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T

Toru Komatsu

The University of Tokyo

49H指数
203论文数
8.0K被引数
收录论文 96
发表时间
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Synthesis Based on Covalent Capture and Release Enables Purification-free Fluorogenic Probe Libraries for Single-Molecule Protease Activity Profiling基于共价捕获和释放的合成方法实现了无需纯化的荧光探针库，用于单分子蛋白酶活性分析
errACS Central Science
IF10.4
err2026-06-29
err0
errOAAI
errMayano Minoda; Tadahaya Mizuno; Takumi Iwasaka; Hiroyuki Kusuhara; Yu Kagami; Shingo Sakamoto; Norimichi Nagano; Chiaki Hori; Kazufumi Honda; Yasuteru Urano; Toru Komatsu
err分享
err收藏
Solid-Phase Synthesis of ProTide Fluorogenic Probes Enables Systematic Profiling of Carboxypeptidase Activity固相合成ProTide荧光探针实现羧肽酶活性的系统分析
errJournal of the American Chemical Society
IF15.6
err2026-05-19
err0
PREAI
errToru Komatsu; Mayano Minoda; Takako Uchida; Momoka Hata; Shunsuke Kanai; Hideto Hiraide; Yu Kagami; Kazufumi Honda; Yasuteru Urano
err分享
err收藏
Development of Single-Molecule Enzyme Activity Assay for Serine Hydrolases Using Activity-Based Protein Labeling Probes利用基于活性的蛋白质标记探针开发丝氨酸水解酶的单分子酶活性测定方法
errSMALL METHODS
IF9.1
err2025-09-01
err0
errOAAI
errIshii, Seiya; Minoda, Mayano; Mizuno, Tadahaya; Iwasaka, Takumi; Kusuhara, Hiroyuki; Honda, Kazufumi; Urano, Yasuteru; Komatsu, Toru
err分享
err收藏
Mechanisms of histopathologic vascular damage caused by pancreatic juice leakage: Implications for preventing hemorrhagic complications胰腺汁液泄漏所致组织病理学血管损伤的机制：对预防出血性并发症的启示
errSurgery
IF2.7
err2025-08-05
err0
errOAAI
errYusuke Seki; Takeaki Ishizawa; Kento Mitsuhashi; Natsuko F. Inagaki; Kazuhiro Mori; Genki Watanabe; Toru Komatsu; Yasuteru Urano; Hiroyuki Abe; Tetsuo Ushiku; Taichi Ito; Kiyoshi Hasegawa
err分享
err收藏
Single-Molecule Enzyme Activity Analysis for Illuminating Pathological Proteoforms单分子酶活性分析以阐明病理性蛋白质变体
errACS Central Science
IF10.4
err2025-06-17
err0
errOAAI
errToru Komatsu; Tadahaya Mizuno
err分享
err收藏
Application of Intramolecular O-to-N Phosphoryl Transfer Reaction to Design Fluorogenic Probes to Detect Activities of Enzymes That Metabolize Short Peptides and Acylamino Acids应用分子内O-到-N磷酸基转移反应设计荧光探针以检测代谢短肽和酰氨基酸的酶活性
errACS SENSORS
IF9.1
err2025-02-04
err0
PREAI
errSawayama, R; Minoda, M; Kojima, H; Okabe, T; Isayama, Y; Kato, K; Nishimasu, H; Urano, Y; Komatsu, T
err分享
err收藏
Identification of a pancreatic juice-specific fluorescent probe through 411 probes activated by aminopeptidases/ proteases or phosphatases/phosphodiesterases通过411种由氨肽酶/蛋白酶或磷酸酶/磷酸二酯酶激活的探针，鉴定一种胰腺汁特异性荧光探针
errHPB
IF2.4
err2025-02-01
err0
PREAI
errSeki, Yusuke; Ishizawa, Takeaki; Watanabe, Genki; Komatsu, Toru; Nanjo, Aika; Urano, Yasuteru; Kawaguchi, Mitsuyasu; Nakagawa, Hidehiko
err分享
err收藏
Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia
errRSC CHEMICAL BIOLOGY
IF3.1
err2025-01-01
err0
errOAAI
errKasai, Takafumi; Fujita, Kyohhei; Komatsu, Toru; Ueno, Tasuku; Kojima, Ryosuke; Hanaoka, Kenjiro; Urano, Yasuteru
err分享
err收藏
γ-Secretase Cleaves Bifunctional Fatty Acid-Conjugated Small Molecules with Amide Bonds in Mammalian Cells
errACS CHEMICAL BIOLOGY
IF3.8
err2024-11-20
err1
PREAI
errTahara, Kai; Nakamura, Akinobu; Wang, Xiaotong; Mitamura, Keishi; Ichihashi, Yuki; Kano, Keiko; Mishiro-Sato, Emi; Aoki, Kazuhiro; Urano, Yasuteru; Komatsu, Toru; Tsukiji, Shinya
err分享
err收藏
A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)
errSCIENCE ADVANCES
IF12.5
err2024-02-16
err7
errOAAI
errHanaoka, Kenjiro; Ikeno, Takayuki; Iwaki, Shimpei; Deguchi, Sayaka; Takayama, Kazuo; Mizuguchi, Hiroyuki; Tao, Fumiya; Kojima, Nobuhiko; Ohno, Hisashi; Sasaki, Eita; Komatsu, Toru; Ueno, Tasuku; Maeda, Kazuya; Kusuhara, Hiroyuki; Urano, Yasuteru
err分享
err收藏
Identification of activity-based biomarkers for early-stage pancreatic tumors in blood using single-molecule enzyme activity screening
errCELL REPORTS METHODS
IF4.5
err2024-01-01
err3
errOAAI
errSakamoto, Shingo; Hiraide, Hideto; Minoda, Mayano; Iwakura, Nozomi; Suzuki, Misa; Ando, Jun; Takahashi, Chiharu; Takahashi, Ikuko; Murai, Kazue; Kagami, Yu; Mizuno, Tadahaya; Koike, Tohru; Nara, Satoshi; Morizane, Chigusa; Hijioka, Susumu; Kashiro, Ayumi; Honda, Kazufumi; Watanabe, Rikiya; Urano, Yasuteru; Komatsu, Toru
err分享
err收藏
Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition在微型设备中基于硫酯的偶联荧光测定，用于检测具有特定底物识别功能的酯酶的单分子酶活性
errADVANCED SCIENCE
IF14.1
err2023-12-22
err1
errOAAI
errUkegawa, Tatsuya; Komatsu, Toru; Minoda, Mayano; Matsumoto, Takuya; Iwasaka, Takumi; Mizuno, Tadahaya; Tachibana, Ryo; Sakamoto, Shingo; Hanaoka, Kenjiro; Kusuhara, Hiroyuki; Honda, Kazufumi; Watanabe, Rikiya; Urano, Yasuteru
err分享
err收藏
Modular Design Platform for Activatable Fluorescence Probes Targeting Carboxypeptidases Based on ProTide Chemistry
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-12-18
err4
PREAI
errKuriki, Yugo; Sogawa, Mari; Komatsu, Toru; Kawatani, Minoru; Fujioka, Hiroyoshi; Fujita, Kyohhei; Ueno, Tasuku; Hanaoka, Kenjiro; Kojima, Ryosuke; Hino, Rumi; Ueo, Hiroki; Ueo, Hiroaki; Kamiya, Mako; Urano, Yasuteru
err分享
err收藏
Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation
errSCIENTIFIC REPORTS
IF3.9
err2023-09-30
err4
errOAAI
errEchizen, Honami; Hanaoka, Kenjiro; Shimamoto, Kazuhito; Hibi, Ryota; Toma-Fukai, Sachiko; Ohno, Hisashi; Sasaki, Eita; Komatsu, Toru; Ueno, Tasuku; Tsuchiya, Yukihiro; Watanabe, Yasuo; Otsuka, Takao; Saito, Hiroaki; Nagatoishi, Satoru; Tsumoto, Kouhei; Kojima, Hirotatsu; Okabe, Takayoshi; Shimizu, Toshiyuki; Urano, Yasuteru
err分享
err收藏
A protease activity-based machine-learning approach as a complementary tool for conventional diagnosis of diarrhea-predominant irritable bowel syndrome
errFRONTIERS IN MICROBIOLOGY
IF4.5
err2023-07-07
err0
errOAAI
errTanaka, Kazuki; Tanigawa, Naoki; Song, Isaiah; Komatsu, Toru; Kuriki, Yugo; Tanaka, Yukari; Fukudo, Shin; Urano, Yasuteru; Fukuda, Shinji
err分享
err收藏
Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells
errCOMMUNICATIONS CHEMISTRY
IF6.2
err2023-04-13
err3
errOAAI
errYanagi, Kouichi; Komatsu, Toru; Fujikawa, Yuuta; Kojima, Hirotatsu; Okabe, Takayoshi; Nagano, Tetsuo; Ueno, Tasuku; Hanaoka, Kenjiro; Urano, Yasuteru
err分享
err收藏
Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis
errCHEMICAL SCIENCE
IF7.4
err2023-01-01
err4
errOAAI
errNagano, Norimichi; Ichihashi, Yuki; Komatsu, Toru; Matsuzaki, Hiroyuki; Hata, Keisuke; Watanabe, Toshiaki; Misawa, Yoshihiro; Suzuki, Misa; Sakamoto, Shingo; Kagami, Yu; Kashiro, Ayumi; Takeuchi, Keiko; Kanemitsu, Yukihide; Ochiai, Hiroki; Watanabe, Rikiya; Honda, Kazufumi; Urano, Yasuteru
err分享
err收藏
General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2022-10-03
err72
PREAI
errHanaoka, Kenjiro; Iwaki, Shimpei; Yagi, Kiyoshi; Myochin, Takuya; Ikeno, Takayuki; Ohno, Hisashi; Sasaki, Eita; Komatsu, Toru; Ueno, Tasuku; Uchigashima, Motokazu; Mikuni, Takayasu; Tainaka, Kazuki; Tahara, Shinya; Takeuchi, Satoshi; Tahara, Tahei; Uchiyama, Masanobu; Nagano, Tetsuo; Urano, Yasuteru
err分享
err收藏
Rapid imaging of lung cancer using a red fluorescent probe to detect dipeptidyl peptidase 4 and puromycin-sensitive aminopeptidase activities
errSCIENTIFIC REPORTS
IF3.9
err2022-06-01
err7
errOAAI
errKawashima, Shun; Yoshida, Daisuke; Yoshioka, Takafusa; Ogasawara, Akira; Fujita, Kyohhei; Yanagiya, Masahiro; Nagano, Masaaki; Konoeda, Chihiro; Hino, Haruaki; Kitano, Kentaro; Sato, Masaaki; Hino, Rumi; Kojima, Ryosuke; Komatsu, Toru; Kamiya, Mako; Urano, Yasuteru; Nakajima, Jun
err分享
err收藏
Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity
errRSC CHEMICAL BIOLOGY
IF3.1
err2022-01-01
err8
errOAAI
errHoshino, Yuki; Hanaoka, Kenjiro; Sakamoto, Kei; Yasunaga, Masahiro; Kojima, Takashi; Kotani, Daisuke; Nomoto, Ayumu; Sasaki, Eita; Komatsu, Toru; Ueno, Tasuku; Takamaru, Hiroyuki; Saito, Yutaka; Seto, Yasuyuki; Urano, Yasuteru
err分享
err收藏

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