Robert Newton - Publications, H-index & Citations

Robert Newton

incyte research institute

78H指数

457论文数

2.0W被引数

收录论文 134

发表时间

Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases 发现具有口服生物利用度的异构体选择性Janus激酶1（JAK1）化合物Povorcitinib（INCB054707）用于治疗炎症性和自身免疫性疾病

Journal of Medicinal Chemistry

IF6.8

2026-05-27

PREAI

Jincong Zhuo; Yun-Long Li; Ding-Quan Qian; David M. Burns; Song Mei; Maria Rafalski; Meizhong Xu; Ganfeng Cao; Yongchun Pan; Zhongjiang Jia; Ravi Jalluri; Leslie B. Epling; Gustavo Fenalti; Marc C. Deller; Jessica Procak; Maryanne Covington; Xin He; Robert Collins; Matthew Stubbs; Krista Burke; Julian Oliver; Alex Margulis; Jason Boer; Richard Wynn; Peggy Scherle; Sharon Diamond; Robert Newton; Yan Zhang; Brian Metcalf; Wenqing Yao

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB 炎症细胞因子通过核因子-κB诱导IRF1，促进人肺上皮细胞中干扰素调节因子（IRF）的转录活性。

PLOS ONE

IF2.6

2025-12-08

PREAI

Necker-Brown, Amandah; Mostafa, Mahmoud M.; Georgescu, Andrei; Thorne, Andrew J.; Chandramohan, Priyanka; Kooi, Cora; Kalyanaraman, Keerthana; Gao, Alex; Bansal, Akanksha; Sasse, Sarah K.; Gerber, Anthony N.; Leigh, Richard; Newton, Robert

NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression NF-κB依赖的GR染色质分布重组将GR招募到炎症基因，但与糖皮质激素介导的抑制减弱相关。

iScience

IF4.1

2025-11-25

OAAI

Mahmoud M. Mostafa; Amandah Necker-Brown; Alex Gao; Andrew J. Thorne; Akanksha Bansal; Lucy Swift; Annika M. Maj; Sarah K. Sasse; Pina Colarusso; Anthony N. Gerber; Robert Newton

Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by pro-inflammatory cytokines and glucocorticoid 差异性的 RELA 和 GR 招募至 BIRC3/BIRC2 位点：关于促炎细胞因子和糖皮质激素组合调控的分子洞察

Molecular Pharmacology

IF3

2025-08-28

PREAI

Andrew J. Thorne; Alex Gao; Amandah Necker-Brown; Akanksha Bansal; Keerthana Kalyanaraman; Priyanka Chandramohan; Sarah K. Sasse; Anthony N. Gerber; Mahmoud M. Mostafa; Robert Newton

Genomic crosstalk between carbachol, a muscarinic receptor agonist, and the long-acting 32-adrenoceptor agonist, indacaterol, in human airway epithelial cells 卡巴胆碱（一种毒蕈碱受体激动剂）与长效32-肾上腺素受体激动剂indacaterol在人体气道上皮细胞中的基因组串扰

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-06-01

PREAI

Jayasinghe, Varuna; Joshi, Radhika; Joshi, Taruna; Paracha, Tamkeen U.; Kooi, Cora; Mostafa, Mahmoud M.; Bauer, Carla M. T.; Charlton, Steven J.; Iartchouk, Oleg; Maillet, Ashley; Morris, Melody K.; Ruda, Vera M.; Sandham, David A.; Wang, Yanqun; Newton, Robert; Giembycz, Mark A.

Comparison of the Genomic Activity of an EP4-Receptor and b2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene ExpressionS

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2024-10-01

OAAI

Joshi, Radhika; Paracha, Tamkeen U.; Mostafa, Mahmoud M.; Thorne, Andrew J.; Jayasinghe, Varuna; Yan, Dong; Hamed, Omar; Newton, Robert; Giembycz, Mark A.

Inducible gene expression of IκB-kinase ε is dependent on nuclear factor-κB in human pulmonary epithelial cells

BIOCHEMICAL JOURNAL

IF4.3

2024-07-12

OAAI

Necker-Brown, Amandah; Kooi, Cora; Thorne, Andrew J.; Bansal, Akanksha; Mostafa, Mahmoud M.; Chandramohan, Priyanka; Gao, Alex; Kalyanaraman, Keerthana; Milani, Arya; Gill, Sachman; Georgescu, Andrei; Sasse, Sarah K.; Gerber, Anthony N.; Leigh, Richard; Newton, Robert

Synergy between Interleukin-1#, Interferon-y, and Glucocorticoids to Induce TLR2 Expression Involves NF-KB, STAT1, and the Glucocorticoid Receptor

MOLECULAR PHARMACOLOGY

IF3

2024-01-01

OAAI

Bansal, Akanksha; Kooi, Cora; Kalyanaraman, Keerthana; Gill, Sachman; Thorne, Andrew; Chandramohan, Priyanka; Necker-Brown, Amandah; Mostafa, Mahmoud M.; Milani, Arya; Leigh, Richard; Newton, Robert

Interplay between nuclear factor-KB, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-04-01

OAAI

Bansal, Akanksha; Mostafa, Mahmoud M.; Kooi, Cora; Sasse, Sarah K.; Michi, Aubrey N.; Shah, Suharsh, V; Leigh, Richard; Gerber, Anthony N.; Newton, Robert

NF-κB and Glucocorticoid Receptor Synergize to Enable Pro-inflammatory Signaling via Toll-like Receptor 2 in Pulmonary Epithelial Cells

FASEB JOURNAL

IF4.2

2021-05-14

PREAI

Bansal, Akanksha; Kooi, Cora; Mostafa, Mahmoud; Gerber, Anthony; Leigh, Richard; Newton, Robert

Differential regulation of baculoviral repeat containing protein 2 (BIRC2) and 3 (BIRC3) by inflammatory stimuli and glucocorticoids

FASEB JOURNAL

IF4.2

2021-05-14

PREAI

Thorne, Andrew; Mostafa, Mahmoud; Bansal, Akanksha; Newton, Robert

Role of nuclear factor-κB (NF-κB) in the regulation of pro-inflammatory IκB-kinase-ε (IKKε)gene expression in human pulmonary epithelial cells

FASEB JOURNAL

IF4.2

2021-05-14

PREAI

Necker-Brown, Amandah; Thorne, Andrew; Bansal, Akanksha; Mostafa, Mahmoud; Gerber, Anthony; Newton, Robert

Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β2-Adrenoceptor Agonist Combination Therapy in Asthma

MOLECULAR PHARMACOLOGY

IF3

2021-03-01

OAAI

Mostafa, Mahmoud M.; Rider, Christopher F.; Wathugala, N. Dulmini; Leigh, Richard; Giembycz, Mark A.; Newton, Robert

Clinicogenomic Analysis of FGFR2-Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib FGFR2-Rearranged胆管癌的临床基因组分析确定了对Pemigatinib的反应和耐药机制的相关性

CANCER DISCOVERY

IF33.3

2021-02-02

186

OAAI

Silverman, Ian M.; Hollebecque, Antoine; Friboulet, Luc; Owens, Sherry; Newton, Robert C.; Zhen, Huiling; Feliz, Luis; Zecchetto, Camilla; Melisi, Davide; Burn, Timothy C.

Prostanoid Receptors of the EP4-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2021-02-01

OAAI

Joshi, Radhika; Hamed, Omar; Yan, Dong; Michi, Aubrey N.; Mostafa, Mahmoud M.; Wiehler, Shahina; Newton, Robert; Giembycz, Mark A.

Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Gerber, Anthony N.; Newton, Robert; Sasse, Sarah K.

Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Mostafa, Mahmoud M.; Bansal, Akanksha; Michi, Aubrey N.; Sasse, Sarah K.; Proud, David; Gerber, Anthony N.; Newton, Robert

RETROSPECTIVE POOLED ANALYSIS OF EPACADOSTAT CLINICAL STUDIES IDENTIFIES DOSES REQUIRED FOR MAXIMAL PHARMACODYNAMIC EFFECT IN ANTI-PD-1 COMBINATION STUDIES

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2020-12-10

PREAI

Smith, Michael; Newton, Robert; Owens, Sherry; Gong, Xiaohua; Tian, Chuan; Maleski, Janet; Leopold, Lance

Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2020-10-01

PREAI

Covington, Maryanne; He, Xin; Scuron, Monika; Li, Jun; Collins, Robert; Juvekar, Ashish; Shin, Niu; Favata, Margaret; Gallagher, Karen; Sarah, Sarala; Xue, Chu-biao; Peel, Michael; Burke, Krista; Oliver, Julian; Fay, Brittany; Yao, Wenqing; Huang, Taisheng; Scherle, Peggy; Diamond, Sharon; Newton, Robert; Zhang, Yan; Smith, Paul

Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2020-07-01

OAAI

Shin, Niu; Stubbs, Matthew; Koblish, Holly; Yue, Eddy W.; Soloviev, Maxim; Douty, Brent; Wang, Kathy He; Wang, Qian; Gao, Mingming; Feldman, Patricia; Yang, Gengjie; Hall, Leslie; Hansbury, Michael; O'Connor, Sybil; Leffet, Lynn; Collins, Robert; Katiyar, Kamna; He, Xin; Waeltz, Paul; Collier, Paul; Lu, Jin; Li, Yun-Long; Li, Yanlong; Liu, Phillip C. C.; Burn, Timothy; Covington, Maryanne; Diamond, Sharon; Shuey, Dana; Roberts, Alan; Yeleswaram, Swamy; Hollis, Greg; Metcalf, Brian; Yao, Wenqing; Huber, Reid; Combs, Andrew; Newton, Robert; Scherle, Peggy

研究方向