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Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies Zhai, Shiyang; Kemkes, Marie; Kponomaizoun, Cindy-Esther; Gerhartz, Jan; Feller, Felix; Tu, Jia-Wey; Pienkowska, Dominika Ewa; Schliehe-Diecks, Julian; Dressel, Ina; Gutschow, Michael; Nowak, Radoslaw P.; Steinebach, Christian; Bhatia, Sanil; Hansen, Finn K. 分享 收藏
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A Facile Protocol for C(sp2)-C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands 面向功能化E3连接酶配体的C(sp2)-C(sp3) 键形成反应的简便方案 Maksutova, Anita; Geiger, Thomas M.; Cianni, Lorenzo; Pienkowska, Dominika E.; Gerhartz, Jan; Read, Lina; Bricelj, Alesa; Herrmann, Alexander; Nelles, Maurice Leon; Ng, Yuen Lam Dora; Hartmann, Marcus D.; Kronke, Jan; Sosic, Izidor; Nowak, Radoslaw P.; Gutschow, Michael; Steinebach, Christian 分享 收藏
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Salamandamide Lipodipeptides Are Biosynthetic Intermediate Shunt Products of the Nonamodular Nonribosomal Peptide Assembly Lines of the Viscosin Family Bhattarai, Keshab; Majer, Thomas; Haussmann, Manuela; Schollmeyer, Dieter; Kramer, Markus; Oni, Feyisara Eyiwumi; Hoefte, Monica; Voget, Rabea; Guetschow, Michael; Ruetalo, Natalia; Schindler, Michael; Straetener, Jan; Wannenwetsch, Tatjana; Broetz-Oesterhelt, Heike; Karongo, Ryan; Masberg, Benedikt; Laemmerhofer, Michael; Hennessy, Rosanna Catherine; Muletz-Wolz, Carly R.; Gross, Harald 分享 收藏
Contilisant-Belinostat Hybrids: Polyfunctionalized Indole Derivatives as Multineurotarget Drugs for the Potential Treatment of Alzheimer's Disease Contilisant-Belinostat 杂合体：多官能化吲哚衍生物作为多神经靶点药物用于阿尔茨海默病潜在治疗 Schäker-Hübner, L; Toledano-Pinedo, M; Eimermacher, S; Krasniqi, V; Porro-Perez, A; Tan, K; Horn, G; Stegen, P; Elsinghorst, PW; Wille, T; Pietsch, M; Gütschow, M; Marco-Contelles, J; Hansen, FK 分享 收藏
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Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity Oneto, Angelo; Al Hamwi, Ghazl; Schaekel, Laura; Krueger, Nadine; Sylvester, Katharina; Petry, Marvin; Abu Shamleh, Rasha; Pillaiyar, Thanigaimalai; Claff, Tobias; Schiedel, Anke C.; Straeter, Norbert; Guetschow, Michael; Mueller, Christa E. 分享 收藏
Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs BCL-2靶向PROTACs的设计、合成与评价 Bricelj, Alesa; Ng, Yuen Lam Dora; Gobec, Martina; Kuchta, Robert; Hu, Wanyi; Javornik, Spela; Rozic, Miha; Guetschow, Michael; Zheng, Guangrong; Kroenke, Jan; Steinebach, Christian; Sosic, Izidor 分享 收藏
USP7 IS AN INTERACTION PARTNER OF EZHIP AND POTENTIAL DRUGGABLE TARGET IN PFA EPENDYMOMAS Jenseit, Anne; Camgoez, Aylin; Mauermann, Monika; Mack, Norman; Schwalm, Benjamin; Mohr, Jacqueline; Wittenburg, Sophie; Steinebach, Christian; Guetschow, Michael; Peterziel, Heike; Friedenauer, Aileen; Jaunecker, Carola; Loetsch-Gojo, Daniela; Oehme, Ina; Pfister, Stefan M.; Kool, Marcel 分享 收藏
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs Breidenbach, Julian; Voget, Rabea; Si, Yaoyao; Hingst, Alexandra; Claff, Tobias; Sylvester, Katharina; Wolf, Valentina; Krasniqi, Vesa; Useini, Abibe; Straeter, Norbert; Ogura, Yukino; Kawaguchi, Atsushi; Mueller, Christa E.; Guetschow, Michael 分享 收藏
Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead Yamauchi, Yuki; Konno, Sho; Omura, Noriko; Yoshioka, Narumi; Hingst, Alexandra; Guetschow, Michael; Mueller, Christa E.; Taguchi, Akihiro; Taniguchi, Atsuhiko; Kawaguchi, Atsushi; Hayashi, Yoshio 分享 收藏
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties Pachon-Angona, Irene; Bernard, Paul J.; Simakov, Alexey; Maj, Maciej; Jozwiak, Krzysztof; Novotna, Anna; Lemke, Carina; Guetschow, Michael; Martin, Helene; Oset-Gasque, Maria-Jesus; Contelles, Jose-Marco; Ismaili, Lhassane 分享 收藏
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs Steinebach, Christian; Bricelj, Alesa; Murgai, Arunima; Sosic, Izidor; Bischof, Luca; Ng, Yuen Lam Dora; Heim, Christopher; Maiwald, Samuel; Proj, Matic; Voget, Rabea; Feller, Felix; Kosmrlj, Janez; Sapozhnikova, Valeriia; Schmidt, Annika; Zuleeg, Maximilian Rudolf; Lemnitzer, Patricia; Mertins, Philipp; Hansen, Finn K.; Guetschow, Michael; Kroenke, Jan; Hartmann, Marcus D. 分享 收藏
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers Vu, Lan Phuong; Diehl, Claudia J.; Casement, Ryan; Bond, Adam G.; Steinebach, Christian; Strasek, Nika; Bricelj, Alesa; Perdih, Andrej; Schnakenburg, Gregor; Sosic, Izidor; Ciulli, Alessio; Guetschow, Michael 分享 收藏
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins Ng, Yuen Lam Dora; Bricelj, Alesa; Jansen, Jacqueline A.; Murgai, Arunima; Peter, Kirsten; Donovan, Katherine A.; Guetschow, Michael; Kroenke, Jan; Steinebach, Christian; Sosic, Izidor 分享 收藏
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