Aaron Havas - Publications, H-index & Citations

Aaron Havas

Sanford Burnham Prebys Medical Discovery Institute

13H指数

42论文数

1.2K被引数

收录论文 21

发表时间

Inhibiting cyclin D1–CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline 抑制cyclin D1–CDK6可抑制衰老相关炎症基因表达和年龄相关功能下降

Nature Aging

IF19.4

2026-08-20

PREAI

Adarsh Rajesh; Aaron P. Havas; Rouven Arnold; Kathryn Lande; Xue Lei; Kelly Yichen Li; Armin Gandhi; Ana Catarina Franco; Seung-Hwa Woo; Anthony B. Lagnado; Angela Liou; K. Garrett Evensen; Linshan Laux; Maggie Klaers; Jake Kircher; Amirhossein Nayeri Rad; Hiroshi Tanaka; Marcos Garcia Teneche; Michael Alcaraz; Karl N. Miller; Zoe Yao; Sviatlana Zaretski; Sainath Mamde; Qian Yang; Jessica Proulx; Andrew Davis; Laurence Haddadin; Carolina Cano Macip; Brightany Li; Nirmalya Dasgupta; Zong Ming Chua; Cedomir Stamenkovic; Gabriele Guarnaccia; Hideki Tanizawa; Charlene Miciano; Elizabeth Smoot; Allen Wang; Rebecca A. Porritt; Alessandra Sacco; Ken-ichi Noma; Jeffrey H. Albrecht; Laura J Niedernhofer; Joao F Passos; April E. Williams; Bing Ren; Kevin Y. Yip; Peter D. Adams

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells 衰老诱导的肝细胞CD44驱动与邻近T细胞功能障碍相关的IL6/STAT3信号通路

npj Aging

IF6

2026-08-13

OAAI

Armin Gandhi; Kathryn Lande; Kelly Yichen Li; Filipe A. Hoffmann; Michael LaPorte; Shirong Tan; K. Garrett Evensen; Benji Portillo; Marcos Garcia Teneche; Rouven Arnold; Adarsh Rajesh; Jessica Proulx; Shanshan Yin; Aaron Havas; Angela Liou; Allen Lee; Helene Martini; Xue Lei; Charlene Miciano; Qian Yang; Elizabeth W. Smoot; Sainath Mamde; Andrew Davis; Rebecca Porritt; Alessandra Sacco; João F. Passos; Kevin M. Tharp; Kevin Yip; Allen Wang; Bing Ren; April Williams; Susan Kaech; Peter D. Adams

Mitochondrial metabolism and epigenetic crosstalk drive SASP 线粒体代谢与表观遗传学串扰驱动SASP

Nature

IF48.5

2026-07-29

OAAI

Hélène Martini; Jodie Birch; Francisco D. M. Marques; Stella Victorelli; Anthony B. Lagnado; Nicholas Pirius; Ana Catarina Franco; Gung Lee; Yeaeun Han; Jennifer L. Rowsey; Wazim Mohammed Ismail; Amelia Mazzone; Tianna M. Espe; Taro Hitosugi; Ya Li; Alexander M. Washington; Aaron Havas; Rabi Murad; Xue Lei; Rebecca A. Porritt; Oliver D. K. Maddocks; Jair Machado Espindola-Netto; Dominik Saul; Sundeep Khosla; Diana Jurk; Enis Kostallari; Alexandre Gaspar-Maia; Peter D. Adams; João F. Passos

Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by Aging

Aging Cell

IF7.1

2026-02-07

OAAI

Aaron Havas; Adarsh Rajesh; Xue Lei; Jessica Proulx; Karl N. Miller; Adam Field; Andrew Davis; Marcos Garcia Teneche; Armin Gandhi; Jin Lee; Gen-Sheng Feng; Peter D. Adams

Author Correction: ImAge quantitates aging and rejuvenation 作者更正：ImAge定量分析衰老与返老还童

Nature Aging

IF19.4

2025-08-05

PREAI

Martin Alvarez-Kuglen; Kenta Ninomiya; Haodong Qin; Delany Rodriguez; Lorenzo Fiengo; Chen Farhy; Wei-Mien Hsu; Brian Kirk; Aaron Havas; Collin Kaufman; Gen-Sheng Feng; Amanda J. Roberts; Rozalyn M. Anderson; Manuel Serrano; Peter D. Adams; Tatyana O. Sharpee; Alexey V. Terskikh

WSTF nuclear autophagy regulates chronic but not acute inflammation WSTF核自噬调节慢性而非急性炎症

Nature

IF48.5

2025-07-02

PREAI

Yu Wang; Vinay V. Eapen; Yaosi Liang; Athanasios Kournoutis; Marc Samuel Sherman; Yanxin Xu; Angelique Onorati; Xianting Li; Xiaoting Zhou; Kathleen E. Corey; Kuo Du; Ana Maria Cabral Burkard; Chia-Kang Ho; Jing Xie; Hui Zhang; Raquel Maeso-Díaz; Xinyi Ma; Ulrike Rieprecht; Tara O’Brien; Murat Cetinbas; Lu Wang; Jihe Liu; Corey Bretz; Aaron P. Havas; Zhuo Zhou; Shannan J. Ho Sui; Srinivas Vinod Saladi; Ruslan I. Sadreyev; Peter D. Adams; Robert E. Kingston; Anna Mae Diehl; Benjamin Alman; Wolfram Goessling; Zhenyu Yue; Xiao-Fan Wang; Terje Johansen; Zhixun Dou

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells p53增强DNA修复，并抑制衰老细胞中的细胞质染色质片段和炎症。

NATURE COMMUNICATIONS

IF15.7

2025-03-05

OAAI

Miller, Karl N.; Li, Brightany; Pierce-Hoffman, Hannah R.; Patel, Shreeya; Lei, Xue; Rajesh, Adarsh; Teneche, Marcos G.; Havas, Aaron P.; Gandhi, Armin; Macip, Carolina Cano; Lyu, Jun; Victorelli, Stella G.; Woo, Seung-Hwa; Lagnado, Anthony B.; Laporta, Michael A.; Liu, Tianhui; Dasgupta, Nirmalya; Li, Sha; Davis, Andrew; Korotkov, Anatoly; Hultenius, Erik; Gao, Zichen; Altman, Yoav; Porritt, Rebecca A.; Garcia, Guillermina; Mogler, Carolin; Seluanov, Andrei; Gorbunova, Vera; Kaech, Susan M.; Tian, Xiao; Dou, Zhixun; Chen, Chongyi; Passos, Joao F.; Adams, Peter D.

Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

MOLECULAR CELL

IF16.6

2024-09-01

PREAI

Dasgupta, Nirmalya; Lei, Xue; Shi, Christina Huan; Arnold, Rouven; Teneche, Marcos G.; Miller, Karl N.; Rajesh, Adarsh; Davis, Andrew; Anschau, Valesca; Campos, Alexandre R.; Gilson, Rebecca; Havas, Aaron; Yin, Shanshan; Chua, Zong Ming; Liu, Tianhui; Proulx, Jessica; Alcaraz, Michael; Rather, Mohammed Iqbal; Baeza, Josue; Schultz, David C.; Yip, Kevin Y.; Berger, Shelley L.; Adams, Peter D.

ImAge quantitates aging and rejuvenation 影像量化衰老与rejuvenation

NATURE AGING

IF19.4

2024-08-29

PREAI

Alvarez-Kuglen, Martin; Ninomiya, Kenta; Qin, Haodong; Rodriguez, Delany; Fiengo, Lorenzo; Farhy, Chen; Hsu, Wei-Mien; Kirk, Brian; Havas, Aaron; Feng, Gen-Sheng; Roberts, Amanda J.; Anderson, Rozalyn M.; Serrano, Manuel; Adams, Peter D.; Sharpee, Tatyana O.; Terskikh, Alexey V.

METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence

NATURE COMMUNICATIONS

IF15.7

2024-06-26

OAAI

Wang, Chen; Tanizawa, Hideki; Hill, Connor; Havas, Aaron; Zhang, Qiang; Liao, Liping; Hao, Xue; Lei, Xue; Wang, Lu; Nie, Hao; Qi, Yuan; Tian, Bin; Gardini, Alessandro; Kossenkov, Andrew V.; Goldman, Aaron; Berger, Shelley L.; Noma, Ken-ichi; Adams, Peter D.; Zhang, Rugang

Investigating the effect of an aged liver microenvironment on immune surveillance and predisposition to cancer

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Gandhi, Armin Aabish; Hoffmann, Filipe Araujo; LaPorte, Michael, II; Havas, Aaron; Rajesh, Adarsh; Davis, Andrew; Teneche, Marcos G.; Proulx, Jessica; Kaech, Susan; Adams, Peter D.

TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation

NATURE AGING

IF19.4

2024-01-24

OAAI

Hao, Xue; Zhao, Bo; Towers, Martina; Liao, Liping; Monteiro, Edgar Luzete; Xu, Xin; Freeman, Christina; Peng, Hongzhuang; Tang, Hsin-Yao; Havas, Aaron; Kossenkov, Andrew V.; Berger, Shelley L.; Adams, Peter D.; Speicher, David W.; Schultz, David; Marmorstein, Ronen; Zaret, Kenneth S.; Zhang, Rugang

Upregulation of PD-L1 in Senescence and Aging PD-L1在衰老和衰老中的上调

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-02-24

OAAI

Onorati, Angelique; Havas, Aaron P.; Lin, Brian; Rajagopal, Jayaraj; Sen, Payel; Adams, Peter D.; Dou, Zhixun

TXNRD1 drives innate immune response in senescent cells to promote tumor immune surveillance and age-associated inflammation

CANCER RESEARCH

IF16.6

2023-01-15

PREAI

Hao, Xue; Zhao, Bo; Towers, Martina; Liao, Liping; Tang, Hsin Yao; Havas, Aaron; Kossenkov, Andrew V.; Berger, Shelley; Adams, Peter D.; Speicher, David W.; Zhang, Rugang

The role of aging in cancer

MOLECULAR ONCOLOGY

IF4.5

2022-09-20

OAAI

Havas, Aaron; Yin, Shanshan; Adams, P. D.

ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels

NATURE CELL BIOLOGY

IF19.1

2022-07-18

OAAI

Hao, Xue; Shiromoto, Yusuke; Sakurai, Masayuki; Towers, Martina; Zhang, Qiang; Wu, Shuai; Havas, Aaron; Wang, Lu; Berger, Shelley; Adams, Peter D.; Tian, Bin; Nishikura, Kazuko; Kossenkov, Andrew, V; Liu, Pingyu; Zhang, Rugang

DNA Methylation Clocks in Aging: Categories, Causes, and Consequences

MOLECULAR CELL

IF16.6

2018-09-01

372

OAAI

Field, Adam E.; Robertson, Neil A.; Wang, Tina; Havas, Aaron; Ideker, Trey; Adams, Peter D.

Belinostat and vincristine demonstrate mutually synergistic cytotoxicity associated with mitotic arrest and inhibition of polyploidy in a preclinical model of aggressive diffuse large B cell lymphoma

CANCER BIOLOGY & THERAPY

IF4.6

2016-10-28

OAAI

Havas, Aaron P.; Rodrigues, Kameron B.; Bhakta, Anvi; Demirjian, Joseph A.; Hahn, Seongmin; Tran, Jack; Scavello, Margarethakay; Tula-Sanchez, Ana A.; Zeng, Yi; Schmelz, Monika; Smith, Catharine L.

Combining low dose microtubule targeting agents with belinostat potentiates cytotoxic response in HDACi resistant diffuse large b-cell lymphoma

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Havas, Aaron P.; Bhakta, Anvi; Rodrigues, Kameron; Smith, Catharine L.

A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma Role of cyclin-dependent kinase inhibitors

CANCER BIOLOGY & THERAPY

IF4.6

2014-11-05

OAAI

Tula-Sanchez, Ana A.; Havas, Aaron P.; Alonge, Peter J.; Klein, Mary E.; Doctor, Samantha R.; Pinkston, William; Glinsmann-Gibson, Betty J.; Rimsza, Lisa M.; Smith, Catharine L.

研究方向