Brian Lam - Publications, H-index & Citations

Brian Lam

university of toronto

49H指数

194论文数

7.5K被引数

收录论文 93

发表时间

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation 微生物色氨酸代谢物吲哚作用于胃肠道，通过增强GLP-1分泌和l细胞分化来改善糖尿病小鼠模型中的葡萄糖稳态

Diabetologia

IF10.2

2026-03-04

OAAI

Phyllis Phuah; Mariana Norton; Sijing Cheng; Anna G. Roberts; Daniela Pirri; Leah Meyer; Pei-En Chung; Cecilia Dunsterville; Rafal Karwowski; Brian Y. H. Lam; Emile Otsubo; Sofia Aleksashina; Fiona M. Gribble; Frank Reimann; Aylin C. Hanyaloglu; Giles S. H. Yeo; Gavin A. Bewick; Ben Jones; Bryn Owen; Kevin G. Murphy

Cardiovascular-Kidney Effects of Dapagliflozin in Patients at Cardiovascular Risk With or Without Type 2 Diabetes: Results of a Randomized, Double-Blind, Placebo-Controlled Trial 达格列净在心血管风险患者（无论是否患有2型糖尿病）中的心血管-肾脏效应：一项随机、双盲、安慰剂对照试验的结果

Hypertension

IF8.2

2026-02-01

PREAI

Sridhar, Vikas S.; Kugathasan, Luxcia; Lytvyn, Yuliya; Deng, Yangqing; Liu, Hongyan; Lovblom, Leif Erik; Tse, Josephine; Nardone, Massimo; Floras, John S.; Osuntokun, Tosin; Tobushi, Tomoyuki; Lam, Ruthabella C. Y.; Lam, Brian; Stevens, Jasper; Burger, Dylan; Touw, Daan J.; Heerspink, Hiddo J. L.; Lovshin, Julie A.; Perkins, Bruce A.; Cherney, David Z. I.

Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans 犬全基因组关联研究将DENND1B确定为狗和人类中的肥胖基因

Science

IF45.8

2025-03-28

PREAI

Natalie J. Wallis; Alyce McClellan; Alexander Mörseburg; Katherine A. Kentistou; Aqfan Jamaluddin; Georgina K. C. Dowsett; Ellen Schofield; Anna Morros-Nuevo; Sadia Saeed; Brian Y. H. Lam; Natasha T. Sumanasekera; Justine Chan; Sambhavi S. Kumar; Rey M. Zhang; Jodie F. Wainwright; Marie Dittmann; Gabriella Lakatos; Kara Rainbow; David Withers; Rebecca Bounds; Marcella Ma; Alexander J. German; Jane Ladlow; David Sargan; Philippe Froguel; I. Sadaf Farooqi; Ken K. Ong; Giles S. H. Yeo; John A. Tadross; John R. B. Perry; Caroline M. Gorvin; Eleanor Raffan

Effects of Rare Coding Variants in Severe Early-Onset Obesity Genes in the Population-Based UK Biobank Study 在基于人群的英国生物库研究中，罕见的编码变异对严重早发性肥胖基因的影响

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IF5.1

2025-03-01

OAAI

Jia, Raina Y.; Lockhart, Sam; Lam, Brian Y. H.; Zhao, Yajie; Kentistou, Katherine A.; Gardner, Eugene J.; Farooqi, I. Sadaf; O'Rahilly, Stephen; Day, Felix R.; Ong, Ken K.; Perry, John R. B.

The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system 苯丙胺的代谢和心血管效应部分由中枢黑皮素系统介导。

CELL REPORTS MEDICINE

IF10.6

2025-02-01

OAAI

Simonds, Stephanie E.; Pryor, Jack T.; Lam, Brian Y. H.; Dowsett, Georgina K.; Mustafa, Tomris; Munder, Astrid; Elysee, Kayla; Balland, Eglantine; Cowley, Lachlan O.; Yeo, Giles S. H.; Lawrence, Andrew; Spanswick, David C.; Cowley, Michael A.

Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice

CELL REPORTS

IF6.9

2024-09-01

OAAI

Sandovici, Ionel; Fernandez-Twinn, Denise S.; Campbell, Niamh; Cooper, Wendy N.; Sekita, Yoichi; Zvetkova, Ilona; Ferland-McCollough, David; Prosser, Haydn M.; Oyama, Lila M.; Pantaleao, Lucas C.; Cimadomo, Danilo; de Queiroz, Karina Barbosa; Cheuk, Cecilia S. K.; Smith, Nicola M.; Kay, Richard G.; Antrobus, Robin; Hoelle, Katharina; Ma, Marcella K. L.; Smith, Noel H.; Geyer, Stefan H.; Reissig, Lukas F.; Weninger, Wolfgang J.; Siddle, Kenneth; Willis, Anne E.; Lam, Brian Y. H.; Bushell, Martin; Ozanne, Susan E.; Constancia, Miguel

Comparative proteomics of a versatile, marine, iron-oxidizing chemolithoautotroph

ENVIRONMENTAL MICROBIOLOGY

IF4

2024-06-11

OAAI

Barco, Roman A.; Merino, N.; Lam, B.; Budnik, B.; Kaplan, M.; Wu, F.; Amend, J. P.; Nealson, K. H.; Emerson, D.

Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

CELL METABOLISM

IF30.9

2024-05-01

OAAI

Leeson-Payne, Alasdair; Iyinikkel, Jean; Malcolm, Cameron; Lam, Brian Y. H.; Sommer, Nadine; Dowsett, Georgina K. C.; de Morentin, Pablo B. Martinez; Thompson, Dawn; Mackenzie, Alasdair; Chianese, Raffaella; Kentistou, Katherine; Gardner, Eugene J.; Perry, John R. B.; Grassmann, Felix; Speakman, John R.; Rochford, Justin J.; Yeo, Giles S. H.; Murray, Fiona; Heisler, Lora K.

Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease BSN中的蛋白质截断变体与严重的成人肥胖，2型糖尿病和脂肪肝疾病有关

NATURE GENETICS

IF31.8

2024-04-04

OAAI

Zhao, Yajie; Chukanova, Maria; Kentistou, Katherine A.; Fairhurst-Hunter, Zammy; Siegert, Anna Maria; Jia, Raina Y.; Dowsett, Georgina K. C.; Gardner, Eugene J.; Lawler, Katherine; Day, Felix R.; Kaisinger, Lena R.; Tung, Yi-Chun Loraine; Lam, Brian Yee Hong; Chen, Hsiao-Jou Cortina; Wang, Quanli; Berumen-Campos, Jaime; Kuri-Morales, Pablo; Tapia-Conyer, Roberto; Alegre-Diaz, Jesus; Barroso, Ines; Emberson, Jonathan; Torres, Jason M.; Collins, Rory; Saleheen, Danish; Smith, Katherine R.; Paul, Dirk S.; Merkle, Florian; Farooqi, I. Sadaf; Wareham, Nick J.; Petrovski, Slave; O'Rahilly, Stephen; Ong, Ken K.; Yeo, Giles S. H.; Perry, John R. B.

The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake

MOLECULAR METABOLISM

IF6.6

2024-03-01

OAAI

Alonso, Aldara Martin; Cork, Simon C.; Phuah, Phyllis; Hansen, Benjamin; Norton, Mariana; Cheng, Sijing; Xu, Xiang; Suba, Kinga; Ma, Yue; Dowsett, Georgina K. C.; Tadross, John A.; Lam, Brian Y. H.; Yeo, Giles S. H.; Herzog, Herbert; Bloom, Stephen R.; Arnold, Myrtha; Distaso, Walter; Murphy, Kevin G.; Salem, Victoria

The cichlid pharyngeal jaw novelty enhances evolutionary integration in the feeding apparatus

EVOLUTION

IF2.6

2023-07-07

OAAI

Roberts-Hugghis, Alexus S.; Burress, Edward D.; Lam, Brian; Wainwright, Peter C.

Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene

CELL METABOLISM

IF30.9

2023-07-01

OAAI

Lopez-Tello, Jorge; Yong, Hannah E. J.; Sandovici, Ionel; Dowsett, Georgina K. C.; Christoforou, Efthimia R.; Salazar-Petres, Esteban; Boyland, Rebecca; Napso, Tina; Yeo, Giles S. H.; Lam, Brian Y. H.; Constancia, Miguel; Sferruzzi-Perri, Amanda N.

Prevalence of Deleterious Variants in MC3R in Patients With Constitutional Delay of Growth and Puberty 患有生长和青春期体质延迟的患者中MC3R有害变体的患病率

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IF5.1

2023-06-20

OAAI

Duckett, Katie; Williamson, Alice; Kincaid, John W. R.; Rainbow, Kara; Corbin, Laura J.; Martin, Hilary C.; Eberhardt, Ruth Y.; Huang, Qin Qin; Hurles, Matthew E.; He, Wen; Brauner, Raja; Delaney, Angela; Dunkel, Leo; Grinspon, Romina P.; Hall, Janet E.; Hirschhorn, Joel N.; Howard, Sasha R.; Latronico, Ana C.; Jorge, Alexander A. L.; McElreavey, Ken; Mericq, Veronica; Merino, Paulina M.; Palmert, Mark R.; Plummer, Lacey; Rey, Rodolfo A.; Rezende, Raissa C.; Seminara, Stephanie B.; Salnikov, Kathryn; Banerjee, Indraneel; Lam, Brian Y. H.; Perry, John R. B.; Timpson, Nicholas J.; Clayton, Peter; Chan, Yee-Ming; Ong, Ken K.; O'Rahilly, Stephen

Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice

NATURE COMMUNICATIONS

IF15.7

2023-05-29

OAAI

Ramos-Pittol, Jose M.; Fernandes-Freitas, Isabel; Milona, Alexandra; Manchishi, Stephen M.; Rainbow, Kara; Lam, Brian Y. H.; Tadross, John A.; Beucher, Anthony; Colledge, William H.; Cebola, Ines; Murphy, Kevin G.; Miguel-Aliaga, Irene; Yeo, Giles S. H.; Dhillo, Waljit S.; Owen, Bryn M.

The initiation of mammalian embryonic transcription: to begin at the beginning

TRENDS IN CELL BIOLOGY

IF18.1

2023-05-01

OAAI

Perry, Anthony C. F.; Asami, Maki; Lam, Brian Y. H.; Yeo, Giles S. H.

Biallelic Mutations in P4HTM Cause Syndromic Obesity

DIABETES

IF7.5

2023-04-21

OAAI

Saeed, Sadia; Ning, Lijiao; Badreddine, Alaa; Mirza, Muhammad Usman; Boissel, Mathilde; Khanam, Roohia; Manzoor, Jaida; Janjua, Qasim M.; Khan, Waqas I.; Toussaint, Benedicte; Vaillant, Emmanuel; Amanzougarene, Souhila; Derhourhi, Mehdi; Trant, John F.; Siegert, Anna-Maria; Lam, Brian Y. H.; Yeo, Giles S. H.; Chabraoui, Layachi; Touzani, Asmae; Kulkarni, Abhishek; Farooqi, I. Sadaf; Bonnefond, Amelie; Arslan, Muhammad; Froguel, Philippe

Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression 肥胖药物lorcaserin激活脑干GLP-1神经元以减少食物摄入并增强GLP-1受体激动剂诱导的食欲抑制

MOLECULAR METABOLISM

IF6.6

2023-02-01

OAAI

Wagner, Stefan; Brierley, Daniel I.; Leeson-Payne, Alasdair; Jiang, Wanqing; Chianese, Raffaella; Lam, Brian Y. H.; Dowsett, Georgina K. C.; Cristiano, Claudia; Lyons, David; Reimann, Frank; Gribble, Fiona M.; de Morentin, Pablo B. Martinez; Yeo, Giles S. H.; Trapp, Stefan; Heisler, Lora K.

A program of successive gene expression in mouse one-cell embryos

CELL REPORTS

IF6.9

2023-02-01

OAAI

Asami, Maki; Lam, Brian Y. H.; Hoffmann, Martin; Suzuki, Toru; Lu, Xin; Yoshida, Naoko; Ma, Marcella K.; Rainbow, Kara; Guz, Miodrag; VerMilyea, Matthew D.; Yeo, Giles S. H.; Klein, Christoph A.; Perry, Anthony C. F.

HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus

NATURE METABOLISM

IF20.8

2022-10-20

OAAI

Steuernagel, Lukas; Lam, Brian Y. H.; Klemm, Paul; Dowsett, Georgina K. C.; Bauder, Corinna A.; Tadross, John A.; Hitschfeld, Tamara Sotelo; Martin, Almudena del Rio; Chen, Weiyi; de Solis, Alain J.; Fenselau, Henning; Davidsen, Peter; Cimino, Irene; Kohnke, Sara N.; Rimmington, Debra; Coll, Anthony P.; Beyer, Andreas; Yeo, Giles S. H.; Bruening, Jens C.

Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension (vol 59, 2002463, 2022)

EUROPEAN RESPIRATORY JOURNAL

IF21

2022-07-07

OAAI

Toshner, Mark; Church, Colin; Harbaum, Lars; Rhodes, Christopher; Moreschi, Sofia S. Villar; Liley, James; Jones, Rowena; Arora, Amit; Batai, Ken; Desai, Ankit A.; Coghlan, John G.; Gibbs, J. Simon R.; Gor, Dee; Graf, Stefan; Harlow, Louise; Hernandez-Sanchez, Jules; Howard, Luke S.; Humbert, Marc; Karnes, Jason; Kiely, David G.; Kittles, Rick; Knightbridge, Emily; Lam, Brian; Lutz, Katie A.; Nichols, William C.; Pauciulo, Michael W.; Pepke-Zaba, Joanna; Suntharalingam, Jay; Soubrier, Florent; Trembath, Richard C.; Schwantes-An, Tae-Hwi L.; Wort, S. John; Wilkins, Martin R.; Gaine, Sean; Morrell, Nicholas W.; Corris, Paul A.

研究方向