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An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L Nlrp5基因敲除突变会导致卵母细胞中从头甲基化减弱,并伴随DNMT3L显著减少。 Nic Aodha, Leah; Pokhilko, Alexandra; Rosen, Leah U.; Galatidou, Styliani; Walewska, Edyta; Belton, Christian; Galvao, Antonio; Okkenhaug, Hanneke; Yu, Lu; Nakhuda, Asif; Mansfield, Bill; Khan, Soumen; Oxley, David; Barragan, Montserrat; Kelsey, Gavin 分享 收藏
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Molecular insights into the decline in oocyte quality with advanced maternal age: findings from comprehensive single cell omics analysis of 112 human oocytes Galatidou, S.; Peteleski, A.; Mchuggh, L.; Pujol, A.; Lattes, K.; Fair, T.; Vassena, R.; Kelsey, G.; Slavov, N.; Popovic, M.; Barragan, M. 分享 收藏
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FOXA2 controls the anti-oxidant response in FH-deficient cells Rogerson, Connor; Sciacovelli, Marco; Maddalena, Lucas A.; Pouikli, Andromachi; Segarra-Mondejar, Marc; Valcarcel-Jimenez, Lorea; Schmidt, Christina; Yang, Ming; Ivanova, Elena; Kent, Joshua; Mora, Ariane; Cheeseman, Danya; Carroll, Jason S.; Kelsey, Gavin; Frezza, Christian 分享 收藏
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Single-cell multi-omic analysis profiles defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrest Mora, Jose Ramon Hernandez; Buhigas, Claudia; Clark, Stephen; Bonilla, Raquel Del Gallego; Daskeviciute, Dagne; Monteagudo-Sanchez, Ana; Poo-Llanillo, Maria Eugenia; Medrano, Jose Vicente; Simon, Carlos; Meseguer, Marcos; Kelsey, Gavin; Monk, David 分享 收藏
Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis Demond, Hannah; Hanna, Courtney W.; Castillo-Fernandez, Juan; Santos, Fatima; Papachristou, Evangelia K.; Segonds-Pichon, Anne; Kishore, Kamal; Andrews, Simon; D'Santos, Clive S.; Kelsey, Gavin 分享 收藏
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Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses 常见可变免疫缺陷的单细胞图谱显示b细胞反应中与生发中心相关的表观遗传失调 Rodriguez-Ubreva, Javier; Arutyunyan, Anna; Bonder, Marc Jan; Del Pino-Molina, Lucia; Clark, Stephen J.; de la Calle-Fabregat, Carlos; Garcia-Alonso, Luz; Handfield, Louis-Francois; Ciudad, Laura; Andres-Leon, Eduardo; Krueger, Felix; Catala-Moll, Francesc; Rodriguez-Cortez, Virginia C.; Polanski, Krzysztof; Mamanova, Lira; van Dongen, Stijn; Kiselev, Vladimir Yu; Martinez-Saavedra, Maria T.; Heyn, Holger; Martin, Javier; Warnatz, Klaus; Lopez-Granados, Eduardo; Rodriguez-Gallego, Carlos; Stegle, Oliver; Kelsey, Gavin; Vento-Tormo, Roser; Ballestar, Esteban 分享 收藏
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