Larisa Y. Poluektova - Publications, H-index & Citations

Larisa Y. Poluektova

university of nebraska medical center

43H指数

169论文数

5.3K被引数

收录论文 73

发表时间

Combinatorial Therapy with Long-Acting Tenofovir and Tizoxanide Controls Viral Replication and Liver Inflammation in a Murine AAV-HBV Model of Chronic Hepatitis B 长效替诺福韦和替波维联合疗法控制慢性乙型肝炎小鼠AAV-HBV模型中的病毒复制和肝脏炎症

Biology-Basel

IF3.5

2026-08-14

OAAI

Mojisola O. Ogunnaike; Ashrafi Sultana; Samiksha Raut; Weimin Wang; Grace Bybee; Howard E. Gendelman; Benson J. Edagwa; Natalia A. Osna; Larisa Y. Poluektova

Alcohol suppression of IFN immunity supports HBV replication in hepatocytes

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Singh Pathania, Anup; Chava, Haritha; Bybee, Grace A.; Bhat, Sajad A.; Gendelman, Howard; Singh Poluektova, Larisa; Osna, Natalia

Sustained suppression of HBV replication by a long-acting lipophilic TFV phosphonate prodrug is not potentiated by macrophages or increased activation of anti-viral interferon-stimulated genes (ISGs)

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Osna, Natalia A.; Pathania, Anup; Raut, Samiksha S.; Bybee, Grace A.; Chava, Haritha; Ogunnaike, Mojisola O.; Wang, Weimin O.; Poluektova, Larisa Y.; Edagwa, Benson O.

A scalable ultra-long-acting tenofovir phosphonate prodrug sustains HBV suppression 一种可扩展的超长效替诺福韦磷酸盐前药可维持HBV抑制

Science Advances

IF12.5

2025-08-01

OAAI

Samiksha S. Raut; Srijanee Das; Grace Bybee; Haritha Chava; Mojisola Ogunnaike; Weimin Wang; Anup S. Pathania; Brandon W. Hanson; Nam Thai Hoang Le; Samuel M. Cohen; Howard E. Gendelman; Larisa Y. Poluektova; Benson J. Edagwa; Natalia A. Osna

Unique molecular signatures in rebound viruses from antiretroviral drug and CRISPR-treated HIV-1-infected humanized mice 抗逆转录病毒药物和CRISPR处理的HIV-1感染人源化小鼠中反弹病毒的独特分子特征

Communications Biology

IF5.1

2025-07-19

OAAI

Chen Zhang; Haotian Li; Larisa Y. Poluektova; Howard E. Gendelman; Prasanta K. Dash

Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss 淀粉样前体蛋白和早老蛋白-1基因敲入免疫缺陷小鼠表现出神经元内Aβ病变、小胶质细胞增生和广泛的神经元丢失。

ALZHEIMERS & DEMENTIA

IF11.1

2025-04-07

OAAI

Yeapuri, P; Machhi, J; Foster, EG; Kadry, R; Bhattarai, S; Lu, YM; Sil, S; Sapkota, R; Srivastava, S; Kumar, M; Ikezu, T; Poluektova, LY; Gendelman, HE; Mosley, RL

Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes 乙醇破坏了巨噬细胞与HBV感染肝细胞之间的保护性串扰

BIOMOLECULES

IF4.8

2025-01-03

OAAI

Ganesan, Murali; Pathania, Anup S.; Bybee, Grace; Kharbanda, Kusum K.; Poluektova, Larisa Y.; Osna, Natalia A.

Single-cell profiling reveals a conserved role for hypoxia-inducible factor signaling during human craniotomy infection

CELL REPORTS MEDICINE

IF10.6

2024-11-01

OAAI

Van Roy, Zachary; Kak, Gunjan; Korshoj, Lee E.; Menousek, Joseph P.; Heim, Cortney E.; Fallet, Rachel W.; Campbell, James R.; Geary, Carol R.; Liu, Bo; Gorantla, Santhi; Poluektova, Larisa Y.; Duan, Bin; Campbell, W. Scott; Thorell, William E.; Kielian, Tammy

Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice

PHARMACEUTICALS

IF4.8

2024-01-23

OAAI

Zhang, Chen; Su, Hang; Waight, Emiko; Poluektova, Larisa Y.; Gorantla, Santhi; Gendelman, Howard E.; Dash, Prasanta K.

Increased liver stiffness promotes hepatitis B progression by impairing innate immunity in CCl4-induced fibrotic HBV+ transgenic mice

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-08-03

OAAI

Bybee, Grace; Moeun, Youra; Wang, Weimin; Kharbanda, Kusum K.; Poluektova, Larisa Y.; Kidambi, Srivatsan; Osna, Natalia A.; Ganesan, Murali

Elucidating the role of extracellular vesicles in liver injury induced by HIV

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY

IF2.5

2023-07-03

OAAI

Osna, Natalia A.; Poluektova, Larisa Y.

Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations

PHARMACEUTICS

IF5.5

2023-06-27

OAAI

Curley, Paul; Hobson, James J.; Liptrott, Neill J.; Makarov, Edward; Al-khouja, Amer; Tatham, Lee; David, Christopher A. W.; Box, Helen; Neary, Megan; Sharp, Joanne; Pertinez, Henry; Meyers, David; Flexner, Charles; Freel Meyers, Caren L.; Poluektova, Larisa; Rannard, Steve; Owen, Andrew

Humanized Mice for Studies of HIV-1 Persistence and Elimination

PATHOGENS

IF3.3

2023-06-27

OAAI

Zhang, Chen; Zaman, Lubaba A.; Poluektova, Larisa Y.; Gorantla, Santhi; Gendelman, Howard E.; Dash, Prasanta K.

CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice CCR5和HIV-1的CRISPR编辑有助于在抗逆转录病毒药物抑制的病毒感染的人源化小鼠中消除病毒

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-05-01

OAAI

Dash, Prasanta K.; Chen, Chen; Kaminski, Rafal; Su, Hang; Mancuso, Pietro; Sillman, Brady; Zhang, Chen; Liao, Shuren; Sravanam, Sruthi; Liu, Hong; Waight, Emiko; Guo, Lili; Mathews, Saumi; Sariyer, Rahsan; Mosley, R. Lee; Poluektova, Larisa Y.; Caocci, Maurizio; Amini, Shohreh; Gorantla, Santhi; Burdo, Tricia H.; Edagwa, Benson; Gendelman, Howard E.; Khalili, Kamel

An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression

SCIENCE ADVANCES

IF12.5

2022-12-23

OAAI

Das, Srijanee; Wang, Weimin; Ganesan, Murali; Fonseca-Lanza, Franchesca; Cobb, Denise A.; Bybee, Grace; Sun, Yimin; Guo, Lili; Hanson, Brandon; Cohen, Samuel M.; Gendelman, Howard E.; Osna, Natalia A.; Edagwa, Benson J.; Poluektova, Larisa Y.

Animal models for studies of HIV-1 brain reservoirs

JOURNAL OF LEUKOCYTE BIOLOGY

IF3.1

2022-08-31

OAAI

Waight, Emiko; Zhang, Chen; Mathews, Saumi; Kevadiya, Bhavesh D.; Lloyd, K. C. Kent; Gendelman, Howard E.; Gorantla, Santhi; Poluektova, Larisa Y.; Dash, Prasanta K.

Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation

BIOLOGY-BASEL

IF3.5

2022-07-14

OAAI

New-Aaron, Moses; Dagur, Raghubendra Singh; Koganti, Siva Sankar; Ganesan, Murali; Wang, Weimin; Makarov, Edward; Ogunnaike, Mojisola; Kharbanda, Kusum K.; Poluektova, Larisa Y.; Osna, Natalia A.

Ethanol attenuates presentation of cytotoxic T-lymphocyte epitopes on hepatocytes of HBV-infected humanized mice

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH

IF2.7

2021-11-23

OAAI

Ganesan, Murali; Wang, Weimin; Mathews, Saumi; Makarov, Edward; New-Aaron, Moses; Dagur, Raghubendra Singh; Malo, Antje; Protzer, Ulrike; Kharbanda, Kusum K.; Casey, Carol A.; Poluektova, Larisa Y.; Osna, Natalia A.

CD4+effector T cells accelerate Alzheimer's disease in mice CD4效应T细胞加速小鼠阿尔茨海默病

JOURNAL OF NEUROINFLAMMATION

IF10.1

2021-11-19

OAAI

Machhi, Jatin; Yeapuri, Pravin; Lu, Yaman; Foster, Emma; Chikhale, Rupesh; Herskovitz, Jonathan; Namminga, Krista L.; Olson, Katherine E.; Abdelmoaty, Mai Mohamed; Gao, Ju; Quadros, Rolen M.; Kiyota, Tomomi; Liang Jingjing; Kevadiya, Bhavesh D.; Wang, Xinglong; Liu, Yutong; Poluektova, Larisa Y.; Gurumurthy, Channabasavaiah B.; Mosley, R. Lee; Gendelman, Howard E.

Recovery of Latent HIV-1 from Brain Tissue by Adoptive Cell Transfer in Virally Suppressed Humanized Mice

JOURNAL OF NEUROIMMUNE PHARMACOLOGY

IF3.5

2021-09-15

OAAI

Su, Hang; Sravanam, Sruthi; Sillman, Brady; Waight, Emiko; Makarov, Edward; Mathews, Saumi; Poluektova, Larisa Y.; Gorantla, Santhi; Gendelman, Howard E.; Dash, Prasanta K.

研究方向