Paul A.M. Michels - Publications, H-index & Citations

Paul A.M. Michels

University of Edinburgh

70H指数

377论文数

2.1W被引数

收录论文 83

发表时间

MicroRNAs during Echinococcus spp. infection: a comprehensive systematic review and implications for diagnosis and therapy 棘球属感染期间的微小RNA：一项全面的系统综述及其在诊断和治疗中的意义

Parasites & Vectors

IF3.5

2026-07-23

OAAI

Maura Rojas-Pirela; Diego Andrade-Alviárez; Verónica Rojas; Christian Castillo; Alejandro Prieto-Rojas; Vanessa Rueda-Cala; Cristina Carbonell; Daniel Salete-Granado; Candy Pérez; María A. Pérez-Nieto; Paul A. M. Michels; Wilfredo Quiñones; Miguel Marcos; Ulrike Kemmerling

Cryptic peroxisomal targeting determinants in protistan glycolytic enzymes suggest a “how” for glycosome evolution 原生生物糖酵解酶中隐藏的过氧化物酶体靶向决定因子为糖原体进化提供了“如何”的解释

Genetics

IF5.1

2026-07-18

OAAI

Asma Belbelazi; Jane Harmer; Andrew S Kennard; Emily M Larkin; Victoria L Constantine; Lillian K Fritz-Laylin; Martin Carr; Paul A M Michels; Michael L Ginger; null; null

Characterization of GH18 chitinase in Leishmania braziliensis: expression, structural insights, and implications for vaccine and therapeutic development 巴西利什曼原虫中GH18几丁质酶的表征：表达、结构见解及其在疫苗和治疗方法开发中的意义

Biological Research

IF4.6

2026-04-16

OAAI

Maura Rojas-Pirela; Marirene Chacón-Arnaude; Cristóbal Lárez-Velásquez; María Verónica Rojas; Constanza Cardenas; Ana J. Cáceres; Luis-Antonio Corchete; Diego Andrade-Alviárez; Luis A. Prieto-Rojas; Daniel Salete-Granado; María Á. Pérez-Nieto; Wilfredo Quiñones; Paul A. M. Michels; Miguel Marcos

Dysregulated Expression of Canonical and Non-Canonical Glycolytic Enzyme Isoforms in Peripheral Blood from Subjects with Alcohol Use Disorder and from Individuals with Acute Alcohol Consumption 酒精使用障碍患者和急性饮酒个体外周血中经典和非经典糖酵解酶异构体的失调表达

Antioxidants 2025, Vol. 14, Page 1143

IF6.6

2025-09-22

OAAI

Maura Rojas-Pirela; Daniel Salete-Granado; Diego Andrade-Alviárez; Alejandro Prieto-Rojas; Cristina Rodríguez; María-Lourdes Aguilar-Sánchez; David Puertas-Miranda; María-Ángeles Pérez-Nieto; Vanessa Rueda-Cala; Candy Pérez; Wilfredo Quiñones; Paul A. M. Michels; Ángeles Almeida; Miguel Marcos

Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei 3-O-p-(Z/E)-coumaroyltormentic acid处理后的锥虫属布氏锥虫的代谢组学研究

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

IF3.4

2025-06-10

OAAI

Lúcia Mamede; Fanta Fall; Madeline Vast; Kristelle Hughes; Giorgia Martelli; Francesco Caligiore; Bernadette Govaerts; Paul A.M. Michels; Michel Frédérich; Joëlle Quetin-Leclercq

The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei operates also in the gluconeogenic direction 锥虫Trypanosoma brucei的糖酵解体ATP依赖性磷酸果糖激酶也作用于糖异生方向。

PLOS BIOLOGY

IF7.2

2025-05-16

OAAI

Plazolles, Nicolas; Kulyk, Hanna; Cahoreau, Edern; Biran, Marc; Wargnies, Marion; Pineda, Erika; El Kadri, Mohammad; Rimoldi, Aline; Herve, Perrine; Asencio, Corinne; Riviere, Loic; Michels, Paul A. M.; Inaoka, Daniel; Tetaud, Emmanuel; Portais, Jean-Charles; Bringaud, Frederic

Insights into biofilm-mediated mechanisms driving last-resort antibiotic resistance in clinical ESKAPE pathogens 对临床ESKAPE病原体中生物膜介导的驱动最后手段抗生素耐药性机制的见解

Critical Reviews in Microbiology

IF5.1

2025-03-17

PREAI

Christina Shook Cheng Chong; Yin Yin Lau; Paul A. M. Michels; Crystale Siew Ying Lim

First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis 苏拉明治疗的布氏锥虫的第一个全面的非靶向代谢组学研究: 从多因素数据建模到功能分析的综合数据分析工作流程

METABOLOMICS

IF3.3

2024-02-23

PREAI

Fall, Fanta; Mamede, Lucia; Vast, Madeline; De Tullio, Pascal; Hayette, Marie-Pierre; Michels, Paul A. M.; Frederich, Michel; Govaerts, Bernadette; Quetin-Leclercq, Joelle

How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell (vol 19, e1011522, 2023)

PLOS PATHOGENS

IF4.9

2023-08-30

OAAI

Nascimento, Janaina F.; Souza, Rodolpho O. O.; Alencar, Mayke B.; Marsiccobetre, Sabrina; Murillo, Ana M.; Damasceno, Flavia S.; Girard, Richard B. M. M.; Marchese, Leticia; Luevano-Martinez, Luis A.; Achjian, Renan W.; Haanstra, Jurgen R.; Michels, Paul A. M.; Silber, Ariel M.

How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell 建立一个锥虫需要多少 (ATP)？维持和复制血液形式的布氏锥虫细胞所需的ATP量的理论研究

PLOS PATHOGENS

IF4.9

2023-07-27

OAAI

Evolution: 'Millefoglie' origin of mitochondrial cristae 进化: 线粒体cristae的 “millefoglie” 起源

CURRENT BIOLOGY

IF7.5

2023-03-01

OAAI

Michels, Paul A. M.; Ginger, Michael L.

Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery 布氏锥虫: 用于细胞代谢分析和药物发现的代谢组学

METABOLOMICS

IF3.3

2022-03-19

OAAI

Fall, Fanta; Mamede, Lucia; Schioppa, Laura; Ledoux, Allison; De Tullio, Pascal; Michels, Paul; Frederich, Michel; Quetin-Leclercq, Joelle

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice 速效变构磷酸果糖激酶抑制剂阻断锥虫糖酵解并治愈小鼠急性非洲锥虫病

NATURE COMMUNICATIONS

IF15.7

2021-02-16

OAAI

McNae, Iain W.; Kinkead, James; Malik, Divya; Yen, Li-Hsuan; Walker, Martin K.; Swain, Chris; Webster, Scott P.; Gray, Nick; Fernandes, Peter M.; Myburgh, Elmarie; Blackburn, Elizabeth A.; Ritchie, Ryan; Austin, Carol; Wear, Martin A.; Highton, Adrian J.; Keats, Andrew J.; Vong, Antonio; Dornan, Jacqueline; Mottram, Jeremy C.; Michels, Paul A. M.; Pettit, Simon; Walkinshaw, Malcolm D.

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches 三种人类磷酸果糖激酶之间的生化和转录水平差异显示了特定代谢生态位的每种同工型的优化

BIOCHEMICAL JOURNAL

IF4.3

2020-11-27

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain; Michels, Paul A. M.; Walkinshaw, Malcolm D.

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis 锥虫和利什曼原虫磷酸果糖激酶的动力学和结构研究显示出进化差异，并将AMP确定为调节糖酵解与糖异生的开关

FEBS JOURNAL

IF4.2

2020-01-08

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain W.; Vasquez-Valdivieso, Monserrat; Wear, Martin A.; Michels, Paul A. M.; Walkinshaw, Malcolm D.

Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling 通过代谢控制分析和动力学模型选择克氏锥虫代谢的药物靶标

CURRENT MEDICINAL CHEMISTRY

IF3.5

2019-12-13

PREAI

Saavedra, Emma; Gonzalez-Chavez, Zabdi; Moreno-Sanchez, Rafael; Michels, Paul A. M.

Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei 发现对布氏锥虫的甘油激酶和替代氧化酶具有双重抑制作用的锥虫香豆素

FASEB JOURNAL

IF4.2

2019-09-16

OAAI

Balogun, Emmanuel Oluwadare; Inaoka, Daniel Ken; Shiba, Tomoo; Tsuge, Chiaki; May, Benjamin; Sato, Tomohiro; Kido, Yasutoshi; Nara, Takeshi; Aoki, Takashi; Honma, Teruki; Tanaka, Akiko; Inoue, Masayuki; Matsuoka, Shigeru; Michels, Paul A. M.; Watanabe, Yoh-Ichi; Moore, Anthony L.; Harada, Shigeharu; Kita, Kiyoshi

Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity Γ-谷氨酰半胱氨酸合成酶和tryparoduxin 1对克氏锥虫的抗氧化系统具有高度控制作用，有助于耐药性和感染性

REDOX BIOLOGY

IF11.9

2019-09-01

OAAI

Gonzalez-Chavez, Zabdi; Vazquez, Citlali; Mejia-Tlachi, Marlen; Marquez-Duenas, Claudia; Manning-Cela, Rebeca; Encalada, Rusely; Rodriguez-Enriquez, Sara; Michels, Paul A. M.; Moreno-Sanchez, Rafael; Saavedra, Emma

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction 逆转反应的人和锥虫磷酸果糖激酶的动力学特征

BIOCHEMICAL JOURNAL

IF4.3

2019-01-18

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain W.; Bringaud, Frederic; Michels, Paul A. M.; Walkinshaw, Malcolm D.

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation 半胱氨酸氧化和S-亚硝化对丙酮酸激酶M2的氧化还原调节

BIOCHEMICAL JOURNAL

IF4.3

2018-10-31

OAAI

Mitchell, Alice Rose; Yuan, Meng; Morgan, Hugh P.; McNae, Iain W.; Blackburn, Elizabeth A.; Le Bihan, Thierry; Homem, Rafael A.; Yu, Manda; Loake, Gary J.; Michels, Paul A.; Wear, Martin A.; Walkinshaw, Malcolm D.

研究方向