Gary R. Mirams - Publications, H-index & Citations

Gary R. Mirams

university of nottingham

45H指数

220论文数

5.5K被引数

收录论文 63

发表时间

Continuation methods as a tool for parameter inference in models of biological oscillations: a case study in electrophysiology modeling 参数推断中的延续方法：生物振荡模型电生理建模的案例研究

physica d: nonlinear phenomena

IF0

2026-04-02

OAAI

Matt J. Owen; Gary R. Mirams

Think before you fit: parameter identifiability, sensitivity and uncertaintyin systems biology models 思考后再拟合：系统生物学模型中的参数可辨识性、敏感性和不确定性

Current Opinion in Systems Biology

IF2.2

2025-11-04

OAAI

Simon P. Preston; Richard D. Wilkinson; Richard H. Clayton; Mike J. Chappell; Gary R. Mirams

Resolving Artifacts in Voltage-Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings 通过计算建模解决电压钳实验中的伪影：在快速钠电流记录中的应用

Advanced Science

IF14.1

2025-06-06

OAAI

Chon Lok Lei; Alexander P. Clark; Michael Clerx; Siyu Wei; Meye Bloothooft; Teun P. de Boer; David J. Christini; Trine Krogh-Madsen; Gary R. Mirams

Parameter inference for stochastic reaction models of ion channel gating from whole-cell voltage-clamp data

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

IF3.7

2025-03-13

OAAI

Del Core, Luca; Mirams, Gary R.

Optimizing experimental designs for model selection of ion channel drug-binding mechanisms

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

IF3.7

2025-03-13

OAAI

Patten-Elliott, Frankie; Lei, Chon Lok; Preston, Simon P.; Wilkinson, Richard D.; Mirams, Gary R.

Evaluating the predictive accuracy of ion-channel models using data from multiple experimental designs

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

IF3.7

2025-03-13

OAAI

Shuttleworth, Joseph G.; Lei, Chon Lok; Windley, Monique J.; Hill, Adam P.; Preston, Simon P.; Mirams, Gary R.

Ten simple rules for training scientists to make better software

plos biology

IF3.6

2024-09-12

OAAI

Gallagher, Kit; Creswell, Richard; Lambert, Ben; Robinson, Martin; Lei, Chon Lok; Mirams, Gary R.; Gavaghan, David J.

Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies

ELIFE

IF0

2024-04-10

OAAI

Grandits, Thomas; Augustin, Christoph M.; Haase, Gundolf; Jost, Norbert; Mirams, Gary R.; Niederer, Steven A.; Plank, Gernot; Varro, Andras; Virag, Laszlo; Jung, Alexander

Understanding the impact of numerical solvers on inference for differential equation models

JOURNAL OF THE ROYAL SOCIETY INTERFACE

IF3.5

2024-03-06

OAAI

Creswell, Richard; Shepherd, Katherine M.; Lambert, Ben; Mirams, Gary R.; Lei, Chon Lok; Tavener, Simon; Robinson, Martin; Gavaghan, David J.

Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes

CELL STEM CELL

IF20.4

2024-03-01

OAAI

Raniga, Kavita; Nasir, Aishah; Vo, Nguyen T. N.; Vaidyanathan, Ravi; Dickerson, Sarah; Hilcove, Simon; Mosqueira, Diogo; Mirams, Gary R.; Clements, Peter; Hicks, Ryan; Pointon, Amy; Stebbeds, Will; Francis, Jo; Denning, Chris

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2023-11-08

OAAI

Lei, Chon Lok; Whittaker, Dominic G.; Mirams, Gary R.

Model-driven optimal experimental design for calibrating cardiac electrophysiology models

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

IF4.8

2023-10-01

OAAI

Lei, Chon Lok; Clerx, Michael; Gavaghan, David J.; Mirams, Gary R.

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

EUROPACE

IF7.4

2023-08-08

OAAI

Clark, Alexander P.; Clerx, Michael; Wei, Siyu; Lei, Chon Lok; de Boer, Teun P.; Mirams, Gary R.; Christini, David J.; Krogh-Madsen, Trine

Nuanced Interactions between AKAP79 and STIM1 with Orai1 Ca2+ Channels at Endoplasmic Reticulum-Plasma Membrane Junctions Sustain NFAT Activation AKAP79和STIM1与内质网-质膜交界处的Orai1 Ca2通道之间的细微相互作用维持NFAT激活

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-02-24

OAAI

Lin, Yu-Ping; Scappini, Erica; Landaverde, Carlos; Parekh-Glitsch, Frederick; Tucker, Charles J.; Mirams, Gary R.; Parekh, Anant B.

Ion channel model reduction using manifold boundaries

JOURNAL OF THE ROYAL SOCIETY INTERFACE

IF3.5

2022-08-10

OAAI

Whittaker, Dominic G.; Wang, Jiahui; Shuttleworth, Joseph G.; Venkateshappa, Ravichandra; Kemp, Jacob M.; Claydon, Thomas W.; Mirams, Gary R.

A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models

FRONTIERS IN PHYSIOLOGY

IF3.4

2022-04-26

OAAI

Barral, Yann-Stanislas H. M.; Shuttleworth, Joseph G.; Clerx, Michael; Whittaker, Dominic G.; Wang, Ken; Polonchuk, Liudmila; Gavaghan, David J.; Mirams, Gary R.

Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243

JOURNAL OF GENERAL PHYSIOLOGY

IF2.9

2021-08-16

OAAI

Kemp, Jacob M.; Whittaker, Dominic G.; Venkateshappa, Ravichandra; Pang, ZhaoKai; Johal, Raj; Sergeev, Valentine; Tibbits, Glen F.; Mirams, Gary R.; Claydon, Thomas W.

Neural Network Differential Equations For Ion Channel Modelling

FRONTIERS IN PHYSIOLOGY

IF3.4

2021-08-04

OAAI

Lei, Chon Lok; Mirams, Gary R.

Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia

FRONTIERS IN PHYSIOLOGY

IF3.4

2021-05-26

OAAI

Clerx, Michael; Mirams, Gary R.; Rogers, Albert J.; Narayan, Sanjiv M.; Giles, Wayne R.

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

CELL REPORTS MEDICINE

IF10.6

2020-08-01

OAAI

Davies, Mark R.; Martinec, Michael; Walls, Robert; Schwarz, Roman; Mirams, Gary R.; Wang, Ken; Steiner, Guido; Surinach, Andy; Flores, Carlos; Lave, Thierry; Singer, Thomas; Polonchuk, Liudmila

研究方向