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O

Olivia M. Merkel

ludwig-maximilians-university

50H指数
220论文数
7.7K被引数
收录论文 114
发表时间
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Tailoring Zein-based lipid–polymer hybrid vectors for efficient pulmonary siRNA delivery by nebulization通过雾化递送，定制基于玉米醇溶蛋白的脂质-聚合物杂化载体以实现高效的肺siRNA递送
errEuropean Polymer Journal
IF6.3
err2026-08-31
err0
errOAAI
errSofia Bonsignore; Min Jiang; Salvatore Emanuele Drago; Cinzia Scialabba; Leonie Deßloch; Sebastian Sturm; Emanuela Fabiola Craparo; Knut Müller-Caspary; Olivia M. Merkel; Gennara Cavallaro
err分享
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Utilizing chitosan nanoparticles for the delivery of biologics to the brain via intranasal route利用壳聚糖纳米粒子通过鼻内途径向大脑递送生物制剂
errMaterials Today Advances
IF8
err2026-07-07
err0
errOAAI
errBettina Gabold; Irene Gialdini; Igor Khalin; Antonietta Greco; Adrian Kromer; Xiaoxuan Wang; Lea-Adriana Barlang; Andreas Popp; Christian L. Ried; Thomas Merdan; Nikolaus Plesnila; Don C. Lamb; Olivia M. Merkel
err分享
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mRNA Delivery by Lipoamino Fatty Acid–Peptide Polyplexes in Different Lung Cell Models and Lungs脂氨基酸-肽聚合物复合物在不同肺细胞模型和肺中的mRNA递送
errPolymers
IF4.9
err2026-05-31
err0
errOAAI
errSophie Thalmayr; Joschka Müller; Vivien Polewka; Irene Gialdini; Anny Nguyen; Christian Dohmen; Don C. Lamb; Olivia M. Merkel; Ernst Wagner
err分享
err收藏
Meta-Learning as a Promising Strategy for Lipid Nanoparticle Optimization and Ionizable Lipid Discovery元学习作为脂质纳米颗粒优化和可电离脂质发现的有前景策略
errNano Letters
IF9.1
err2026-05-21
err0
errOAAI
errFelix Sieber-Schäfer; Lasse Hagedorn; Leon Reger; Katharina Möbius; Benjamin Winkeljann; Olivia M. Merkel
err分享
err收藏
Chemical topology of lipo-amino fatty acid mRNA carriers triggers distinct lipid bulk phases and endosomal escape mechanisms脂肽脂肪酸mRNA载体的化学拓扑结构触发不同的脂质体相和内体逃逸机制
errMaterials Today
IF22
err2026-04-27
err0
errOAAI
errMelina Grau; Ekaterina Kostyurina; Johanna Seidl; Nora Martini; Benjamin Winkeljann; Olivia M. Merkel; Joachim O. Rädler; Ernst Wagner
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New insights into the intrinsic tryptophan fluorescence emission spectra of IgG antibodies and the impact of protein unfolding and aggregationIgG抗体固有色氨酸荧光发射光谱的新见解以及蛋白质变性聚集的影响
errEuropean Journal of Pharmaceutics and Biopharmaceutics
IF4.3
err2026-04-18
err0
PREAI
errLennart Brack; Jonas Binder; Irene Gialdini; Don C. Lamb; Wolfgang Friess; Olivia M. Merkel; Rudolf Schroeder
err分享
err收藏
Drug Product Development of Lipid Nanoparticle-Based mRNA Therapeutics and Vaccines基于脂质纳米颗粒的mRNA治疗药物和疫苗的产品开发
errWIREs Nanomedicine and Nanobiotechnology
IF0
err2026-02-27
err0
errOAAI
errGideon Kersten; Eleonora Cerasoli; Bruce Kerwin; Olivia M. Merkel; Andrea Hawe
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Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo疏水性精炼调节极性可切换的脂质异种肽，调控内体逃逸并增强体内和体外mRNA递送
errJournal of the American Chemical Society
IF15.6
err2026-02-25
err0
PREAI
errTobias Burghardt; Sophie Thalmayr; Lennart Obeser; Jana Pöhmerer; Mina Yazdi; Miriam Höhn; Matthias Völkl; Felix Sieber-Schäfer; Stefan Zahler; Olivia M. Merkel; Daniel Merk; Ernst Wagner
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Modulating mRNA carrier efficacy through the molecular catwalk of ionizable nitrogens in lipidic domains
errJournal of Colloid and Interface Science
IF9.7
err2026-01-24
err0
errOAAI
errMelina Grau; Nora Martini; Sophie Thalmayr; Miriam Höhn; Olivia M. Merkel; Benjamin Winkeljann; Ernst Wagner
err分享
err收藏
Optimized lipid nanoparticles for pulmonary delivery of CRISPR/Cas9 targeting KRAS G12S in lung cancer用于肺靶向递送靶向KRAS G12S的CRISPR/Cas9的优化脂质纳米颗粒
errJournal of Controlled Release
IF11.5
err2026-01-06
err0
errOAAI
errMoritz Marschhofer; Siyu Chen; Müge Molbay; Benjamin Winkeljann; Ersilia Villano; Corinne Giancaspro; Alexandra Kourou; Otto Berninghausen; Susanne Rieder; Charlotte Ungewickell; Roland Beckmann; Bastian Popper; Ana Maria Torres; Anxo Vidal; Olivia M. Merkel; Simone P. Carneiro
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Engineering access to the brain: nanotechnologies at the interface of delivery, neurology, and immunotherapy工程化大脑通路：递送、神经病学与免疫治疗交叉领域的纳米技术
errDrug Delivery and Translational Research
IF5.5
err2026-01-06
err0
errOAAI
errOlivia M. Merkel; Shang-Hsiu Hu; Cristina Fornaguera
err分享
err收藏
QbD product development: rapid optimization and scale-up of PBAE-based siRNA delivery via DoE-guided microfluidicsQbD产品开发：通过DoE指导的微流控技术实现PBAE基siRNA递送的快速优化与放大
errRSC Pharmaceutics
IF0
err2026-01-01
err0
errOAAI
errKromer, Adrian P. E.; Eller, Laetitia J. M.; Jurgens, David C.; Merkel, Olivia M.
err分享
err收藏
Understanding excipient interactions unlocks untapped potential of RNA-lipid nanoparticles in dry powder formulations for local pulmonary delivery理解赋形剂相互作用可释放RNA-脂质纳米颗粒在干粉制剂中用于局部肺递送方面的未开发潜力。
errJournal of Controlled Release
IF11.5
err2025-12-12
err0
errOAAI
errNora Martini; Leonie Deßloch; Taras Sych; Otto Berninghausen; J. Merl-Pham; Sjoerd Dijkstra; Simone P. Carneiro; Marion Frankenberger; Roland Beckmann; Jürgen Behr; Gabriele Matschiner; Christine Schuberth-Wagner; A. Önder Yildirim; David C. Jürgens; Erdinc Sezgin; Olivia M. Merkel; Benjamin Winkeljann
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Impact of Formulation and Process Parameters on the Stability and Bioactivity of RNA-Loaded Lipid Nanoparticles during Nebulization制剂和工艺参数对RNA负载脂质纳米粒在雾化过程中稳定性和生物活性的影响
errEuropean Journal of Pharmaceutical Sciences
IF4.7
err2025-11-19
err0
errOAAI
errKatrin F. Wiebe; Stefan Schneid; Werner Hoheisel; Wolfgang Frieß; Olivia M. Merkel
err分享
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From Bits to Bonds: High-Throughput Virtual Screening of Ribonucleic Acid Nanocarriers Using a Combinatorial Approach of Machine Learning and Molecular Dynamics从比特到键合：利用机器学习与分子动力学相结合的组合方法对核糖核酸纳米载体进行高通量虚拟筛选
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2025-11-01
err0
PREAI
errSieber-Schafer, Felix; Binder, Jonas; Munchrath, Tim; Steinegger, Katharina M.; Jiang, Min; Winkeljann, Benjamin; Friess, Wolfgang; Merkel, Olivia M.
err分享
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Design of an Injectable and Bioerodible Supramolecular Hydrogel as a Local Nucleic Acid Delivery System设计一种可注射且生物可降解的超分子水凝胶作为局部核酸递送系统
errACS APPLIED POLYMER MATERIALS
IF4.7
err2025-11-01
err0
PREAI
errCoppola, Paola Grillo; Kromer, Adrian Philipp Eckart; Boffito, Monica; Winkeljann, Benjamin; Ciardelli, Gianluca; Merkel, Olivia M.
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Development of Trastuzumab-coupled, siRNA encapsulating mPolyplexes targeting HER2 overexpressing cancer cells靶向HER2过表达癌细胞的曲妥珠单抗偶联、siRNA包封的多聚复合物开发
errEuropean Journal of Pharmaceutics and Biopharmaceutics
IF4.3
err2025-10-28
err0
errOAAI
errJoschka T. Müller; Salvatore Caruso; Anny Nguyen; David C. Jürgens; Adrian P.E. Kromer; Sahana Sheshachala; Nathan B.P. Adams; Olivia M. Merkel
err分享
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Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC两孔通道2的缺失通过MAPK轴增强CD8+ T细胞细胞毒性并直接抑制肝癌肿瘤生长
errFrontiers in Immunology
IF5.9
err2025-10-24
err0
errOAAI
errLina Ouologuem; Anna Kübler; Sarah Ouologuem; Amar Hadzic; Jan B. Stöckl; Anna Chiara Siciliano; Stefania Forciniti; Salvatore Nigro; Helena Iuele; Valentina Onesto; Anny Nguyen; Dana Matzek; Carla Abrahamian; Christian Grimm; Bastian Popper; Giuseppe Gigli; Loretta L. del Mercato; Olivia M. Merkel; Thomas Fröhlich; Sebastian Theurich; Karin Bartel
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Spermine-Based Nanocarriers for siRNA Delivery in Fibroblast-Driven Diseases: A Proof-of-Concept Study基于精胺的纳米载体在成纤维细胞驱动疾病中的siRNA递送：一项概念验证研究
errMACROMOLECULAR CHEMISTRY AND PHYSICS
IF2.7
err2025-10-01
err0
PREAI
errReger, Leon; Giglio, Alessia; Hommel, Johannes; Chiesa, Enrica; Sgarbi, Elisa; Marchini, Gessica; Pizzirani, Daniela; Pinto Carneiro, Simone; Genta, Ida; Adams, Friederike; Merkel, Olivia M.
err分享
err收藏
Photothermally Powered 3D Microgels Mechanically Regulate Mesenchymal Stem Cells Under Anisotropic Force光热驱动的3D微凝胶在非均匀力条件下机械调控间充质干细胞
errAdvanced Materials
IF26.8
err2025-09-24
err0
errOAAI
errChen Wang; Nergishan İyisan; Philipp Harder; Valentin H. K. Fell; Viktorija Kozina; Hendrik Dietz; Olivia M. Merkel; Berna Özkale
err分享
err收藏

研究方向

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合作学者
合作期刊
R
Róbert Langer
H 指数: 262 · 论文数: 2.0K
刘豫 封面图
刘豫 (Yu Liu)
H 指数: 116 · 论文数: 2.7K
P
Pieter R. Cullis
H 指数: 108 · 论文数: 478
R
Rainer Müller
H 指数: 105 · 论文数: 625
M
Mark R. Prausnitz
H 指数: 105 · 论文数: 446
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