Guido J.R. Zaman

oncolines b.v.

39H指数

224论文数

5.3K被引数

收录论文 84

发表时间

Comparative profiling of osimertinib and fourth-generation EGFR inhibitors on EGFR-mutant proteins and cell lines 奥希替尼和第四代EGFR抑制剂在EGFR突变蛋白和细胞系中的比较分析

Frontiers in Oncology

IF3.3

2026-09-22

OAAI

JJ Janneke J. T. M. Melis; KJ Kirsten J. W. Kevenaar; JY Jacob Ytsma; DJ Daphne J. F. Kluitmans; JM Janneke M. van den End; JJ Jeffrey J. Kooijman; JL Jonne L. K. van Eck; EV Esmee van den Bossche; JA Jeroen A. D. M. de Roos; YK Yusuke Kawase; NW Nicole Willemsen-Seegers; YG Yvonne Grobben; GJ Guido J. R. Zaman

Combined cellular and biochemical profiling of Bruton’s tyrosine kinase inhibitor nemtabrutinib reveals potential application in MAPK-driven cancers 联合细胞和生物化学分析表明，Bruton’s tyrosine kinase抑制剂nemtabrutinib在MAPK驱动的癌症中具有潜在应用价值。

Frontiers in Oncology

IF3.3

2025-10-22

OAAI

Daphne J. F. Kluitmans; Janneke J. T. M. Melis; Esmee van den Bossche; Jacob Ytsma; Jeroen A. D. M. de Roos; Oscar P. J. van Linden; Yvonne Grobben; Jeffrey J. Kooijman; Guido J. R. Zaman†

High-throughput fluorescence-based screening assay for indoleamine 2,3-dioxygenase 2 (IDO2)

EUROPEAN JOURNAL OF CANCER

IF7.1

2024-10-01

PREAI

Willemsen-Seegers, N.; van der Leeuw, S.; Ytsma, J.; Grobben, Y.; Zaman, G.

Characterization of cancer cell lines selected for resistance to growth factor receptor tyrosine kinase inhibitors and signal transduction therapies

EUROPEAN JOURNAL OF CANCER

IF7.1

2024-10-01

PREAI

Melis, J.; Kluitmans, D.; Wetemans, S.; Vodegel, D.; Bertran-Alamillo, J.; Molina-Villa, M. A.; Kooijman, J.; Zaman, G.

Dual TTK/PLK1 inhibition has potent anticancer activity in TNBC as monotherapy and in combination

FRONTIERS IN ONCOLOGY

IF3.3

2024-08-09

OAAI

Zanini, Elisa; Forster-Gross, Nicole; Bachmann, Felix; Bruengger, Adrian; Mcsheehy, Paul; Litherland, Karine; Burger, Karin; Groner, Anna C.; Roceri, Mila; Bury, Luc; Stieger, Martin; Willemsen-Seegers, Nicole; de Man, Jos; Vu-Pham, Diep; van Riel, Helma W. E.; Zaman, Guido J. R.; Buijsman, Rogier C.; Kellenberger, Laurenz; Lane, Heidi A.

The bacterial lysate OM-85 engages Toll-like receptors 2 and 4 triggering an immunomodulatory gene signature in human myeloid cells

MUCOSAL IMMUNOLOGY

IF7.6

2024-06-01

OAAI

Khameneh, Hanif J.; Bolis, Marco; Ventura, Pedro M. O.; Cassanmagnago, Giada A.; Fischer, Berenice A.; Zenobi, Alessandro; Guerra, Jessica; Buzzago, Irene; Bernasconi, Maurizio; Zaman, Guido J. R.; Rinaldi, Andrea; Moro, Simone G.; Sallusto, Federica; Baulier, Edouard; Pasquali, Christian; Guarda, Greta

Screening of small-molecule MAPK pathway inhibitors on a panel of 130 human cancer cell lines identifies determinants of response in RAS-mutant subgroups

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Kooijman, Jeffrey J.; Al Koerdi, Awan; Kluitmans, Daphne J.; van den Bossche, Esmee; Dylus, Jelle; de Roos, Jeroen A.; Melis, Janneke J.; Zaman, Guido J.

Synergistic combinations and tissue type-specificity of compounds targeting components of the DNA damage response pathway in 2D culture and 3D spheroid cell viability assays

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Melis, Janneke J.; Kluitmans, Daphne J.; Kooijman, Jeffrey J.; Dylus, Jelle; Wetemans, Sabine; Geerdink-Datema, Suzan; de Roos, Jeroen A.; Grobben, Yvonne; Zaman, Guido J.

Comprehensive cell line profiling of monomer- and dimer-selective small molecule RAF inhibitors uncovers determinants of cellular responses

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Kooijman, Jeffrey J.; Al Koerdi, Awan; van der Leeuw, Sjoerd B.; Kluitmans, Daphne J.; van den Bossche, Esmee; Dylus, Jelle; de Roos, Jeroen A.; Melis, Janneke J.; Willemsen-Seegers, Nicole; Zaman, Guido J.

Characterization of fourth-generation EGFR inhibitors in binding experiments with C797S mutant EGFR and cell-based assays with osimertinib- resistant non-small cell lung cancer cell lines

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Melis, Janneke J.; Kevenaar, Kirsten; Kooijman, Jeffrey J.; Grobben, Yvonne; Ytsma, Jacob; Bertran-Alamillo, Jordi; Molina-Vila, Miguel-Angel; Willemsen-Seegers, Nicole; Zaman, Guido J.

Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

NATURE COMMUNICATIONS

IF15.7

2024-01-16

OAAI

Nishiguchi, Gisele; Mascibroda, Lauren G.; Young, Sarah M.; Caine, Elizabeth A.; Abdelhamed, Sherif; Kooijman, Jeffrey J.; Miller, Darcie J.; Das, Sourav; McGowan, Kevin; Mayasundari, Anand; Shi, Zhe; Barajas, Juan M.; Hiltenbrand, Ryan; Aggarwal, Anup; Chang, Yunchao; Mishra, Vibhor; Narina, Shilpa; Thomas, Melvin; Loughran, Allister J.; Kalathur, Ravi; Yu, Kaiwen; Zhou, Suiping; Wang, Xusheng; High, Anthony A.; Peng, Junmin; Pruett-Miller, Shondra M.; Daniels, Danette L.; Urh, Marjeta; Shelat, Anang A.; Mullighan, Charles G.; Riching, Kristin M.; Zaman, Guido J. R.; Fischer, Marcus; Klco, Jeffery M.; Rankovic, Zoran

Sensitivity and resistance mechanisms of human cancer cell lines treated with PARP, POL?, and ATR inhibitor combinations in 2D and 3D spheroid cell viability assays

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Melis, Janneke J. T. M.; Kooijman, Jeffrey; Wetemans, Sabine; Geerdink-Datema, Suzan; Dylus, Jelle; de Roos, Jeroen A. D. M.; van Riel, Wilhelmina E.; Zaman, Guido J. R.

Large-scale cell line profiling of small molecule MAPK pathway inhibitors identifies important differences between therapeutics acting on the same biochemical target

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Kooijman, Jeffrey J.; Al Koerdi, Awan; van Riel, Wilhelmina E.; van den Bossche, Esmee; Dylus, Jelle; de Roos, Jeroen A. D. M.; Melis, Janneke J. T. M.; Zaman, Guido J. R.

Dynamics of ligand-induced epidermal growth factor receptor internalization in cancer cell lines

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Smeets, Mandy W.; Smits, Eef F.; Melis, Janneke J.; Pappaioannou, Dimitri; Zaman, Guido J.

Comparative biochemical kinase activity analysis identifies rivoceranib as the most selective VEGFR-2 inhibitor compared with other TKIs with known activity against VEGFR-2

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Jang, Seong; Strickland, Bill; Finis, Lynda; Koojiman, Jeffrey J.; Melis, Janneke J.; Zaman, Guido J.; Tornout, Jan V.

IL4I1, IDO1 and other amino acid-metabolizing enzymes in high-grade serous ovarian cancer

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Grobben, Yvonne; Den Ouden, Judith E.; Aguado, Cristina; Van Altena, Anne M.; Kraneveld, Aletta D.; Zaman, Guido J.

Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020

FRONTIERS IN ONCOLOGY

IF3.3

2022-09-14

OAAI

Kooijman, Jeffrey J.; van Riel, Wilhelmina E.; Dylus, Jelle; Prinsen, Martine B. W.; Grobben, Yvonne; de Bitter, Tessa J. J.; van Doornmalen, Antoon M.; Melis, Janneke J. T. M.; Uitdehaag, Joost C. M.; Narumi, Yugo; Kawase, Yusuke; de Roos, Jeroen A. D. M.; Willemsen-Seegers, Nicole; Zaman, Guido J. R.

Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies

NATURE COMMUNICATIONS

IF15.7

2022-02-25

OAAI

Cordo, Valentina; Meijer, Mariska T.; Hagelaar, Rico; de Goeij-de Haas, Richard R.; Poort, Vera M.; Henneman, Alex A.; Piersma, Sander R.; Pham, Thang, V; Oshima, Koichi; Ferrando, Adolfo A.; Zaman, Guido J. R.; Jimenez, Connie R.; Meijerink, Jules P. P.

MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance

LEUKEMIA

IF13.4

2021-05-18

PREAI

van der Zwet, Jordy C. G.; Buijs-Gladdines, Jessica G. C. A. M.; Cordo', Valentina; Debets, Donna O.; Smits, Willem K.; Chen, Zhongli; Dylus, Jelle; Zaman, Guido J. R.; Altelaar, Maarten; Oshima, Koichi; Bornhauser, Beat; Bourquin, Jean-Pierre; Cools, Jan; Ferrando, Adolfo A.; Vormoor, Josef; Pieters, Rob; Vormoor, Britta; Meijerink, Jules P. P.

Pharmacological validation of TDO as a target for Parkinson's disease

FEBS JOURNAL

IF4.2

2021-02-18

OAAI

Perez-Pardo, Paula; Grobben, Yvonne; Willemsen-Seegers, Nicole; Hartog, Mitch; Tutone, Michaela; Muller, Michelle; Adolfs, Youri; Pasterkamp, Ronald Jeroen; Vu-Pham, Diep; van Doornmalen, Antoon M.; van Cauter, Freek; de Wit, Joeri; Sterrenburg, Jan Gerard; Uitdehaag, Joost C. M.; de Man, Jos; Buijsman, Rogier C.; Zaman, Guido J. R.; Kraneveld, Aletta D.

研究方向