Ulf J. Nilsson - Publications, H-index & Citations

Ulf J. Nilsson

Lund University

61H指数

366论文数

1.2W被引数

收录论文 120

发表时间

Structural and Biophysical Characterization of C-Glycosylic 1,2-Thiodisaccharides Reveals Determinants of Selective Binding to Galectin-7 and Galectin-8N C-糖苷键1,2-硫二糖的结构和生物物理表征揭示了与半乳糖凝集素-7和半乳糖凝集素-8N选择性结合的决定因素

ChemMedChem

IF3.4

2026-09-08

OAAI

Anastasia S. Tsagkarakou; Anastassia L. Kantsadi; Vasiliki I. Theodoridou; Nikolaos Veliotis; László Lázár; János József; László Juhász; George Kontopidis; Hakon Leffler; Ulf J. Nilsson; László Somsák; Demetres D. Leonidas

An Orally Available Halothiazole Glycomimetic as a Cancer-Targeting Dual Galectin-1 and Galectin-3 Inhibitor 一种口服可用的卤代噻唑类糖模拟物作为靶向癌细胞的半乳糖凝集素-1和半乳糖凝集素-3双重抑制剂

Journal of Medicinal Chemistry

IF6.8

2026-04-29

PREAI

Fredrik R. Zetterberg; Kristoffer Peterson; Ulf J. Nilsson; Carl Diehl; Maria Håkansson; Barbro Kahl-Knutson; Alison C. MacKinnon; Hanna Klein; Hakon Leffler; James A. Roper; Robert J. Slack; Henrik von Wachenfeldt; Anders Pedersen

β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors β-甘露糖基三唑作为半乳糖基凝集素-3和凝集素-9 N末端结构域抑制剂的模拟物

ChemBioChem

IF2.8

2026-04-13

OAAI

Fredrik Sjövall; Ulf J. Nilsson

A Regioselective Synthesis of 2; 4-Disubstituted 2H-1; 2; 3-Triazoles by Coupling of N-Tosylhydrazones and Anhydro-Aldose Tosylhydrazones with 4-Substituted 1H-1; 2; 3-Triazoles – Scope and Limitations 2; 4-位取代的2H-1; 2; 3-三唑的区域选择性合成：通过N-甲苯磺酰基肼和脱水醛糖甲苯磺酰基肼与4-取代的1H-1; 2; 3-三唑的偶联反应——反应范围与局限性

ACS Omega

IF4.3

2025-12-08

OAAI

Bence Szakács; Tímea Kaszás; Éva Juhász-Tóth; Ivett Cservenyák; István Timári; Ulf J. Nilsson; Luca A. Varga; Tibor Docsa; Viktória Molnár; Andrea Enikő Kulcsár; Lili Márton; Anita Ábrahám; Attila Kiss-Szikszai; János József; László Juhász; László Somsák; Marietta Tóth

Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate α5β1整合素上的空间N-糖链重排使半乳凝素-3寡聚体成核，以决定内吞命运。

Nature Communications

IF15.7

2025-10-27

OAAI

Massiullah Shafaq-Zadah; Estelle Dransart; Ilyes Hamitouche; Christian Wunder; Valérie Chambon; Cesar A. Valades-Cruz; Ludovic Leconte; Nirod Kumar Sarangi; Jack Robinson; Siau-Kun Bai; Raju Regmi; Aurélie Di Cicco; Agnès Hovasse; Richard Bartels; Ulf J. Nilsson; Sarah Cianférani-Sanglier; Hakon Leffler; Tia E. Keyes; Daniel Lévy; Stefan Raunser; Daniel Roderer; Ludger Johannes

Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition C1和C3位上三唑基取代基与半乳糖的协同作用，用于高亲和力和选择性半乳凝素-4C抑制

RSC Chem. Biol.

IF3.1

2025-08-06

OAAI

Alexander Dahlqvist; Rob Marc Go; Chandan Kishor; Hakon Leffler; Helen Blanchard; Ulf J. Nilsson

Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction (vol 8, 59, 2025)Galectin-8 N末端域的纳摩尔级抑制剂的结合是通过非经典阳离子-π相互作用实现的（卷8，59，2025）

COMMUNICATIONS CHEMISTRY

IF6.2

2025-04-01

OAAI

Puric, Edvin; Hassan, Mujtaba; Sjovall, Fredrik; Tomasic, Tihomir; Pevec, Mojca; Lah, Jurij; Forteza, Jaume Adrover; Sundin, Anders; Leffler, Hakon; Nilsson, Ulf J.; Logan, Derek T.; Anderluh, Marko

Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction

COMMUNICATIONS CHEMISTRY

IF6.2

2025-02-24

OAAI

Puric, Edvin; Hassan, Mujtaba; Sjovall, Fredrik; Tomasic, Tihomir; Pevec, Mojca; Lah, Jurij; Forteza, Jaume Adrover; Sundin, Anders; Leffler, Hakon; Nilsson, Ulf J.; Logan, Derek T.; Anderluh, Marko

Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-12-12

PREAI

Peterson, Kristoffer; Nilsson, Ulf J.; Gravelle, Lise; Holyer, Ian; Jansson, Karl; Kahl-Knutson, Barbro; Leffler, Hakon; Mackinnon, Alison C.; Roper, James A.; Slack, Robert J.; von Wachenfeldt, Henrik; Pedersen, Anders; Zetterberg, Fredrik R.

Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2024-12-01

PREAI

Mackinnon, Alison C.; Humphries, Duncan C.; Herman, Kimberley; Roper, James A.; Holyer, Ian; Mabbitt, Joseph; Mills, Ross; Nilsson, Ulf J.; Leffler, Hakon; Pedersen, Anders; Schambye, Hans; Zetterberg, Fredrik; Slack, Robert J.

Sulfonamide-derivatized galactosides selectively target an unexplored binding site in the galectin-9N-terminal domain

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2024-12-01

OAAI

Mahanti, Mukul; Gummesson, Sofi; Sundin, Anders; Leffler, Hakon; Zetterberg, Fredrik; Nilsson, Ulf J.

VASCULAR PHARMACOLOGY

IF3.5

2024-09-01

PREAI

Arevalo-Martinez, Marycarmen; Ede, Jacob; van der Have, Oscar; Ritsvall, Olivia; Zetterberg, Fredrik R.; Nilsson, Ulf J.; Leffler, Hakon; Holmberg, Johan; Albinsson, Sebastian

Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-07-22

OAAI

van Klaveren, Sjors; Hassan, Mujtaba; Hakansson, Maria; Johnsson, Richard E.; Larsson, Jessica; Jakopin, Ziga; Anderluh, Marko; Leffler, Hakon; Tomasic, Tihomir; Nilsson, Ulf J.

Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer 发现选择性和口服Galectin-1抑制剂GB1908作为肺癌的潜在治疗方法

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-05-28

PREAI

Zetterberg, Fredrik R.; Peterson, Kristoffer; Nilsson, Ulf J.; Dahlgren, Kajsa Andreasson; Diehl, Carl; Holyer, Ian; Hakansson, Maria; Khabut, Areej; Kahl-Knutson, Barbro; Leffler, Hakon; MacKinnon, Alison C.; Roper, James A.; Slack, Robert J.; Zarrizi, Reihaneh; Pedersen, Anders

Galectin-8 inhibition and functions in immune response and tumor biology

MEDICINAL RESEARCH REVIEWS

IF11.6

2024-04-13

OAAI

Puric, Edvin; Nilsson, Ulf J.; Anderluh, Marko

Development of a novel AAK1 inhibitor via Kinobeads-based screening

SCIENTIFIC REPORTS

IF3.9

2024-03-20

OAAI

Yoshida, Akari; Ohtsuka, Satomi; Matsumoto, Fumiya; Miyagawa, Tomoyuki; Okino, Rei; Ikeda, Yumeya; Tada, Natsume; Gotoh, Akira; Magari, Masaki; Hatano, Naoya; Morishita, Ryo; Satoh, Ayano; Sunatsuki, Yukinari; Nilsson, Ulf J.; Ishikawa, Teruhiko; Tokumitsu, Hiroshi

Discovery of Selective and Orally Available Galectin-1 Inhibitors 选择性和口服Galectin-1抑制剂的发现

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-12-07

PREAI

Zetterberg, Fredrik R.; Diehl, Carl; Hakansson, Maria; Kahl-Knutson, Barbro; Leffler, Hakon; Nilsson, Ulf J.; Peterson, Kristoffer; Roper, James A.; Slack, Robert J.

Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds 配体硫氧化态逐渐改变Galectin-3-Ligand复杂构象，以诱导影响亲和力的氢键

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-10-25

OAAI

Mahanti, Mukul; Pal, Kumar Bhaskar; Kumar, Rohit; Schulze, Markus; Leffler, Hakon; Logan, Derek T.; Nilsson, Ulf J.

Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3?Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-09-02

PREAI

Lazar, Laszlo; Tsagkarakou, Anastasia S.; Stravodimos, George; Kontopidis, George; Leffler, Hakon; Nilsson, Ulf J.; Somsak, Laszlo; Leonidas, Demetres D.

Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-08-28

OAAI

Mabbitt, Joseph; Holyer, Ian D.; Roper, James A.; Nilsson, Ulf J.; Zetterberg, Fredrik R.; Vuong, Lynda; Mackinnon, Alison C.; Pedersen, Anders; Slack, Robert J.

研究方向