Karen Joy Shaw - Publications, H-index & Citations

Karen Joy Shaw

Case Western Reserve University

52H指数

158论文数

8.3K被引数

收录论文 56

发表时间

Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2023-04-18

OAAI

Hodges, Michael R.; Ople, Eric; Wedel, Pamela; Shaw, Karen J.; Jakate, Abhijeet; Kramer, William G.; van Marle, Sjoerd; van Hoogdalem, Ewoud-Jan; Tawadrous, Margaret

Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis

MBIO

IF4.7

2022-12-20

OAAI

Giamberardino, Charles D.; Schell, Wiley A.; Tenor, Jennifer L.; Toffaletti, Dena L.; Palmucci, Julia R.; Marius, Choiselle; Boua, Jane-Valeriane K.; Soltow, Quinlyn; Mansbach, Robert; Moseley, M. Arthur; Thompson, J. Will; Dubois, Laura G.; Hope, William; Perfect, John R.; Shaw, Karen Joy

Characteristics of patients and exacerbations in the ongoing Asthma: Phenotyping Exacerbations (APEX) studies.

EUROPEAN RESPIRATORY JOURNAL

IF21

2022-12-01

PREAI

Pradhan, A.; Needham, R.; Shaw, K.; Martin, M.; Portelli, M.; Sayers, I.; Harrison, T.

The Combination Treatment of Fosmanogepix and Liposomal Amphotericin B Is Superior to Monotherapy in Treating Experimental Invasive Mold Infections Fosmanogepix和脂质体两性霉素b的联合治疗在治疗实验性侵袭性霉菌感染方面优于单药治疗

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2022-07-19

OAAI

Gebremariam, Teclegiorgis; Gu, Yiyou; Alkhazraji, Sondus; Youssef, Eman; Shaw, Karen Joy; Ibrahim, Ashraf S.

In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2021-09-17

OAAI

Shaheen, Shareef K.; Juvvadi, Praveen R.; Allen, John; Shwab, E. Keats; Cole, D. Christopher; Asfaw, Yohannes G.; Kapoor, Mili; Shaw, Karen Joy; Steinbach, William J.

Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes 研究药物Fosmanogepix的活性部分Manogepix表现出对尖孢镰刀菌和茄镰刀菌物种复合物的体外活性

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2021-05-18

OAAI

Badali, Hamid; Patterson, Hoja P.; Sanders, Carmita J.; Mermella, Barbara; Gibas, Connie F. C.; Ibrahim, Ashraf S.; Shaw, Karen J.; Wiederhold, Nathan P.

A low exhaled nitric oxide level excludes a short-term benefit from inhaled corticosteroids in suspected asthma: A randomized placebo-controlled trial 在疑似哮喘患者中，低呼出气一氧化氮水平排除了吸入糖皮质激素的短期获益: 一项随机安慰剂对照试验

RESPIROLOGY

IF6.3

2021-05-03

OAAI

Sutherland, Lissa; Shaw, Karen; Parrish, Clair; Singleton, Nicola; McKeever, Tricia M.; Stewart, Iain; Shaw, Dominick; Martin, Matthew J.; Harrison, Tim

Therapeutic Potential of Fosmanogepix (APX001) for Intra-abdominal Candidiasis: from Lesion Penetration to Efficacy in a Mouse Model

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2021-03-18

OAAI

Lee, Annie; Wang, Ning; Carter, Claire L.; Zimmerman, Matthew; Dartois, Veronique; Shaw, Karen Joy; Perlin, David S.; Zhao, Yanan

Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of Candida Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2021-02-17

OAAI

Petraitiene, Ruta; Petraitis, Vidmantas; Maung, Bo Bo Win; Mansbach, Robert S.; Hodges, Michael R.; Finkelman, Malcolm A.; Shaw, Karen Joy; Walsh, Thomas J.

In Vitro Activity of Manogepix against Multidrug-Resistant and Panresistant Candida auris from the New York Outbreak

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-10-20

OAAI

Zhu, YanChun; Kilburn, Shannon; Kapoor, Mili; Chaturvedi, Sudha; Shaw, Karen Joy; Chaturvedi, Vishnu

Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-05-21

OAAI

Gebremariam, Teclegiorgis; Alkhazraji, Sondus; Alqarihi, Abdullah; Wiederhold, Nathan P.; Shaw, Karen Joy; Patterson, Thomas F.; Filler, Scott G.; Ibrahim, Ashraf S.

Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-04-21

OAAI

Liston, Sean D.; Whitesell, Luke; Kapoor, Mili; Shaw, Karen Joy; Cowen, Leah E.

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-02-21

OAAI

Alkhazraji, Sondus; Gebremariam, Teclegiorgis; Alqarihi, Abdullah; Gu, Yiyou; Mamouei, Zeinab; Singh, Shakti; Wiederhold, Nathan P.; Shaw, Karen J.; Ibrahim, Ashraf S.

Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2019-12-20

OAAI

Gebremariam, Teclegiorgis; Alkhazraji, Sondus; Gu, Yiyou; Singh, Shakti; Alqarihi, Abdullah; Shaw, Karen Joy; Ibrahim, Ashraf S.

Evaluation of Resistance Development to the Gwt1 Inhibitor Manogepix (APX001A) in Candida Species

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2019-12-20

OAAI

Kapoor, Mili; Moloney, Molly; Soltow, Quinlyn A.; Pillar, Chris M.; Shaw, Karen Joy

Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2019-11-01

OAAI

Wiederhold, Nathan P.; Najvar, Laura K.; Shaw, Karen J.; Jaramillo, Rosie; Patterson, Hoja; Olivo, Marcos; Catano, Gabriel; Patterson, Thomas F.

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IF3.3

2019-03-01

OAAI

Finn, Patricia D.; Rodriguez, David; Kohler, Jill; Jiang, Zhengfeng; Wan, Sindy; Blanco, Erick; King, Andrew J.; Chen, Tao; Bell, Noah; Dragoli, Dean; Jacobs, Jeffrey W.; Jain, Rakesh; Leadbetter, Michael; Siegel, Matthew; Carreras, Christopher W.; Koo-McCoy, Samantha; Shaw, Karen; Le, Cathy; Vanegas, Sandra; Hsu, I-Hsin; Kozuka, Kenji; Okamoto, Keiko; Caldwell, Jeremy S.; Lewis, Jason G.

APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2019-02-01

OAAI

Viriyakosol, Suganya; Kapoor, Mili; Okamoto, Sharon; Covel, Jonathan; Soltow, Quinlyn A.; Trzoss, Michael; Shaw, Karen Joy; Fierer, Joshua

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2019-02-01

OAAI

Gebremariam, Teclegiorgis; Alkhazraji, Sondus; Alqarihi, Abdullah; Jeon, Heewon H.; Gu, Yiyou; Kapoor, Mili; Shaw, Karen J.; Ibrahim, Ashraf S.

Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2018-10-01

OAAI

Zhao, Yanan; Lee, Min Hee; Paderu, Padmaja; Lee, Annie; Jimenez-Ortigosa, Cristina; Park, Steven; Mansbach, Robert S.; Shaw, Karen Joy; Perlin, David S.

研究方向