Ian J. Reynolds - Publications, H-index & Citations

Ian J. Reynolds

merck & company

69H指数

200论文数

1.7W被引数

收录论文 47

发表时间

Lessons from the Tim Greenamyre model Tim Greenamyre模型的启示

Neurobiology of Disease

IF5.6

2025-06-09

OAAI

Laurie H. Sanders; Nancy Blechman; Sarah Berman; Erwan Bezard; Fabio Blandini; Jason Cannon; Mark Cookson; Briana De Miranda; Roberto Di Maio; Robert Drolet; Jim Greene; Jessica Kappel; Mark Kaufmann; Matthew Keeney; Arthur S. Levine; Abby Olsen; Teddy Pettus; Sean Pintchovski; Ian Reynolds; Emily Rocha; Pier Mastroberardino

Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation (vol 24, pg 2499, 2004)

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Glading, A; Bodnar, RJ; Reynolds, IJ; Shiraha, H; Satish, L; Potter, DA; Blair, HC; Wells, A

Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

290

OAAI

Glading, A; Bodnar, RJ; Reynolds, IJ; Shiraha, H; Satish, L; Potter, DA; Blair, HC; Wells, A

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

BIOMEDICINES

IF3.9

2021-04-29

OAAI

Liu, Hilary Y.; Gale, Jenna R.; Reynolds, Ian J.; Weiss, John H.; Aizenman, Elias

The Redox Biology of Excitotoxic Processes: The NMDA Receptor, TOPA Quinone, and the Oxidative Liberation of Intracellular Zinc

FRONTIERS IN NEUROSCIENCE

IF3.2

2020-07-24

OAAI

Aizenman, Elias; Loring, Ralph H.; Reynolds, Ian J.; Rosenberg, Paul A.

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques

MOVEMENT DISORDERS

IF7.6

2018-12-21

PREAI

Johnston, Tom H.; Geva, Michal; Steiner, Lilach; Orbach, Aric; Papapetropoulos, Spyros; Savola, Juha-Matti; Reynolds, Ian J.; Ravenscroft, Paula; Hill, Michael; Fox, Susan H.; Brotchie, Jonathan M.; Laufer, Ralph; Hayden, Michael R.

Drug repurposing from the perspective of pharmaceutical companies

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2017-05-18

267

OAAI

Cha, Y.; Erez, T.; Reynolds, I. J.; Kumar, D.; Ross, J.; Koytiger, G.; Kusko, R.; Zeskind, B.; Risso, S.; Kagan, E.; Papapetropoulos, S.; Grossman, I.; Laifenfeld, D.

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

JOURNAL OF CELL BIOLOGY

IF6.4

2017-03-02

134

OAAI

Divakaruni, Ajit S.; Wallace, Martina; Buren, Caodu; Martyniuk, Kelly; Andreyev, Alexander Y.; Li, Edward; Fields, Jerel A.; Cordes, Thekla; Reynolds, Ian J.; Bloodgood, Brenda L.; Raymond, Lynn A.; Metallo, Christian M.; Murphy, Anne N.

Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2014-09-01

OAAI

Kalinichev, Mikhail; Le Poul, Emmanuel; Bolea, Christelle; Girard, Francoise; Campo, Brice; Fonsi, Massimiliano; Royer-Urios, Isabelle; Browne, Susan E.; Uslaner, Jason M.; Davis, Matthew J.; Raber, Jacob; Duvoisin, Robert; Bate, Simon T.; Reynolds, Ian J.; Poli, Sonia; Celanire, Sylvain

Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice 选择性腺苷A2A受体拮抗剂SCH 412348对MitoPark小鼠帕金森病表型的影响

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2014-04-01

PREAI

Smith, Karen M.; Browne, Susan E.; Jayaraman, Srinivasan; Bleickardt, Carina J.; Hodge, Lisa M.; Lis, Edward; Yao, Leon; Rittle, Sunday L.; Innocent, Nathalie; Mullins, Deborra E.; Boykow, George; Reynolds, Ian J.; Hill, David; Parker, Eric M.; Hodgson, Robert A.

A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2012-10-01

PREAI

Le Poul, Emmanuel; Bolea, Christelle; Girard, Francoise; Poli, Sonia; Charvin, Delphine; Campo, Brice; Bortoli, Julien; Bessif, Abdhelak; Luo, Bin; Koser, Amy Jo; Hodge, Lisa M.; Smith, Karen M.; DiLella, Anthony G.; Liverton, Nigel; Hess, Fred; Browne, Susan E.; Reynolds, Ian J.

Tissue and corneal donation and transplantation in the UK

BRITISH JOURNAL OF ANAESTHESIA

IF9.2

2012-01-01

OAAI

Gaum, L.; Reynolds, I.; Jones, M. N. A.; Clarkson, A. J.; Gillan, H. L.; Kaye, S. B.

Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity

HUMAN MOLECULAR GENETICS

IF3.2

2011-10-04

OAAI

Nikonova, Elena V.; Xiong, Yulan; Tanis, Keith Q.; Dawson, Valina L.; Vogel, Robert L.; Finney, Eva M.; Stone, David J.; Reynolds, Ian J.; Kern, Jonathan T.; Dawson, Ted M.

High Throughput Monitoring of Amyloid-β42 Assembly into Soluble Oligomers Achieved by Sensitive Conformation State-Dependent Immunoassays

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2011-08-05

PREAI

Zhao, Wei-Qin; Toolan, Dawn; Hepler, Robert W.; Wolfe, Abigail L.; Yu, Yuanjiang; Price, Eric; Uebele, Victor N.; Schachter, Joel B.; Reynolds, Ian J.; Renger, John J.; McCampbell, Alexander; Ray, William J.

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-02-01

175

OAAI

Chen, Hung-Kai; Ji, Zhong-Sheng; Dodson, Sara E.; Miranda, Rene D.; Rosenblum, Charles I.; Reynolds, Ian J.; Freedman, Stephen B.; Weisgraber, Karl H.; Huang, Yadong; Mahley, Robert W.

Selective spatial learning impairments and attention deficits precede a frank motor phenotype in a mouse model of Parkinson's disease

PARKINSONISM & RELATED DISORDERS

IF3.4

2009-12-01

PREAI

Browne, S. E.; Dillon, G.; Ferguson, M.; Reynolds, I. J.; Dodart, J. -C.

Trifluoperazine and dibucaine-induced inhibition of glutamate-induced mitochondrial depolarization in rat cultured forebrain neurones

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2009-02-05

OAAI

Hoyt, KR; Sharma, TA; Reynolds, IJ

Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-09-26

PREAI

Yang, Zhi-Qiang; Barrow, James C.; Shipe, William D.; Schlegel, Kelly-Ann S.; Shu, Youheng; Yang, F. Vivien; Lindsley, Craig W.; Rittle, Kenneth E.; Bock, Mark G.; Hartman, George D.; Uebele, Victor N.; Nuss, Cindy E.; Fox, Steve V.; Kraus, Richard L.; Doran, Scott M.; Connolly, Thomas M.; Tang, Cuyue; Ballard, Jeanine E.; Kuo, Yuhsin; Adarayan, Emily D.; Prueksaritanont, Thomayant; Zrada, Matthew M.; Marino, Michael J.; Graufelds, Valerie Kuzmick; DiLella, Anthony G.; Reynolds, Ian J.; Vargas, Hugo M.; Bunting, Patricia B.; Woltmann, Richard F.; Magee, Michael M.; Koblan, Kenneth S.; Renger, John J.

Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2 在缺乏核苷酸受体P2Y2的小鼠中，热伤害感受和TRPV1功能减弱

PAIN

IF5.5

2008-09-15

OAAI

Malin, Sacha A.; Davis, Brian M.; Koerber, H. Richard; Reynolds, Ian J.; Albers, Kathryrn M.; Molliver, Derek C.

Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species production

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-02-01

OAAI

Gusdon, Aaron M.; Votyakova, Tatyana V.; Reynolds, Ian J.; Mathews, Clayton E.

研究方向