logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
X

Xavier Barril

gain therapeutics

43H指数
186论文数
7.3K被引数
收录论文 72
发表时间
logo
Development of Small-Molecule Allosteric Modulators of Beta-Galactosidase (β-Gal) for the Treatment of GM1 Gangliosidosis and Morquio B开发用于治疗GM1神经节苷脂病和莫尔基奥B病的β-半乳糖苷酶(β-Gal)小分子别构调节剂
errInternational Journal of Molecular Sciences
IF4.9
err2026-04-18
err0
errOAAI
errNatàlia Pérez-Carmona; Elena Cubero; Ana Ruano; Maria Pons-Vizcarra; Aida Delgado; Ana Trapero; Marc Reves; Laura Rodríguez-Pascau; Joanne Taylor; Marc Martinell; Xavier Barril; Ana María García-Collazo
err分享
err收藏
Water Networks as Hydrophobic Recognition Motifs in Proteins水网络作为蛋白质中的疏水识别基序
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2025-11-01
err0
errOAAI
errPiticchio, Serena G.; Martinez-Cartro, Miriam; Scaffidi, Salvatore; Rodriguez-Arevalo, Sergio; Bagan, Andrea; Sanchez-Arfelis, Ainoa; Picaud, Sarah; Krojer, Tobias; Filippakopoulos, Panagis; von Delft, Frank; Escolano, Carmen; Galdeano, Carles; Barril, Xavier
err分享
err收藏
Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators发现E3连接酶上未探索的结合口袋导致FBW7别构调节剂的鉴定
errAdvanced Science
IF14.1
err2025-08-20
err0
errOAAI
errMíriam Martínez-Cartró; Álvaro Serrano-Morrás; Andrea Bertran-Mostazo; Roger Castaño-Muñiz; Salvatore Scaffidi; Varbina Ivanova; Noémi Csorba; József Simon; Péter Ábrányi-Balogh; Yunfeng Li; György M. Keserü; Bing Hao; Xavier Barril; Carles Galdeano
err分享
err收藏
A bottom-up approach to find lead compounds in expansive chemical spaces一种自下而上的方法，用于在广阔的化学空间中寻找先导化合物
errCommunications Chemistry
IF6.2
err2025-08-01
err0
errOAAI
errÁlvaro Serrano-Morrás; Andrea Bertran-Mostazo; Marina Miñarro-Lleonar; Arnau Comajuncosa-Creus; Adrià Cabello; Carme Labranya; Carmen Escudero; Tian V. Tian; Inna Khutorianska; Dmytro S. Radchenko; Yurii S. Moroz; Lucas Defelipe; David Ruiz-Carrillo; Maria Garcia-Alai; Robert Schmidt; Matthias Rarey; Patrick Aloy; Carles Galdeano; Jordi Juárez-Jiménez; Xavier Barril
err分享
err收藏
The Quasi-Bound State as a Predictor of Relative Binding Free Energy准束缚态作为相对结合自由能的预测因子
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-05-20
err0
PREAI
errSerrano-Morras, Alvaro; Westermaier, Yvonne; Majewski, Maciej; Barril, Xavier
err分享
err收藏
Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2025-02-01
err0
errOAAI
errFitzgerald, Edward A.; Rachman, Moira M.; Cederfelt, Daniela; Myers, Nadine E. M.; Kovryzchenko, Daria; Zhang, He; Barril, Xavier; Koehler, Konrad; Danielson, U. Helena
err分享
err收藏
Identification of allosteric inhibitors targeting Discoidin Domain Receptor 2 (DDR2)
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errCano, S.; Carrillo, J.; Alvarez, D.; Barril, X.; Cubero, E.; Belloto, M.; Garcia-Collazo, A. M.; Perez-Carmona, N.; Taylor, J.
err分享
err收藏
Use of the Novel Site-Directed Enzyme Enhancement Therapy (SEE-Tx) Drug Discovery Platform to Identify Pharmacological Chaperones for Glutaric Acidemia Type 1
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-23
err0
errOAAI
errBarroso, Madalena; Puchwein-Schwepcke, Alexandra; Buettner, Lars; Goebel, Ingrid; Kuechler, Katrin; Muntau, Ania C.; Delgado, Aida; Garcia-Collazo, Ana M.; Martinell, Marc; Barril, Xavier; Cubero, Elena; Gersting, Soren W.
err分享
err收藏
The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity
errCHEMMEDCHEM
IF3.4
err2024-09-12
err0
PREAI
errBlaazer, Antoni R.; Singh, Abhimanyu K.; Zara, Lorena; Boronat, Pierre; Bautista, Lady J.; Irving, Steve; Majewski, Maciej; Barril, Xavier; Wijtmans, Maikel; Danielson, U. Helena; Sterk, Geert Jan; Leurs, Rob; van Muijlwijk-Koezen, Jacqueline E.; Brown, David G.; de Esch, Iwan J. P.
err分享
err收藏
Comprehensive detection and characterization of human druggable pockets through binding site descriptors
errNATURE COMMUNICATIONS
IF15.7
err2024-09-10
err1
errOAAI
errComajuncosa-Creus, Arnau; Jorba, Guillem; Barril, Xavier; Aloy, Patrick
err分享
err收藏
Multi-Responsive Eight-State Bis(acridinium-Zn(II) porphyrin) Receptor
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-05-08
err1
errOAAI
errEdo-Osagie, Amy; Serillon, Dylan; Ruani, Federica; Barril, Xavier; Gourlaouen, Christophe; Armaroli, Nicola; Ventura, Barbara; Rouville, Henri-Pierre Jacquot de; Heitz, Valerie
err分享
err收藏
Lenalidomide Stabilizes Protein-Protein Complexes by Turning Labile Intermolecular H-Bonds into Robust Interactions
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-04-21
err7
errOAAI
errMinarro-Lleonar, Marina; Bertran-Mostazo, Andrea; Duro, Jorge; Barril, Xavier; Juarez-Jimenez, Jordi
err分享
err收藏
A structurally targeted allosteric regulator of GCase restores enzyme activity, reduces microgliosis, and improves fine locomotor skills in the CBE model of neuronopathic Gaucher disease
errMOLECULAR GENETICS AND METABOLISM
IF3.5
err2023-02-01
err0
PREAI
errGuzman, Beatriz; Perez, Natalia; Garcia-Collazo, Ana Maria; Cubero, Elena; Barril, Xavier; Bellotto, Manolo; Taylor, Joanne
err分享
err收藏
Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-06-23
err4
errOAAI
errBurastero, Osvaldo; Defelipe, Lucas A.; Gola, Gabriel; Tateosian, Nancy L.; Lopez, Elias D.; Martinena, Camila Belen; Arcon, Juan Pablo; Traian, Martin Dodes; Wetzler, Diana E.; Bento, Isabel; Barril, Xavier; Ramirez, Javier; Marti, Marcelo A.; Garcia-Alai, Maria M.; Turjanski, Adrian G.
err分享
err收藏
Computational Design of Inhibitors Targeting the Catalytic β Subunit of Escherichia coli FOF1-ATP Synthase
errANTIBIOTICS-BASEL
IF4.6
err2022-04-22
err8
errOAAI
errPablo Avila-Barrientos, Luis; Fernando Cofas-Vargas, Luis; Aguero-Chapin, Guillermin; Hernandez-Garcia, Enrique; Ruiz-Carmona, Sergio; Valdez-Cruz, Norma A.; Trujillo-Roldan, Mauricio; Weber, Joachim; Ruiz-Blanco, Yasser B.; Barril, Xavier; Garcia-Hernandez, Enrique
err分享
err收藏
Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-12-13
err7
PREAI
errPiticchio, Serena G.; Martinez-Cartro, Miriam; Scaffidi, Salvatore; Rachman, Moira; Rodriguez-Arevalo, Sergio; Sanchez-Arfelis, Ainoa; Escolano, Carmen; Picaud, Sarah; Krojer, Tobias; Filippakopoulos, Panagis; von Delft, Frank; Galdeano, Carles; Barril, Xavier
err分享
err收藏
Testing automatic methods to predict free binding energy of host-guest complexes in SAMPL7 challenge
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2021-01-19
err7
errOAAI
errSerillon, Dylan; Bo, Carles; Barril, Xavier
err分享
err收藏
Structural Stability Predicts the Binding Mode of Protein-Ligand Complexes
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2020-02-13
err15
PREAI
errMajewski, Maciej; Barril, Xavier
err分享
err收藏
Brain penetrant structurally targeted allosteric regulators for treating GLB1-related disorders
errMOLECULAR GENETICS AND METABOLISM
IF3.5
err2020-02-01
err0
PREAI
errBellotto, Manolo; Maj, Roberto; Maria Garcia-Collazo, Ana; Ruano, Ana; Delgado, Aida; Morales, Sara; Cubero, Elena; Perez-Carmona, Natalia; Barril, Xavier
err分享
err收藏
Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
errCHEMICAL SCIENCE
IF7.4
err2020-01-01
err42
errOAAI
errSubiros-Funosas, Ramon; Ho, Vivian Cheuk Lam; Barth, Nicole D.; Mendive-Tapia, Lorena; Pappalardo, Morena; Barril, Xavier; Ma, Ruoyu; Zhang, Cheng-Bin; Qian, Bin-Zhi; Sintes, Miquel; Ghashghaei, Ouldouz; Lavilla, Rodolfo; Vendrell, Marc
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
M
Manel Esteller
H 指数: 165 · 论文数: 1.6K
P
Paul Workman
H 指数: 106 · 论文数: 1.2K
Y
Yusuke Nakamura
H 指数: 104 · 论文数: 590
J
John A. Katzenellenbogen
H 指数: 100 · 论文数: 1.0K
D
Dennis C. Sgroi
H 指数: 98 · 论文数: 446
查看更多