Janet R. Kumita - Publications, H-index & Citations

Janet R. Kumita

university of cambridge

45H指数

137论文数

6.9K被引数

收录论文 52

发表时间

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates 调节理性设计蛋白质基生物分子凝聚体的物理化学性质

Current Opinion in Structural Biology

IF7

2026-06-20

OAAI

Nora A. Leclercq Haanæs; Janet R. Kumita

Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilizing Effects on the Scaffold PR65 小分子蛋白磷酸酶2A激活剂对支架PR65产生全局稳定效应

JACS Au

IF8.7

2026-04-20

OAAI

Mohsin M. Naqvi; Maria Zacharopoulou; Satyaki Saha; Anupam Banerjee; Sema Z. Yilmaz; Vanda Sunderlikova; Chris M. Johnson; Janet R. Kumita; Shang-Hua Yang; Reuven Gordon; Michael Ohlmeyer; Sander J. Tans; Mert Gur; Ivet Bahar; Laura S. Itzhaki

Microscopy-based techniques for studying the material properties of biomolecular condensates in the cellular environment 基于显微术的技术，用于研究细胞环境中生物分子凝聚体的材料属性。

Biophysical Reviews

IF3.7

2025-07-28

OAAI

Tin Long Chris Ng; Luisa Capalbo; Janet R. Kumita

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non-Native Amide-π Interactions 淀粉样蛋白形成的人溶菌酶中间体通过非天然酰胺-π相互作用得到稳定

Advanced Science

IF14.1

2025-06-25

OAAI

Minkoo Ahn; Julian O. Streit; Christopher A. Waudby; Tomasz Włodarski; Angelo Miguel Figueiredo; John Christodoulou; Janet R. Kumita

Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils 使用稳定的蛋白质骨架展示与α-突触核蛋白纤维结合的肽段

PROTEIN SCIENCE

IF5.2

2025-05-15

OAAI

Bismut, Samuel; Schneider, Matthias M.; Miyasaki, Masashi; Feng, Yuqing; Wilde, Ellis J.; Gunawardena, M. Dylan; Knowles, Tuomas P. J.; Schierle, Gabrielle S. Kaminski; Itzhaki, Laura S.; Kumita, Janet R.

Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates 串联重复蛋白为工程生物分子凝聚体引入了可调谐的特性。

CHEMICAL SCIENCE

IF7.4

2025-01-01

OAAI

Ng, Tin Long Chris; Hoare, Mateo P.; Maristany, M. Julia; Wilde, Ellis J.; Sneideris, Tomas; Huertas, Jan; Agbetiameh, Belinda K.; Furukawa, Mona; Joseph, Jerelle A.; Knowles, Tuomas P. J.; Collepardo-Guevara, Rosana; Itzhaki, Laura S.; Kumita, Janet R.

α-Synuclein Oligomers Displace Monomeric α-Synuclein from Lipid Membranes Α-突触核蛋白寡聚体从脂质膜中置换单体 α-突触核蛋白

ACS NANO

IF16

2024-06-25

OAAI

Sneideriene, Greta; Czekalska, Magdalena A.; Xu, Catherine K.; Jayaram, Akhila K.; Krainer, Georg; Arter, William E.; Peter, Quentin A. E.; Castellana-Cruz, Marta; Saar, Kadi Liis; Levin, Aviad; Mueller, Thomas; Fiedler, Sebastian; Devenish, Sean R. A.; Fiegler, Heike; Kumita, Janet R.; Knowles, Tuomas P. J.

Influence of point mutations on PR65 conformational adaptability: Insights from molecular simulations and nanoaperture optical tweezers

SCIENCE ADVANCES

IF12.5

2024-05-31

OAAI

Banerjee, Anupam; Mathew, Samuel; Naqvi, Mohsin M.; Yilmaz, Sema Z.; Zacharopoulou, Maria; Doruker, Pemra; Kumita, Janet R.; Yang, Shang-Hua; Gur, Mert; Itzhaki, Laura S.; Gordon, Reuven; Bahar, Ivet

Phase separation and molecular ordering of the prion-like domain of the Arabidopsis thermosensory protein EARLY FLOWERING 3

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-07-03

OAAI

Hutin, Stephanie; Kumita, Janet R.; Strotmann, Vivien I.; Dolata, Anika; Ling, Wai Li; Louafi, Nessim; Popov, Anton; Milhiet, Pierre- Emmanuel; Blackledge, Martin; Nanao, Max H.; Wigge, Philip A.; Stahl, Yvonne; Costa, Luca; Tully, Mark D.; Zubieta, Chloe

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity Α-突触核蛋白寡聚体中的病理性G51D突变赋予不同的结构属性和细胞毒性

MOLECULES

IF4.6

2022-02-15

OAAI

Xu, Catherine K.; Castellana-Cruz, Marta; Chen, Serene W.; Du, Zhen; Meisl, Georg; Levin, Aviad; Mannini, Benedetta; Itzhaki, Laura S.; Knowles, Tuomas P. J.; Dobson, Christopher M.; Cremades, Nunilo; Kumita, Janet R.

Different Folding States from the Same Protein Sequence Determine Reversible vs Irreversible Amyloid Fate

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-07-21

PREAI

Cao, Yiping; Adamcik, Jozef; Diener, Michael; Kumita, Janet R.; Mezzenga, Raffaele

Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans 外源错误折叠的蛋白寡聚物可以穿过肠道屏障并在秀丽隐杆线虫中引起疾病表型

SCIENTIFIC REPORTS

IF3.9

2021-07-13

OAAI

Perni, Michele; Mannini, Benedetta; Xu, Catherine K.; Kumita, Janet R.; Dobson, Christopher M.; Chiti, Fabrizio; Vendruscolo, Michele

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers 角鲨胺及其衍生物调节 β 淀粉样蛋白和 α-突触核蛋白的聚集并抑制其低聚物的毒性

FRONTIERS IN NEUROSCIENCE

IF3.2

2021-06-18

OAAI

Limbocker, Ryan; Staats, Roxine; Chia, Sean; Ruggeri, Francesco S.; Mannini, Benedetta; Xu, Catherine K.; Perni, Michele; Cascella, Roberta; Bigi, Alessandra; Sasser, Liam R.; Block, Natalie R.; Wright, Aidan K.; Kreiser, Ryan P.; Custy, Edward T.; Meisl, Georg; Errico, Silvia; Habchi, Johnny; Flagmeier, Patrick; Kartanas, Tadas; Hollows, Jared E.; Nguyen, Lam T.; LeForte, Kathleen; Barbut, Denise; Kumita, Janet R.; Cecchi, Cristina; Zasloff, Michael; Knowles, Tuomas P. J.; Dobson, Christopher M.; Chiti, Fabrizio; Vendruscolo, Michele

Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme 人溶菌酶的W64R淀粉样蛋白变体的结构，动力学和聚集特性的表征

BIOPHYSICAL CHEMISTRY

IF2.2

2021-04-01

OAAI

Vettore, Nicola; Moray, Joel; Brans, Alain; Herman, Raphael; Charlier, Paulette; Kumita, Janet R.; Kerff, Frederic; Dobson, Christopher M.; Dumoulin, Mireille

A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers (vol 4, 19, 2021)多巴胺代谢物稳定神经毒性淀粉样 β 寡聚体 (第4、19、2021卷)

COMMUNICATIONS BIOLOGY

IF5.1

2021-01-26

OAAI

Cataldi, Rodrigo; Chia, Sean; Pisani, Katarina; Ruggeri, Francesco S.; Xu, Catherine K.; Sneideris, Tomas; Perni, Michele; Sarwat, Sunehera; Joshi, Priyanka; Kumita, Janet R.; Linse, Sara; Habchi, Johnny; Knowles, Tuomas P. J.; Mannini, Benedetta; Dobson, Christopher M.; Vendruscolo, Michele

A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers 多巴胺代谢物稳定神经毒性淀粉样 β 寡聚体

COMMUNICATIONS BIOLOGY

IF5.1

2021-01-04

OAAI

Engineering mono- and multi-valent inhibitors on a modular scaffold

CHEMICAL SCIENCE

IF7.4

2021-01-01

OAAI

Diamante, Aurora; Chaturbedy, Piyush K.; Rowling, Pamela J. E.; Kumita, Janet R.; Eapen, Rohan S.; McLaughlin, Stephen H.; Roche, Marc de la; Perez-Riba, Albert; Itzhaki, Laura S.

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution 溶液中 α-突触核蛋白低聚物的快速结构，动力学和免疫化学分析

NANO LETTERS

IF9.1

2020-10-20

OAAI

Arter, William E.; Xu, Catherine K.; Castellana-Cruz, Marta; Herling, Therese W.; Krainer, Georg; Saar, Kadi L.; Kumita, Janet R.; Dobson, Christopher M.; Knowles, Tuomas P. J.

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism Trodusquemine从细胞膜上置换蛋白质错误折叠的低聚物，并通过通用机制消除其细胞毒性

COMMUNICATIONS BIOLOGY

IF5.1

2020-08-13

OAAI

Limbocker, Ryan; Mannini, Benedetta; Ruggeri, Francesco S.; Cascella, Roberta; Xu, Catherine K.; Perni, Michele; Chia, Sean; Chen, Serene W.; Habchi, Johnny; Bigi, Alessandra; Kreiser, Ryan P.; Wright, Aidan K.; Albright, J. Alex; Kartanas, Tadas; Kumita, Janet R.; Cremades, Nunilo; Zasloff, Michael; Cecchi, Cristina; Knowles, Tuomas P. J.; Chiti, Fabrizio; Vendruscolo, Michele; Dobson, Christopher M.

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils Α-突触核蛋白的致病性突变对淀粉样原纤维的生物物理和结构特征的影响

ACS NANO

IF16

2020-03-11

OAAI

Ruggeri, Francesco Simone; Flagmeier, Patrick; Kumita, Janet R.; Meisl, Georg; Chirgadze, Dimitri Y.; Bongiovanni, Marie N.; Knowles, Tuomas P. J.; Dobson, Christopher M.

研究方向