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收藏分享 收藏 分享 收藏 Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease发现一种强效共价抑制剂，其异常扭曲了SARS-CoV-2主蛋白酶的催化二联体
Wang, Juan; Sang, Xiaohong; Zheng, Wenyan; Chan, Jasper Fuk-Woo; Zhou, Jiao; Xu, Yan; Han, Pu; Feng, Yong; Fu, Lifeng; Tsang, Jessica Oi-Ling; Yuan, Shuofeng; Ciechanover, Aaron; An, Jing; Yuen, Kwok-Yung; Qi, Jianxun; Huang, Ziwei 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspotsSARS-CoV-2 JN.1逃逸株通过靶向两个细胞毒性T细胞表位热点实现T细胞免疫逃逸Tian, Jinmin; Shang, Bingli; Zhang, Jianing; Guo, Yuanyuan; Li, Min; Hu, Yuechao; Bai, Dan; She, Junying; Han, Yang; Guo, Peipei; Huang, Mengkun; Wang, Yalan; Liu, Maoshun; Zhang, Jie; Ye, Beiwei; Guo, Yaxin; Yang, Mengjie; Lin, Ying; Zhang, Ting; Sun, Xin; Yuan, Xiaoju; Zhang, Danni; Xu, Ziqian; Chai, Yan; Qi, Jianxun; Liu, Kefang; Zhao, Yingze; Zhou, Jikun; Song, Rui 分享 收藏 Precise motif and cross-presentation of coronavirus peptides by feline MHC class I: implications for the mild infection of SARS-CoV-2Qiao, Peiwen; Yue, Can; Peng, Weiyu; Liu, Kefang; Huo, Shuting; Zhang, Di; Chai, Yan; Qi, Jianxun; Sun, Zeyu; Gao, George F.; Wu, Guizhen; Liu, Jun 分享 收藏 分享 收藏 De Novo Discovery of a Noncovalent Cell-Penetrating Bicyclic Peptide Inhibitor Targeting SARS-CoV-2 Main Protease靶向SARS-CoV-2主要蛋白酶的非共价细胞穿透双环肽抑制剂的从头发现Tan, Yahong; Yang, Jinyue; Wang, Min; Peng, Qi; Li, Yongqi; Fu, Lifeng; Zhang, Mengmeng; Wu, Jiang; Yang, Guanya; Hipolito, Christopher John; Zhang, Youming; Qi, Jianxun; Shi, Yi; Yin, Yizhen 分享 收藏 分享 收藏 NS2 induces an influenza A RNA polymerase hexamer and acts as a transcription to replication switch (July, 10.1038/s44319-024-00208-4, 2024)Sun, Junqing; Kuai, Lu; Zhang, Lei; Xie, Yufeng; Zhang, Yanfang; Li, Yan; Peng, Qi; Shao, Yuekun; Yang, Qiuxian; Tian, Wen-Xia; Zhu, Junhao; Qi, Jianxun; Shi, Yi; Deng, Tao; Gao, George F. 分享 收藏 Structural characteristics of BtKY72 RBD bound to bat ACE2 reveal multiple key residues affecting ACE2 usage of sarbecovirusesSu, Chao; He, Juanhua; Wang, Liang; Hu, Yu; Cao, Jian; Bai, Bin; Qi, Jianxun; Gao, George Fu; Yang, Mengsu; Wang, Qihui 分享 收藏 Protective RBD-dimer vaccines against SARS-CoV-2 and its variants produced in glycoengineered Pichia pastorisZhao, Tongxin; Liu, Sheng; Wang, Pengyan; Zhang, Yanfang; Kang, Xinrui; Pan, Xiaoqian; Li, Linjie; Li, Dedong; Gao, Ping; An, Yaling; Song, Hao; Liu, Kefang; Qi, Jianxun; Zhao, Xin; Dai, Lianpan; Liu, Peipei; Wang, Peiyi; Wu, Guizhen; Zhu, Taicheng; Xu, Kun; Li, Yin; Gao, George F. 分享 收藏 分享 收藏 NS2 induces an influenza A RNA polymerase hexamer and acts as a transcription to replication switchSun, Junqing; Kuai, Lu; Zhang, Lei; Xie, Yufeng; Zhang, Yanfang; Li, Yan; Peng, Qi; Shao, Yuekun; Yang, Qiuxian; Tian, Wen-Xia; Zhu, Junhao; Qi, Jianxun; Shi, Yi; Deng, Tao; Gao, George F. 分享 收藏 Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model靶向SFTSV上两种糖蛋白的双特异性抗体在小鼠模型中表现出协同中和和保护作用Chang, Zhen; Gao, Dan; Liao, Liying; Sun, Junqing; Zhang, Gen; Zhang, Xue; Wang, Feiran; Li, Chunrui; Oladejo, Babayemi Olawale; Li, Shihua; Chai, Yan; Hu, Yongfei; Lu, Xuancheng; Xiao, Haixia; Qi, Jianxun; Chen, Zhihai; Gao, Feng; Wu, Yan 分享 收藏 Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1Tong, Zhou; Tong, Jianyu; Lei, Wenwen; Xie, Yufeng; Cui, Yingzi; Jia, Guowen; Li, Shihua; Zhang, Zezhong; Cheng, Zhimin; Xing, Xiao; Ma, Haiyun; Deng, Lan; Zhang, Rong; Zhao, Xin; Liu, Kefang; Wang, Qihui; Qi, Jianxun; Huang, Haomin; Song, Rui; Su, Zhaoming; Wu, Guizhen; Lou, Jing; Gao, George Fu 分享 收藏 
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