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H

Hernando Sosa

Albert Einstein College of Medicine

H指数:26

被引数:2,397

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Kinesins as dynamic drug targets: structural insights and emerging therapeutic strategies

动力蛋白作为动态药物靶点：结构见解与新兴治疗策略

Trends in Biochemical Sciences

IF11

2026-09-220

OAAI

Pathogenic KIF1A R350 mutations disrupt a conserved and conformation-dependent kinesin-tubulin salt bridge

致病性KIF1A R350突变破坏了一个保守的、构象依赖性的驱动蛋白-微管蛋白盐桥

Nature Communications

IF15.7

2026-03-310

OAAI

Cryo-EM unveils kinesin KIF1A's processivity mechanism and the impact of its pathogenic variant P305L

NATURE COMMUNICATIONS

IF15.7

2024-07-022

OAAI

New insights into the mechanochemical coupling mechanism of kinesin-microtubule complexes from their high-resolution structures

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2023-08-105

OAAI

Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape

NATURE COMMUNICATIONS

IF15.7

2022-07-2014

OAAI

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

NATURE COMMUNICATIONS

IF15.7

2021-06-1516

OAAI

Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin

CURRENT BIOLOGY

IF7.5

2019-07-0139

OAAI

Cryo-EM Reveals the Chemo-Mechanical Coupling of the Oncogenic Kinesin-3 KIF14

BIOPHYSICAL JOURNAL

IF3.1

2019-02-010

OAAI

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s (vol 9, 1662, 2018)

NATURE COMMUNICATIONS

IF15.7

2018-07-111

OAAI

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s

NATURE COMMUNICATIONS

IF15.7

2018-04-2550

OAAI

Exploring the Mechanism of Microtubule Depolymerization by the Kinesin 13 KLP10A and it's Phosphoregulation

BIOPHYSICAL JOURNAL

IF3.1

2017-02-010

OAAI

Distinct Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule

BIOPHYSICAL JOURNAL

IF3.1

2016-04-018

OAAI

Exploring the Mechanisms of a Phosphorylation Induced Inhibition of Microtubule Depolymerization in the Kinesin 13 KLP10A

BIOPHYSICAL JOURNAL

IF3.1

2016-02-010

OAAI

Structural and Functional Adaptations in Kinesin Motors

BIOPHYSICAL JOURNAL

IF3.1

2016-02-010

OAAI

Human fidgetin is a microtubule severing enzyme and minus-end depolymerase that regulates mitosis

IF3.4

2014-10-2883

OAAI

Structural Model for Tubulin Recognition and Deformation by Kinesin-13 Microtubule Depolymerases

IF6.9

2013-03-0163

OA

Mechanism of Kinesin-13 Binding to Microtubules as Revealed by Single Molecule Fluorescence Polarization Microscopy

BIOPHYSICAL JOURNAL

IF3.1

2012-01-010

OAAI

Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration

NATURE CELL BIOLOGY

IF19.1

2011-03-06113

OAAI

The Drosophila Kinesin-13, KLP59D, Impacts Pacman- and Flux-based Chromosome Movement

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2009-11-1535

OAAI

Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A

JOURNAL OF CELL BIOLOGY

IF6.4

2009-08-1732

OAAI