未登录 Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth 使用稳定类天然HIV-1 Env免疫原的实验医学研究能够驱动长期抗体应答，但缺乏广谱中和能力。 Pollock, Katrina M.; Cheeseman, Hannah M.; Mcfarlane, Leon R.; Day, Suzanne; Tolazzi, Monica; Turner, Hannah L.; Joypooranachandran, Jennifer; Shramko, Katsiaryna; Dispinseri, Stefania; Mundsperger, Philipp; Bontjer, Ilja; Lemm, Nana-Marie; Coelho, Sofia; Tanaka, Maniola; Cole, Tom; Korber, Bette; Katinger, Dietmar; Sattentau, Quentin J.; Ward, Andrew B.; Scarlatti, Gabriella; Sanders, Rogier W.; Shattock, Robin J. 分享 收藏
Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted ( vol 15, 6851 , 2024) Deimel, Lachlan P.; Moynie, Lucile; Sun, Guoxuan; Lewis, Viliyana; Turner, Abigail; Buchanan, Charles J.; Burnap, Sean A.; Kutuzov, Mikhail; Kobras, Carolin M.; Demyanenko, Yana; Mohammed, Shabaz; Stracy, Mathew; Struwe, Weston B.; Baldwin, Andrew J.; Naismith, James; Davis, Benjamin G.; Sattentau, Quentin J. 分享 收藏
Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted Deimel, Lachlan P.; Moynie, Lucile; Sun, Guoxuan; Lewis, Viliyana; Turner, Abigail; Buchanan, Charles J.; Burnap, Sean A.; Kutuzov, Mikhail; Kobras, Carolin M.; Demyaneko, Yana; Mohammed, Shabaz; Stracy, Mathew; Struwe, Weston B.; Baldwin, Andrew J.; Naismith, James; Davis, Benjamin G.; Sattentau, Quentin J. 分享 收藏
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis Drexhage, Linnea Z.; Zhang, Shengpan; Dupont, Maeva; Ragaller, Franziska; Sjule, Ellen; Cabezas-Caballero, Jose; Deimel, Lachlan P.; Robertson, Helen; Russell, Rebecca A.; Dushek, Omer; Sezgin, Erdinc; Karaji, Niloofar; Sattentau, Quentin J. 分享 收藏
Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens Martin, Gregory M.; Russell, Rebecca A.; Mundsperger, Philip; Harris, Scarlett; Jovanoska, Lu; Trajano, Luiza Farache; Schiffner, Torben; Fabian, Katalin; Tolazzi, Monica; Scarlatti, Gabriella; McFarlane, Leon; Cheeseman, Hannah; Aldon, Yoann; Schermer, Edith E.; Breemen, Marielle; Sliepen, Kwinten; Katinger, Dietmar; Kunert, Renate; Sanders, Rogier W.; Shattock, Robin; Ward, Andrew B.; Sattentau, Quentin J. 分享 收藏
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High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers del Moral-Sanchez, Ivan; Russell, Rebecca A.; Schermer, Edith E.; Cottrell, Christopher A.; Allen, Joel D.; de la Pena, Alba Torrents; LaBranche, Celia C.; Kumar, Sanjeev; Crispin, Max; Ward, Andrew B.; Montefiori, David C.; Sattentau, Quentin J.; Sliepen, Kwinten; Sanders, Rogier W. 分享 收藏
Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers (vol 6, 134, 2021) Sliepen, Kwinten; Schermer, Edith; Bontjer, Ilja; Burger, Judith A.; Levai, Reka Felfodine; Mundsperger, Philipp; Brouwer, Philip J. M.; Tolazzi, Monica; Farsang, Attila; Katinger, Dietmar; Moore, John P.; Scarlatti, Gabriella; Shattock, Robin J.; Sattentau, Quentin J.; Sanders, Rogier W. 分享 收藏
Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques Bewley, Kevin R.; Gooch, Karen; Thomas, Kelly M.; Longet, Stephanie; Wiblin, Nathan; Hunter, Laura; Chan, Kin; Brown, Phillip; Russell, Rebecca A.; Ho, Catherine; Slack, Gillian; Humphries, Holly E.; Alden, Leonie; Allen, Lauren; Aram, Marilyn; Baker, Natalie; Brunt, Emily; Cobb, Rebecca; Fotheringham, Susan; Harris, Debbie; Kennard, Chelsea; Leung, Stephanie; Ryan, Kathryn; Tolley, Howard; Wand, Nadina; White, Andrew; Sibley, Laura; Sarfas, Charlotte; Pearson, Geoff; Rayner, Emma; Xue, Xiaochao; Lambe, Teresa; Charlton, Sue; Gilbert, Sarah; Sattentau, Quentin J.; Gleeson, Fergus; Hall, Yper; Funnell, Simon; Sharpe, Sally; Salguero, Francisco J.; Gorringe, Andrew; Carroll, Miles 分享 收藏
Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers Sliepen, Kwinten; Schermer, Edith; Bontjer, Ilja; Burger, Judith A.; Levai, Reka Felfodine; Mundsperger, Philipp; Brouwer, Philip J. M.; Tolazzi, Monica; Farsang, Atilla; Katinger, Dietmar; Moore, John P.; Scarlatti, Gabriella; Shattock, Robin J.; Sattentau, Quentin J.; Sanders, Rogier W. 分享 收藏
Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization Turner, Hannah L.; Andrabi, Raiees; Cottrell, Christopher A.; Richey, Sara T.; Song, Ge; Callaghan, Sean; Anzanello, Fabio; Moyer, Tyson J.; Abraham, Wuhbet; Melo, Mariane; Silva, Murillo; Scaringi, Nicole; Rakasz, Eva G.; Sattentau, Quentin; Irvine, Darrell J.; Burton, Dennis R.; Ward, Andrew B. 分享 收藏
Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses Hauser, Alexandra; Carnell, George; Held, Kathrin; Sulbaran, Guidenn; Tischbierek, Nadine; Rogers, Lisa; Pollakis, Georgios; Tonks, Paul; Hoelscher, Michael; Ding, Song; Sanders, Rogier W.; Geldmacher, Christof; Sattentau, Quentin; Weissenhorn, Winfried; Heeney, Jonathan L.; Peterhoff, David; Wagner, Ralf 分享 收藏
Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery 通过二氧化硅纳米颗粒递送增强针对稳定的HIV-1进化枝C包膜三聚体的免疫反应 Peterhoff, David; Thalhauser, Stefanie; Sobczak, Jan M.; Mohsen, Mona O.; Voigt, Christoph; Seifert, Nicole; Neckermann, Patrick; Hauser, Alexandra; Ding, Song; Sattentau, Quentin; Bachmann, Martin F.; Breunig, Miriam; Wagner, Ralf 分享 收藏
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Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies (vol 15, e1008026, 2019) LaBranche, Celia C.; Henderson, Rory; Hsu, Allen; Behrens, Shay; Chen, Xuejun; Zhou, Tongqing; Wiehe, Kevin; Saunders, Kevin O.; Alam, S. Munir; Bonsignori, Mattia; Borgnia, Mario J.; Sattentau, Quentin J.; Eaton, Amanda; Greene, Kelli; Gao, Hongmei; Liao, Hua-Xin; Williams, Wilton B.; Peacock, James; Tang, Haili; Perez, Lautaro G.; Edwards, Robert J.; Kepler, Thomas B.; Korber, Bette T.; Kwong, Peter D.; Mascola, John R.; Acharya, Priyamvada; Haynes, Barton F.; Montefiori, David C. 分享 收藏
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies LaBranche, Celia C.; Henderson, Rory; Hsu, Allen; Behrens, Shay; Chen, Xuejun; Zhou, Tongqing; Wiehe, Kevin; Saunders, Kevin O.; Alam, S. Munir; Bonsignori, Mattia; Borgnia, Mario J.; Sattentau, Quentin J.; Eaton, Amanda; Greene, Kelli; Gao, Hongmei; Liao, Hua-Xin; Williams, Wilton B.; Peacock, James; Tang, Haili; Perez, Lautaro G.; Edwards, Robert J.; Kepler, Thomas B.; Korber, Bette T.; Kwong, Peter D.; Mascola, John R.; Acharya, Priyamvada; Haynes, Barton F.; Montefiori, David C. 分享 收藏
HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies (vol 14, e1007431, 2018) LaBranche, Celia C.; McGuire, Andrew T.; Gray, Matthew D.; Behrens, Shay; Chen, Xuejun; Zhou, Tongqing; Sattentau, Quentin J.; Peacock, James; Eaton, Amanda; Greene, Kelli; Gao, Hongmei; Tang, Haili; Perez, Lautaro G.; Saunders, Kevin O.; Kwong, Peter D.; Mascola, John R.; Haynes, Barton F.; Stamatatos, Leonidas; Montefiori, David C. 分享 收藏
HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRCO1-class broadly neutralizing antibodies LaBranche, Celia C.; McGuire, Andrew T.; Gray, Matthew D.; Behrens, Shay; Zhou, Tongqing; Sattentau, Quentin J.; Peacock, James; Eaton, Amanda; Greene, Kelli; Gao, Hongmei; Tang, Haili; Perez, Lautaro G.; Saunders, Kevin O.; Mascola, John R.; Haynes, Barton F.; Stamatatos, Leonidas; Montefiori, David C. 分享 收藏
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