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Elucidation of a Novel Binding Pocket for a Positive Allosteric Modulator of the D1 Dopamine Receptor 阐明一种D1多巴胺受体的正向别构调节剂的全新结合位点 Dimova, Snezana; Hanson, John N.; Xu, Youwei; Wang, Kai; Liu, Yini; Son, Ashley Nil; Goldberg, Alexander; Xie, Bing; Thakur, Abhishek; Wang, Feijun; Rayadurgam, Jayachandra; Moritz, Amy; Luderman, Kathryn D.; Free, Benjamin; Frankowski, Kevin J.; Shi, Lei; Zhuang, Youwen; Xu, Eric; Sibley, David R. 分享 收藏
Neuroprotection in C. Elegans Models of Parkinson's Disease: Discovering Therapeutics Via Small Molecule and RNA Interference 帕金森病C. Elegans模型中的神经保护：通过小分子和RNA干扰发现治疗药物 Martinez, Miguel a.; Akano, Emmanuel o.; Surtel, Alexis a.; Dranchak, Patricia k.; Ash, Carl t.; Anderson, Emily e.; Moritz, Amy; Free, R. benjamin; Steiner, Joseph p.; Inglese, James; Sibley, David r. 分享 收藏
G Protein-Coupled Receptor Kinase Isoforms Differentially Regulate Dopamine Receptor Subtypes G蛋白偶联受体激酶异构体差异调控多巴胺受体亚型 Moritz, Amy; Madaras, Nora s.; Snyder, Kirsten k.; Boldizsar, Noelia m.; Haider, Raphael; Drube, Julia; Ghosh, Arun k.; Tesmer, John; Hoffmann, Carsten; Sibley, David r. 分享 收藏
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Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder Boateng, Comfort A.; Nilson, Ashley N.; Placide, Rebekah; Pham, Mimi L.; Jakobs, Franziska M.; Boldizsar, Noelia; Mcintosh, Scot; Stallings, Leia S.; Korankyi, Ivana V.; Kelshikar, Shreya; Shah, Nisha; Panasis, Diandra; Muccilli, Abigail; Ladik, Maria; Maslonka, Brianna; McBride, Connor; Sanchez, Moises Ximello; Akca, Ebrar; Alkhatib, Mohammad; Saez, Julianna; Nguyen, Catherine; Kurtyan, Emily; DePierro, Jacquelyn; Crowthers, Raymond; Brunt, Dylan; Bonifazi, Alessandro; Newman, Amy Hauck; Rais, Rana; Slusher, Barbara S.; Free, R. Benjamin; Sibley, David R.; Stewart, Kent D.; Wu, Chun; Hemby, Scott E.; Keck, Thomas M. 分享 收藏
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Structure-Activity Relationships of a Brain-Penetrant D3 Dopamine Receptor Negative Allosteric Modulator and Investigation of its Binding Site Moritz, Amy E.; Madaras, Nora S.; Inbody, Laura R.; Kelley, Amber M.; Gandhi, Disha M.; Akano, Emmanuel O.; Lee, Kuo H.; Free, R. Benjamin; Hu, Xin; Southall, Noel T.; Ferrer, Marc; Shi, Lei; Frankowski, Kevin J.; Sibley, David R. 分享 收藏
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Bioisosteric Replacement of Amides Linkers with 1, 2, 3-Triazoles for Improved Pharmacokinetics Without Losing Dopamine D4 Receptor Potency or Selectivity Panasis, Diandra; Alkhatib, Mohammad; Saez, Julianna; Hanson, John; Nilson, Ashley N.; Jacobs, Franziska M.; Kasarla, Nitish; Wang, Bryant; Ladik, Maria; Muccilli, Abigail; Hong, Kaylen; Free, R. Benjamin; Sibley, David R.; Boateng, Comfort A.; Keck, Thomas 分享 收藏
Delineation of the G Protein-Coupled Receptor Kinase Phosphorylation Sites Within the D1 Dopamine Receptor and Their Role in Regulating Receptor Function Madaras, Nora S.; Rankin, Michele L.; Free, R. Benjamin; Haider, Raphael; Drube, Julia; Ghosh, Arun K.; Tesmer, John J. G.; Hoffmann, Carsten; Sibley, David R.; Moritz, Amy E. 分享 收藏
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Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search Bonaventura, Jordi; Gomez, Juan L.; Carlton, Meghan L.; Lam, Sherry; Sanchez-Soto, Marta; Morris, Patrick J.; Moaddel, Ruin; Kang, Hye Jin; Zanos, Panos; Gould, Todd D.; Thomas, Craig J.; Sibley, David R.; Zarate, Carlos A., Jr.; Michaelides, Michael 分享 收藏
The show must go on. Reply to Distinct functions of S-ketamine and R-ketamine in mediating biobehavioral processes of drug dependency: comments on Bonaventura et al by Insop Shim Bonaventura, Jordi; Lam, Sherry; Carlton, Meghan; Boehm, Matthew; Gomez, Juan L.; Solis, Oscar; Sanchez-Soto, Marta; Morris, Patrick J.; Fredriksson, Ida; Thomas, Craig J.; Sibley, David R.; Shaham, Yavin; Zarate, Carlos A., Jr.; Michaelides, Michael 分享 收藏
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Structure-Activity Relationships of a Negative Allosteric Modulator of the D3 Dopamine Receptor and Investigation of its Binding Site Moritz, Amy E.; Madaras, Nora S.; Inbody, Laura R.; Kelley, Amber M.; Gandhi, Disha M.; Akano, Emmanuel; Lee, Kuo H.; Free, R. B.; Hu, Xin; Southall, Noel T.; Ferrer, Mare; Shi, Lei; Frankowski, Kevin J.; Sibley, David R. 分享 收藏
Characterization and Chemical Optimization of the D2 Dopamine Receptor-Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disorders Nilson, Ashley N.; Garcia, Andres Dulcey; Free, R. B.; Boldizsar, Noelia; Pearlstein, Hannah; Rocereta, Julia A.; Rodriguiz, Ramona M.; Lane, J. R.; Lee, Kuo H.; Shi, Lei; Wetsel, William C.; Marugan, Juan J.; Sibley, David R. 分享 收藏
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Pharmacological actions of a novel and highly selective D3 dopamine receptor agonist, ML417, in a rodent model of Parkinson's disease Akano, Emmanuel O.; Novikov, Nikolay; Brazhnik, Elena; Moritz, Amy E.; Mccoy, Alex J.; Free, R. B.; Walters, Judith R.; Sibley, David R. 分享 收藏
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