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C

Christian Speck

imperial college london

33H指数
74论文数
4.2K被引数
收录论文 37
发表时间
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Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation
errNature Communications
IF15.7
err2026-08-14
err0
errOAAI
errYasunori Noguchi; Almutasem Saleh; Sarah Schneider; Marina E. Ivanova; Zhuo Angel Chen; Lepakshi Ranjha; Ricardo Aramayo; Silvia Tognetti; Sarah V. Faull; Juri Rappsilber; Christian Speck
err分享
err收藏
Mechanisms of MCM2–7 helicase activation and initial DNA melting at near base-pair resolutionMCM2–7解旋酶激活机制及近碱基对分辨率的初始DNA解旋
errNature Communications
IF15.7
err2026-07-23
err0
errOAAI
errChristopher Weekes; Lia Willerding; Sanjay P. Khadayate; Korbinian Liebl; Audrey Mossler; Alex Montoya; Vanessa Rauthe; Mohammad M. Karimi; Martin Zacharias; Helle D. Ulrich; Christian Speck; L. Maximilian Reuter
err分享
err收藏
High-Throughput Proteomics Sample Preparation Using a 96-Channel Pipettor and Magnetic Pin Device使用96通道移液器和磁力针装置的高通量蛋白质组学样品制备
errJournal of Proteome Research
IF3.6
err2026-02-01
err0
PREAI
errRoumelioti, Georgia; Montoya, Alex; Fisher, Gemma L. M.; Navarro, Eneko Pascual; Woods, Angela; Bennett, Jane; Navaratnam, Naveenan; Gonzalez-Carvajal, Oliver; Birch, Jodie; Pyman, Elizabeth; Yu, Sijia; Gruevska, Aleksandra; Vuillemenot, Luc-Alban; Lushchak, Oleh; Hall, Zoe; Barr, Alexis R.; Speck, Christian; Vernia, Santiago; Scott, William R.; Gil, Jesus; Aragon, Luis; Fets, Louise; Carling, David; Shliaha, Pavel V.
err分享
err收藏
Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactionsGeminin通过空间位阻阻断CDT1-MCM2相互作用来抑制DNA复制许可。
errNature Communications
IF15.7
err2025-12-09
err0
errOAAI
errJoshua Tomkins; Lucy V. Edwardes; Sarah V. Faull; Matthew Peach; Peter J. Gillespie; Vera Leber; Anna Schmidt; Halil Bounoua; Nicholas Sim; Rosa Camarillo; J. Julian Blow; Alexis R. Barr; Anna Barnard; Christian Speck
err分享
err收藏
Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing紧凑起源及其寻找方法：ORC关于全基因组许可的指南
errBIOESSAYS
IF2.7
err2025-05-19
err0
errOAAI
errSpeck, Christian; Reuter, Luitpold Maximilian
err分享
err收藏
MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing
errNATURE COMMUNICATIONS
IF15.7
err2024-08-24
err1
errOAAI
errReuter, L. Maximilian; Khadayate, Sanjay P.; Mossler, Audrey; Liebl, Korbinian; Faull, Sarah V.; Karimi, Mohammad M.; Speck, Christian
err分享
err收藏
Pre-RNA splicing in metabolic homeostasis and liver disease
errTRENDS IN ENDOCRINOLOGY AND METABOLISM
IF12.6
err2023-12-01
err5
errOAAI
errJobbins, Andrew M.; Yu, Sijia; Paterson, Helen A. B.; Maude, Hannah; Kefala-Stavridi, Antonia; Speck, Christian; Cebola, Ines; Vernia, Santiago
err分享
err收藏
The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
errNATURE COMMUNICATIONS
IF15.7
err2022-05-25
err23
errOAAI
errSaleh, Almutasem; Noguchi, Yasunori; Aramayo, Ricardo; Ivanova, Marina E.; Stevens, Kathryn M.; Montoya, Alex; Sunidhi, S.; Carranza, Nicolas Lopez; Skwark, Marcin J.; Speck, Christian
err分享
err收藏
The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
errNATURE COMMUNICATIONS
IF15.7
err2021-06-23
err28
errOAAI
errFeng, Xiang; Noguchi, Yasunori; Barbon, Marta; Stillman, Bruce; Speck, Christian; Li, Huilin
err分享
err收藏
Evolution of DNA replication origin specification and gene silencing mechanisms
errNATURE COMMUNICATIONS
IF15.7
err2020-10-14
err23
errOAAI
errHu, Y.; Tareen, A.; Sheu, Y-J.; Ireland, W. T.; Speck, C.; Li, H.; Joshua-Tor, L.; Kinney, J. B.; Stillman, B.
err分享
err收藏
Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6ORC-Cdc6将解旋酶加载到复制起点DNA上的结构机制
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2020-07-15
err38
errOAAI
errYuan, Zuanning; Schneider, Sarah; Dodd, Thomas; Riera, Alberto; Bai, Lin; Yan, Chunli; Magdalou, Indiana; Ivanov, Ivaylo; Stillman, Bruce; Li, Huilin; Speck, Christian
err分享
err收藏
Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3
errMOLECULAR BIOLOGY AND EVOLUTION
IF5.3
err2020-03-12
err2
errOAAI
errRoman-Trufero, Monica; Ito, Constance M.; Pedebos, Conrado; Magdalou, Indiana; Wang, Yi-Fang; Karimi, Mohammad M.; Moyon, Benjamin; Webster, Zoe; di Gregorio, Aida; Azuara, Veronique; Khalid, Syma; Speck, Christian; Rodriguez, Tristan; Dillon, Niall
err分享
err收藏
An integrated workflow for crosslinking mass spectrometry
errMOLECULAR SYSTEMS BIOLOGY
IF7.7
err2019-09-20
err115
errOAAI
errMendes, Marta L.; Fischer, Lutz; Chen, Zhuo A.; Barbon, Marta; O'Reilly, Francis J.; Giese, Sven H.; Bohlke-Schneider, Michael; Belsom, Adam; Dau, Therese; Combe, Colin W.; Graham, Martin; Eisele, Markus R.; Baumeister, Wolfgang; Speck, Christian; Rappsilber, Juri
err分享
err收藏
Chromosomal Sil system contributes to silver resistance in E-coli ATCC 8739
errBIOMETALS
IF3.6
err2018-10-04
err15
PREAI
errBlanco Massani, Mariana; Klumpp, Jochen; Widmer, Madeleine; Speck, Christian; Nisple, Marc; Lehmann, Rainer; Schuppler, Markus
err分享
err收藏
Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion modelDNA上Mcm2-7双六聚体的cryo-em结构表明滞后链DNA挤出模型
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2017-10-25
err75
errOAAI
errNoguchi, Yasunori; Yuan, Zuanning; Bai, Lin; Schneider, Sarah; Zhao, Gongpu; Stillman, Bruce; Speck, Christian; Li, Huilin
err分享
err收藏
Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2017-02-13
err132
errOAAI
errYuan, Zuanning; Riera, Alberto; Bai, Lin; Sun, Jingchuan; Nandi, Saikat; Spanos, Christos; Chen, Zhuo Angel; Barbon, Marta; Rappsilber, Juri; Stillman, Bruce; Speck, Christian; Li, Huilin
err分享
err收藏
Exceeding the limits-Cdc45 overexpression turns bad超过limits-Cdc45的过度表达变得糟糕
errCELL CYCLE
IF3.4
err2016-06-01
err4
errOAAI
errSpeck, Christian
err分享
err收藏
Replicating repetitive DNA
errNATURE CELL BIOLOGY
IF19.1
err2016-05-27
err3
PREAI
errTognetti, Silvia; Speck, Christian
err分享
err收藏
A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase
errNUCLEIC ACIDS RESEARCH
IF13.1
err2015-09-03
err11
errOAAI
errHerrera, M. Carmen; Tognetti, Silvia; Riera, Alberto; Zech, Juergen; Clarke, Pippa; Fernandez-Cid, Alejandra; Speck, Christian
err分享
err收藏
Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication
errELIFE
IF0
err2015-08-25
err29
errOAAI
errChang, FuJung; Riera, Alberto; Evrin, Cecile; Sun, Jingchuan; Li, Huilin; Speck, Christian; Weinreich, Michael
err分享
err收藏

研究方向

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合作学者
合作期刊
W
Wolfgang Baumeister
H 指数: 125 · 论文数: 729
B
Bruce Stillman
H 指数: 107 · 论文数: 374
D
David Carling
H 指数: 95 · 论文数: 337
J
Juri Rappsilber
H 指数: 94 · 论文数: 494
H
Huilin Li
H 指数: 79 · 论文数: 517
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