.; Goess, Christian A.; Gopalakrishnan, Sujatha; Greszler, Stephen N.; Khan, Hasan A.; Leys, Laura J.; King, Jacob J.; Mathieu, Suzanne L.; Panchal, Sanjay C.; Paulsboe, Stephanie; Perham, Matt; Ramos, Ashley L.; Slivka, Peter F.; Srikumaran, Myron; Webster, Matthew P.; Wambeke, Emma L.; Zhu, Haizhong; Scott, Victoria E.; Mcgaraughty, Steve; Honore, Prisca
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-03-205
PRE
McPherson, Michael J.; Hobson, Adrian D.; Hernandez, Axel, Jr.; Marvin, Christopher C.; Waegell, Wendy; Goess, Christian; Oh, Jason Z.; Shi, Dan; Hayes, Martin E.; Wang, Lu; Schmidt, Diana; Wang, Zhi; Pitney, Victoria; McCarthy, Kimberley; Jia, Ying; Wang, Ce; Kang, Bit Na; Bryant, Shaughn; Mathieu, Suzanne; Ruzek, Melanie; Parmentier, Julie; D'Cunha, Ronilda R.; Pang, Yinuo; Phillips, Lucy; Brown, Nathan J.; Xu, Jianwen; Graff, Candace; Tian, Yu; Longenecker, Kenton L.; Qiu, Wei; Zhu, Haizhong; Liu, Wei; Zheng, Pingping; Bi, Yingtao; Stoffel, Robert
Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-09-0111
PRE
Hobson, Adrian D.; Xu, Jianwen; Welch, Dennie S.; Marvin, Christopher C.; Mcpherson, Michael J.; Gates, Bradley; Liao, Xiaoli; Hollmann, Markus; Gattner, Michael J.; Dzeyk, Kristina; Sarvaiya, Hetal; Shenoy, Vikram M.; Fettis, Margaret M.; Bischoff, Agnieszka K.; Wang, Lu; Santora, Ling C.; Wang, Lu; Fitzgibbons, Julia; Salomon, Paulin; Hernandez Jr, Axel; Jia, Ying; Goess, Christian A.; Mathieu, Suzanne L.; Bryant, Shaughn H.; Larsen, Mary E.; Cui, Baoliang; Tian, Yu
Optimization of Drug-Linker to Enable Long-term Storage of Antibody-Drug Conjugate for Subcutaneous Dosing
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-06-2811
PRE
Hobson, Adrian D.; Xu, Jianwen; Marvin, Christopher C.; McPherson, Michael J.; Hollmann, Markus; Gattner, Michael; Dzeyk, Kristina; Fettis, Margaret M.; Bischoff, Agnieszka K.; Wang, Lu; Fitzgibbons, Julia; Wang, Lu; Salomon, Paulin; Hernandez Jr, Axel; Jia, Ying; Sarvaiya, Hetal; Goess, Christian A.; Mathieu, Suzanne L.; Santora, Ling C.
Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads (vol 65, pg 4500, 2022)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-04-140
PRE
Hobson, Adrian D.; McPherson, Michael J.; Waegell, Wendy; Goess, Christian A.; Stoffel, Robert H.; Li, Xiang; Zhou, Jian; Wang, Zhongyuan; Yu, Yajie; Hernandez, Axel, Jr.; Bryant, Shaughn H.; Mathieu, Suzanne L.; Bischoff, Agnieszka K.; Fitzgibbons, Julia; Pawlikowska, Martyna; Puthenveetil, Sujiet; Santora, Ling C.; Wang, Lu; Marvin, Christopher C.; Hayes, Martin E.; Shrestha, Anurupa; Sarris, Kathy A.; Li, Biqin
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate (vol 65, pg 15893, 2022)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-04-070
OA
Hobson, Adrian D.; McPherson, Michael J.; Hayes, Martin E.; Goess, Christian; Li, Xiang; Zhou, Jian; Wang, Zhongyuan; Yu, Yajie; Yang, Jindong; Sun, Liang; Zhang, Qiang; Qu, Pei; Yang, Shi; Hernandez Jr, Axel; Bryant, Shaughn H.; Mathieu, Suzanne L.; Bischoff, Agnieszka K.; Fitzgibbons, Julia; Santora, Ling C.; Wang, Lu; Fettis, Margaret M.; Li, Xiaofeng; Marvin, Christopher C.; Wang, Zhi; Patel, Meena, V; Schmidt, Diana L.; Li, Tongmei; Randolph, John T.; Henry, Rodger F.; Graff, Candace; Tian, Yu; Aguirre, Ana L.; Shrestha, Anurupa
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-11-1723
PRE
Hobson, Adrian D.; McPherson, Michael J.; Hayes, Martin E.; Goess, Christian; Li, Xiang; Zhou, Jian; Wang, Zhongyuan; Yu, Yajie; Yang, Jindong; Sun, Liang; Zhang, Qiang; Qu, Pei; Yang, Shi; Hernandez, Axel; Bryant, Shaughn H.; Mathieu, Suzanne L.; Bischoff, Agnieszka K.; Fitzgibbons, Julia; Santora, Ling C.; Wang, Lu; Fettis, Margaret M.; Li, Xiaofeng; Marvin, Christopher C.; Wang, Zhi; V. Patel, Meena; Schmidt, Diana L.; Li, Tongmei; Randolph, John T.; Henry, Rodger F.; Graff, Candace; Tian, Yu; Aguirre, Ana L.; Shrestha, Anurupa
Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-02-0828
PRE
Hobson, Adrian D.; McPherson, Michael J.; Waegell, Wendy; Goess, Christian A.; Stoffel, Robert H.; Li, Xiang; Zhou, Jian; Wang, Zhongyuan; Yu, Yajie; Hernandez, Axel, Jr.; Bryant, Shaughn H.; Mathieu, Suzanne L.; Bischoff, Agnieszka K.; Fitzgibbons, Julia; Pawlikowska, Martyna; Puthenveetil, Sujiet; Santora, Ling C.; Wang, Lu; Marvin, Christopher C.; Hayes, Martin E.; Shrestha, Anurupa; Sarris, Kathy A.; Li, Biqin
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-12-3021
PRE
Dietrich, Justin D.; Longenecker, Kenton L.; Wilson, Noel S.; Goess, Christian; Panchal, Sanjay C.; Swann, Steven L.; Petros, Andrew M.; Hobson, Adrian D.; Ihle, David; Song, Danying; Richardson, Paul; Comess, Kenneth M.; Cox, Philip B.; Dombrowski, Amanda; Sarris, Kathy; Donnelly-Roberts, Diana L.; Duignan, David B.; Gomtsyan, Arthur; Jung, Paul; Krueger, A. Chris; Mathieu, Suzanne; McClure, Andrea; Stoll, Vincent S.; Wetter, Jill; Mankovich, John A.; Hajduk, Philip J.; Vasudevan, Anil; Stoffel, Robert H.; Sun, Chaohong
Inhibition of Interleukin-23-Mediated Inflammation with a Novel Small Molecule Inverse Agonist of RORγt
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2019-10-0112
OAAI
Gauld, Stephen B.; Jacquet, Sebastien; Gauvin, Donna; Wallace, Craig; Wang, Yibing; McCarthy, Richard; Goess, Christian; Leys, Laura; Huang, Susan; Su, Zhi; Edelmayer, Rebecca; Wetter, Joseph; Salte, Katherine; McGaraughty, Steven P.; Argiriadi, Maria A.; Honore, Prisca; Luccarini, Jean-Michel; Bressac, Didier; Desino, Kelly; Breinlinger, Eric; Cusack, Kevin; Potin, Dominique; Kort, Michael E.; Masson, Philippe J.

研究方向

暂未获取到该数据
S
Suzanne Mathieu
H 指数:11论文数:31被引数:372
A
Adrian D. Hobson
H 指数:15论文数:68被引数:783
S
Shaughn H. Bryant
H 指数:10论文数:29被引数:690
M
Michael J. McPherson
H 指数:52论文数:291被引数:1.0万
L
Lu Wang
H 指数:14论文数:56被引数:549
J
Julia Fitzgibbons
H 指数:6论文数:14被引数:155
L
Ling C. Santora
H 指数:10论文数:20被引数:841
A
Agnieszka K. Bischoff
H 指数:8论文数:21被引数:236
C
Christopher C. Marvin
H 指数:14论文数:50被引数:659
A
Axel Hernandez
H 指数:8论文数:23被引数:199