Niels Asger Jakobsen - Publications, H-index & Citations

Niels Asger Jakobsen

mrc weatherall institute of molecular medicine

12H指数

51论文数

494被引数

收录论文 12

发表时间

Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis 逆转录转座元件去抑制区分DNMT3A突变型和TET2突变型克隆性造血

GeroScience

IF5.4

2026-09-16

OAAI

Maroof Hasan; Sylvia Durandeau; I. Richard Thompson; Hanae Roussotte; Yi-Ting Tsai; Nogayhan Seymen; Sila Gerlevik; Nicholas Bianchini; Khadijeh Alishah; Merilyn M. Albuquerque; Jen Lewis; Laarni Bonganay; Niels Asger Jakobsen; Bernd Zeisig; Sheeba Irshad; Paresh Vyas; Eric C. W. So; Alfredo Iacoangeli; Xuesen Zheng; Sarah Mackie; Kai Yi Mok; Viktoria Uksaite; Louis-Francois Handfield; Giorgio Napolitani; James Carmichael; Ghulam J. Mufti; Anita K. Gandhi; Rajasekhar N. V. S. Suragani; Lynn Quek; Mohammad M. Karimi

Human haematopoietic stem cells remember inflammatory stress 人类造血干细胞能够记忆炎症应激

Nature

IF48.5

2026-05-27

OAAI

Andy G. X. Zeng; Murtaza S. Nagree; Niels Asger Jakobsen; Sayyam Shah; Angelica Varesi; Jasmine Ryu Won Kang; Alex Murison; Jin-Gyu Cheong; Sven Turkalj; Xuan Zhang; Felix A. Radtke; Tsega-Ab Abera; Isabel N. X. Lim; Liqing Jin; Joana Araújo; Alicia G. Aguilar-Navarro; Darrien Parris; Jessica McLeod; Hyerin Kim; Ho Seok Lee; Lin Zhang; Mason Boulanger; Elyssa Bader; Elias Gbeha; Christopher N. Parkhurst; Elvin Wagenblast; Eugenia Flores-Figueroa; Bo Wang; Gregory W. Schwartz; Leonard D. Shultz; Anna S. Nam; H. Leighton Grimes; Steven Z. Josefowicz; Philip Awadalla; Paresh Vyas; John E. Dick; Stephanie Z. Xie

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy 早期造血细胞群内的快速克隆选择预示ivosidenib联合治疗的结局

Blood

IF23.1

2025-11-07

PREAI

Sven Turkalj; Felix A. Radtke; Bilyana Stoilova; Rabea Mecklenbrauck; Angus J. Groom; Niels Asger Jakobsen; Curtis A. Lachowiez; Marlen Metzner; Batchimeg Usukhbayar; Mirian Angulo Salazar; Zhihong Zeng; Sanam Loghavi; Jennifer Marvin-Peek; Verena Körber; Farhad Ravandi; Ghayas Issa; Tapan Kadia; Vasiliki Symeonidou; Anne P. de Groot; Hagop Kantarjian; Koichi Takahashi; Marina Konopleva; Courtney D. DiNardo; Paresh Vyas

Detecting and quantifying clonal selection in somatic stem cells 检测和量化体干细胞中的克隆选择

Nature Genetics

IF0

2025-07-03

OAAI

Verena Körber; Niels Asger Jakobsen; Naser Ansari-Pour; Rachel Moore; Nina Claudino; Marlen Metzner; Eva Thielecke; Franziska Esau; Batchimeg Usukhbayar; Mirian Angulo Salazar; Simon Newman; Benjamin J. L. Kendrick; Adrian H. Taylor; Rasheed Afinowi-Luitz; Roger Gundle; Bridget Watkins; Kim Wheway; Debra Beazley; Stephanie G. Dakin; Antony Palmer; Andrew J. Carr; Paresh Vyas; Thomas Höfer

Clonal tracing with somatic epimutations reveals dynamics of blood ageing 利用体细胞表观突变进行克隆追踪揭示了血液衰老的动态过程

NATURE

IF48.5

2025-05-21

OAAI

Scherer, Michael; Singh, Indranil; Braun, Martina Maria; Szu-Tu, Chelsea; Sanchez Sanchez, Pedro; Lindenhofer, Dominik; Jakobsen, Niels Asger; Korber, Verena; Kardorff, Michael; Nitsch, Lena; Kautz, Pauline; Ruhle, Julia; Bianchi, Agostina; Cozzuto, Luca; Fromel, Robert; Beneyto-Calabuig, Sergi; Lareau, Caleb; Satpathy, Ansuman T.; Beekman, Renee; Steinmetz, Lars M.; Raffel, Simon; Ludwig, Leif S.; Vyas, Paresh; Velten, Lars

Hematopoietic stem cell heterogeneity and age-associated platelet bias are evolutionarily conserved

SCIENCE IMMUNOLOGY

IF16.3

2024-08-23

PREAI

Aksoez, Merve; Gafencu, Grigore-Aristide; Stoilova, Bilyana; Buono, Mario; Zhang, Ying; Turkalj, Sven; Meng, Yiran; Jakobsen, Niels Asger; Metzner, Marlen; Clark, Sally-Ann; Beveridge, Ryan; Thongjuea, Supat; Vyas, Paresh; Nerlov, Claus

Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging 突变干细胞在人类克隆造血中的选择性优势与对炎症和衰老的反应减弱有关

CELL STEM CELL

IF20.4

2024-08-01

OAAI

Jakobsen, Niels Asger; Turkalj, Sven; Zeng, Andy G. X.; Stoilova, Bilyana; Metzner, Marlen; Rahmig, Susann; Nagree, Murtaza S.; Shah, Sayyam; Moore, Rachel; Usukhbayar, Batchimeg; Salazar, Mirian Angulo; Gafencu, Grigore-Aristide; Kennedy, Alison; Newman, Simon; Kendrick, Benjamin J. L.; Taylor, Adrian H.; Afinowi-Luitz, Rasheed; Gundle, Roger; Watkins, Bridget; Wheway, Kim; Beazley, Debra; Murison, Alex; Aguilar-Navarro, Alicia G.; Flores-Figueroa, Eugenia; Dakin, Stephanie G.; Carr, Andrew J.; Nerlov, Claus; Dick, John E.; Xie, Stephanie Z.; Vyas, Paresh

GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells

CELL STEM CELL

IF20.4

2023-05-01

OAAI

Turkalj, Sven; Jakobsen, Niels Asger; Groom, Angus; Metzner, Marlen; Riva, Simone G.; Gur, E. Ravza; Usukhbayar, Batchimeg; Salazar, Mirian Angulo; Hentges, Lance D.; Mickute, Gerda; Clark, Kevin; Sopp, Paul; Davies, James O. J.; Hughes, Jim R.; Vyas, Paresh

A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Myeloid Malignancies

BLOOD CANCER DISCOVERY

IF11.5

2023-04-26

OAAI

Lachowiez, Curtis A.; Loghavi, Sanam; Zeng, Zhihong; Tanaka, Tomoyuki; Kim, Yi June; Uryu, Hidetaka; Turkalj, Sven; Jakobsen, Niels Asger; Luskin, Marlise R.; Duose, Dzifa Y.; Tidwell, Rebecca S. S.; Short, Nicholas J.; Borthakur, Gautam; Kadia, Tapan M.; Masarova, Lucia; Tippett, George D.; Bose, Prithviraj; Jabbour, Elias J.; Ravandi, Farhad; Daver, Naval G.; Garcia-Manero, Guillermo; Kantarjian, Hagop; Garcia, Jacqueline S.; Vyas, Paresh; Takahashi, Koichi; Konopleva, Marina; DiNardo, Courtney D.

Mutation agnostic diagnosis of clonal hematopoiesis of indeterminate potential (CHIP) using fluctuating methylation clocks

CANCER RESEARCH

IF16.6

2022-05-15

PREAI

Schenck, Ryan O.; Jakobsen, Niels Asger; Turati, Virginia; Shibata, Darryl; Vyas, Paresh; Leedham, Simon; Anderson, Alexander R. A.

From genomics to targeted treatment in haematological malingnancies: a focus on acute myeloid leukaemia 从基因组学到血液病的靶向治疗: 关注急性髓性白血病

CLINICAL MEDICINE

IF3.9

2018-04-01

OAAI

Jakobsen, Niels Asger; Vyas, Paresh

Purine nucleotide metabolism regulates expression of the human immune ligand MICA

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-03-01

OAAI

McCarthy, Michael T.; Moncayo, Gerard; Hiron, Thomas K.; Jakobsen, Niels A.; Valli, Alessandro; Soga, Tomoyoshi; Adam, Julie; O'Callaghan, Christopher A.

研究方向