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Immunomodulatory gene networks predict treatment response and survival to de-escalated, anthracycline-free neoadjuvant chemotherapy in triple-negative breast cancer in the WSG-ADAPT-TN trial 免疫调节基因网络预测在WSG-ADAPT-TN试验中，三阴性乳腺癌对降级、无蒽环类的新辅助化疗的治疗反应和生存情况。 Korbie, Darren; Stirzaker, Clare; Gluz, Oleg; zu Eulenburg, Christine; Nitz, Ulrike; Christgen, Matthias; Kuemmel, Sherko; Grischke, Eva-Maria; Forstbauer, Helmut; Braun, Michael; Warm, Mathias; Hackmann, John; Uleer, Christoph; Aktas, Bahriye; Schumacher, Claudia; Wuerstlein, Rachel; Pelz, Enrico; Kreipe, Hans Heinrich; Clark, Susan J.; Trau, Matt; Graeser, Monika; Harbeck, Nadia 分享 收藏
UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation Tiedemann, Rochelle L.; Hrit, Joel; Du, Qian; Wiseman, Ashley K.; Eden, Hope E.; Dickson, Bradley M.; Kong, Xiangqian; Chomiak, Alison A.; Vaughan, Robert M.; Tibben, Bailey M.; Hebert, Jakob M.; David, Yael; Zhou, Wanding; Baylin, Stephen B.; Jones, Peter A.; Clark, Susan J.; Rothbart, Scott B. 分享 收藏
Irreversible electroporation of localised prostate cancer downregulates immune suppression and induces systemic anti-tumour T-cell activation - IRE-IMMUNO study Geboers, Bart; Scheltema, Matthijs J.; Jung, Jason; Bakker, Joyce; Timmer, Florentine E. F.; Cerutti, Xanthe; Katelaris, Athos; Doan, Paul; Gondoputro, William; Blazevski, Alexandar; Agrawal, Shikha; Matthews, Jayne; Haynes, Anne-Maree; Robertson, Tim; Thompson, James E.; Meijerink, Martijn R.; Clark, Susan J.; de Gruijl, Tanja D.; Stricker, Phillip D. 分享 收藏
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PPAR gamma acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding Tian, LIfeng; Jiao, Xuanmao; Wang, Chenguang; Ertel, Adam; Soccio, Raymond; Chen, Eric R.; Gyorffy, Balazs; Di Sante, Gabriele; Zhong, Zhijiu; Addya, Sankar; Mccue, Peter A.; Kossenkov, Andrew V.; Achinger-Kawecka, Joanna; Clark, Susan; Pestell, Richard G. 分享 收藏
Characterisation and reproducibility of the HumanMethylationEPIC v2.0 BeadChip for DNA methylation profiling Peters, Timothy J.; Meyer, Braydon; Ryan, Lauren; Achinger-Kawecka, Joanna; Song, Jenny; Campbell, Elyssa M.; Qu, Wenjia; Nair, Shalima; Loi-Luu, Phuc; Stricker, Phillip; Lim, Elgene; Stirzaker, Clare; Clark, Susan J.; Pidsley, Ruth 分享 收藏
Detailed DNA methylation characterisation of phyllodes tumours identifies a signature of malignancy and distinguishes phyllodes from metaplastic breast carcinoma 叶状肿瘤的详细DNA甲基化表征可识别恶性肿瘤的特征，并将叶状体与化生性乳腺癌区分开 Meyer, Braydon; Stirzaker, Clare; Ramkomuth, Sonny; Harvey, Kate; Chan, Belinda; Lee, Cheok Soon; Karim, Rooshdiya; Deng, Niantao; Avery-Kiejda, Kelly A.; Scott, Rodney J.; Lakhani, Sunil; Fox, Stephen; Robbins, Elizabeth; Shin, Joo-Shik; Beith, Jane; Gill, Anthony; Sioson, Loretta; Chan, Charles; Krishnaswamy, Mrudula; Cooper, Caroline; Warrier, Sanjay; Mak, Cindy; Rasko, John E. J.; Bailey, Charles G.; Swarbrick, Alexander; Clark, Susan J.; O'Toole, Sandra; Pidsley, Ruth 分享 收藏
The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer Achinger-Kawecka, Joanna; Stirzaker, Clare; Portman, Neil; Campbell, Elyssa; Chia, Kee-Ming; Du, Qian; Laven-Law, Geraldine; Nair, Shalima S.; Yong, Aliza; Wilkinson, Ashleigh; Clifton, Samuel; Milioli, Heloisa H.; Alexandrou, Sarah; Caldon, C. Elizabeth; Song, Jenny; Khoury, Amanda; Meyer, Braydon; Chen, Wenhan; Pidsley, Ruth; Qu, Wenjia; Gee, Julia M. W.; Schmitt, Anthony; Wong, Emily S.; Hickey, Theresa E.; Lim, Elgene; Clark, Susan J. 分享 收藏
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer 一种一流的泛赖氨酰氧化酶抑制剂可削弱胰腺癌的基质重塑并增强吉西他滨反应和生存率 Chitty, Jessica L.; Yam, Michelle; Perryman, Lara; Parker, Amelia L.; Skhinas, Joanna N.; Setargew, Yordanos F. I.; Mok, Ellie T. Y.; Tran, Emmi; Grant, Rhiannon D.; Latham, Sharissa L.; Pereira, Brooke A.; Ritchie, Shona C.; Murphy, Kendelle J.; Trpceski, Michael; Findlay, Alison D.; Melenec, Pauline; Filipe, Elysse C.; Nadalini, Audrey; Velayuthar, Sipiththa; Major, Gretel; Wyllie, Kaitlin; Papanicolaou, Michael; Ratnaseelan, Shivanjali; Phillips, Phoebe A.; Sharbeen, George; Youkhana, Janet; Russo, Alice; Blackwell, Antonia; Hastings, Jordan F.; Lucas, Morghan C.; Chambers, Cecilia R.; Reed, Daniel A.; Stoehr, Janett; Vennin, Claire; Pidsley, Ruth; Zaratzian, Anaiis; Da Silva, Andrew M.; Tayao, Michael; Charlton, Brett; Herrmann, David; Nobis, Max; Clark, Susan J.; Biankin, Andrew V.; Johns, Amber L.; Croucher, David R.; Nagrial, Adnan; Gill, Anthony J.; Grimmond, Sean M.; Pajic, Marina; Timpson, Paul; Jarolimek, Wolfgang; Cox, Thomas R. 分享 收藏
Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality 全面的甲基化测序揭示了前列腺癌死亡率的预后表观遗传生物标志物 Pidsley, Ruth; Lam, Dilys; Qu, Wenjia; Peters, Timothy J.; Phuc-Loi Luu; Korbie, Darren; Stirzaker, Clare; Daly, Roger J.; Stricker, Phillip; Kench, James G.; Horvath, Lisa G.; Clark, Susan J. 分享 收藏
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GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol) Conduit, Ciara; Mak, Blossom; Qu, Wenjia; Di Lulio, Juliana; Burder, Ronan; Bressel, Matthias; Cusick, Thomas; Dhillon, Haryana M.; Lourenco, Richard De Abreu; Underhill, Craig; Torres, Javier; Crumbaker, Megan; Honeyball, Florian; Linton, Anthony; Allen, Ray; Davis, Ian D.; Clark, Susan J.; Horvath, Lisa G.; Mahon, Kate L. 分享 收藏
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Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer DNA甲基化生物标志物的鉴定，可预测三阴性乳腺癌对新辅助化疗的反应 Meyer, Braydon; Clifton, Samuel; Locke, Warwick; Luu, Phuc-Loi; Du, Qian; Lam, Dilys; Armstrong, Nicola J.; Kumar, Beena; Deng, Niantao; Harvey, Kate; Swarbrick, Alex; Ganju, Vinod; Clark, Susan J.; Pidsley, Ruth; Stirzaker, Clare 分享 收藏
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity 需要DNA甲基化来维持DNA复制时间的精确性和3D基因组组织的完整性 Du, Qian; Smith, Grady C.; Phuc Loi Luu; Ferguson, James M.; Armstrong, Nicola J.; Caldon, C. Elizabeth; Campbell, Elyssa M.; Nair, Shalima S.; Zotenko, Elena; Gould, Cathryn M.; Buckley, Michael; Chia, Kee-Ming; Portman, Neil; Lim, Elgene; Kaczorowski, Dominik; Chan, Chia-Ling; Barton, Kirston; Deveson, Ira W.; Smith, Martin A.; Powell, Joseph E.; Skvortsova, Ksenia; Stirzaker, Clare; Achinger-Kawecka, Joanna; Clark, Susan J. 分享 收藏
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