Shaoyong Lu - Publications, H-index & Citations

陆

陆绍永 (Shaoyong Lu)

ningxia medical university

49H指数

174论文数

7.6K被引数

收录论文 100

发表时间

Molecular glues as GPCR modulators: unveiling three distinct mechanistic pathways for signal regulation 分子胶作为GPCR调节剂：揭示信号调控的三种不同机制途径

Drug Discovery Today

IF7.5

2025-09-24

PREAI

Yuxuan Xing; Jianyang Ao; Xiaoli Zhu; Zhengjun Chai; Shaoyong Lu

Recent advances in computational strategies for allosteric site prediction: Machine learning, molecular dynamics, and network-based approaches 近期用于变构位点预测的计算策略研究进展：机器学习、分子动力学和网络基础方法

Drug Discovery Today

IF7.5

2025-09-04

PREAI

Jianxiang Huang; Guo Tang; Ning Liu; Xiaolong Li; Shaoyong Lu

Mechanistic basis of N-terminal domain-mediated allostery in SIRT6: integrating molecular dynamics simulations and biochemical assays N端结构域介导的SIRT6别构作用的机制基础：整合分子动力学模拟和生物化学实验

Molecular Diversity

IF3.8

2025-08-30

PREAI

Haiyue Tang; Wenjie Ma; Guoyou Zhang; Jiacheng Wei; Jianyang Ao; Shaoyong Lu

Identification of an Unexplored Dynamic Allosteric Site on the Activation Pathway of the Vasopressin V2 Receptor 在血管加压素V2受体激活途径中鉴定出一个未被探索的动态别构位点

Journal of Medicinal Chemistry

IF6.8

2025-07-16

PREAI

Xin Qiao; Chunhao Zhu; Xiaobing Lan; Mingyu Li; Nuan Li; Jianxiang Huang; Ning Liu; Jian Zhang; Shaoyong Lu

Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling 通过多副本分子动力学模拟和马尔可夫状态建模，探索神经介素B受体的不同激活机制

Acta Pharmacologica Sinica

IF8.4

2025-06-27

PREAI

Nuan Li; Ming-yuan Yang; Ming-yang Zhang; Ning Liu; Ai-wu Zhou; Zong-tao Chai; Shao-yong Lu

Decoding allosteric landscapes: computational methodologies for enzyme modulation and drug discovery

RSC CHEMICAL BIOLOGY

IF3.1

2025-01-01

OAAI

Zhu, Ruidi; Wu, Chengwei; Zha, Jinyin; Lu, Shaoyong; Zhang, Jian

Designed dualsteric modulators: A novel route for drug discovery 设计的二元调节剂: 药物发现的新途径

DRUG DISCOVERY TODAY

IF7.5

2024-10-01

PREAI

Li, Nuan; Zheng, Guodong; Fu, Lili; Liu, Ning; Chen, Ting; Lu, Shaoyong

Exploring the constitutive activation mechanism of the class A orphan GPR20

ACTA PHARMACOLOGICA SINICA

IF8.4

2024-09-10

PREAI

Zhang, Ming-yang; Ao, Jian-yang; Liu, Ning; Chen, Ting; Lu, Shao-yong

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5

NATURE COMMUNICATIONS

IF15.7

2024-08-30

OAAI

Li, Mingyu; Lan, Xiaobing; Shi, Xinchao; Zhu, Chunhao; Lu, Xun; Pu, Jun; Lu, Shaoyong; Zhang, Jian

G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery G蛋白偶联受体 (gpcr): 结构，机制和药物发现的进展

Signal Transduction and Targeted Therapy

IF52.7

2024-04-10

352

OAAI

Zhang, Mingyang; Chen, Ting; Lu, Xun; Lan, Xiaobing; Chen, Ziqiang; Lu, Shaoyong

Progressive computational approaches to facilitate decryption of allosteric mechanism and drug discovery

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2023-12-01

PREAI

Lu, Xun; Lan, Xiaobing; Lu, Shaoyong; Zhang, Jian

Pharmacologically targeting intracellular allosteric sites of GPCRs for drug discovery 药理学靶向gpcr的细胞内变构位点用于药物发现

DRUG DISCOVERY TODAY

IF7.5

2023-12-01

PREAI

Zhang, Mingyang; Lan, Xiaobing; Li, Xiaolong; Lu, Shaoyong

ASD2023: towards the integrating landscapes of allosteric knowledgebase ASD2023: 走向变构知识库的整合景观

NUCLEIC ACIDS RESEARCH

IF13.1

2023-10-23

OAAI

He, Jixiao; Liu, Xinyi; Zhu, Chunhao; Zha, Jinyin; Li, Qian; Zhao, Mingzhu; Wei, Jiacheng; Li, Mingyu; Wu, Chengwei; Wang, Junyuan; Jiao, Yonglai; Ning, Shaobo; Zhou, Jiamin; Hong, Yue; Liu, Yonghui; He, Hongxi; Zhang, Mingyang; Chen, Feiying; Li, Yanxiu; He, Xinheng; Wu, Jing; Lu, Shaoyong; Song, Kun; Lu, Xuefeng; Zhang, Jian

Angiogenic Activity and Mechanism for Bisphenols on Endothelial Cell and Mouse: Evidence of a Structural-Selective Effect

ENVIRONMENTAL SCIENCE & TECHNOLOGY

IF11.3

2023-07-28

PREAI

Lu, Liping; Shen, Lilai; Cui, Shixuan; Huang, Yizhou; Gao, Yuchen; Zhu, Xiaoming; Lu, Shaoyong; Zhang, Chunlong; Zhuang, Shulin

Mechanistic Elucidation of Activation/Deactivation Signal Transduction within Neurotensin Receptor 1 Triggered by 'Driver Chemical Groups' of Modulators: A Comparative Molecular Dynamics Simulation

PHARMACEUTICS

IF5.5

2023-07-21

OAAI

Lu, Xun; Shi, Xinchao; Fan, Jigang; Li, Mingyu; Zhang, Yuxiang; Lu, Shaoyong; Xu, Guanghuan; Chen, Ziqiang

AlloReverse: multiscale understanding among hierarchical allosteric regulations

NUCLEIC ACIDS RESEARCH

IF13.1

2023-04-18

OAAI

Zha, Jinyin; Li, Qian; Liu, Xinyi; Lin, Weidong; Wang, Tingting; Wei, Jiacheng; Zhang, Ziliang; Lu, Xun; Wu, Jing; Ni, Duan; Song, Kun; Zhang, Liang; Lu, Xuefeng; Lu, Shaoyong; Zhang, Jian

Decoding the Conformational Selective Mechanism of FGFR Isoforms: A Comparative Molecular Dynamics Simulation

MOLECULES

IF4.6

2023-03-17

OAAI

Zhang, Mingyang; Yasen, Miersalijiang; Lu, Shaoyong; Ma, De-Ning; Chai, Zongtao

Structural Understanding of Peptide-Bound G Protein-Coupled Receptors: Peptide-Target Interactions

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-01-10

PREAI

Shi, Yuxin; Chen, Yi; Deng, Liping; Du, Kui; Lu, Shaoyong; Chen, Ting

Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of Adhesion Receptor GPR97

PHARMACEUTICS

IF5.5

2022-09-02

OAAI

Zhang, Hao; Chu, Guojun; Wang, Gaoming; Yao, Min; Lu, Shaoyong; Chen, Ting

Rational design of a sensitivity-enhanced tracer for discovering efficient APC-Asef inhibitors

NATURE COMMUNICATIONS

IF15.7

2022-08-24

PREAI

Zhong, Jie; Guo, Yuegui; Lu, Shaoyong; Song, Kun; Wang, Ying; Feng, Li; Zheng, Zhen; Zhang, Qiufen; Wei, Jiacheng; Sang, Peng; Shi, Yan; Cai, Jianfeng; Chen, Guoqiang; Liu, Chen-Ying; Yang, Xiuyan; Zhang, Jian

研究方向