Richard D. Unwin - Publications, H-index & Citations

Richard D. Unwin

University of Manchester

39H指数

189论文数

5.0K被引数

收录论文 67

发表时间

Roles of astrocytic Connexin 43 gap junctional deficit in alpha-synucleinopathy and inflammation relevant to Parkinson’s 星形胶质细胞连接蛋白43间隙连接缺陷在α-突触核蛋白病和与帕金森病相关的炎症中的作用

Experimental Neurology

IF4.2

2026-06-26

OAAI

Nataly Hastings; Saifur Rahman; Wei-Li Kuan; Maha Alfaidi; Sarah Fox; Nadia A. Erkamp; Ewa Andrzejewska; Michael Whitehead; Aleksandr Zakirov; Richard D. Unwin; Koby Baranes; Ronny Schmidt; Anna Oliinyk; Donya Aref; Jonathan Brotchie; Tuomas P.J. Knowles; George G. Malliaras; Mark R.N. Kotter

Blood proteomics: insights from public data 血液蛋白质组学：公共数据中的见解

Genome Biology

IF9.4

2026-03-12

OAAI

Asier Larrea-Sebal; Chengxin Dai; Alejandro J. Brenes; Kathrin Korff; Benjamin A. Neely; Philipp E. Geyer; Laura F. Dagley; Richard D. Unwin; Alexandra Naba; Michael J. MacCoss; Tiannan Guo; Eric W. Deutsch; Cesar Martin; Jochen M. Schwenk; Yasset Perez-Riverol

EVC protein regulates Sonic hedgehog signaling during human intervertebral disc development and degeneration EVC蛋白在人椎间盘发育和退变过程中调控Sonic hedgehog信号通路

iScience

IF4.1

2025-12-04

OAAI

Zihan Wu; Lizzy Shaw; Christabel T. Dube; Andra-Maria Ionescu; Tengyang Qiu; Anna L. Tierney; Pauline Baird; Sonal Patel; Leo A.H. Zeef; Lindsay J. Birchall; Rachel E. Jennings; Neil A. Hanley; Richard D. Unwin; Judith A. Hoyland; Stephen M. Richardson

CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival CLN7蛋白在自噬溶酶体和应激小体之间的界面发挥作用，以促进细胞存活。

Cell Death & Disease

IF9.6

2025-10-31

OAAI

Aseel Sharaireh; Marta Guevara-Ferrer; Anna M. Ludlaim; Jonathan D. Humphries; Alexander M. Phillips; Andrew W. Dowsey; Zehan Zhang; John R. Counsell; Richard D. Unwin; Sara E. Mole; Ahad A. Rahim; Tristan R. McKay

CTx001 for geographic atrophy: a gene therapy expressing soluble, truncated complement receptor 1 (mini-CR1)CTx001用于地图状萎缩：一种表达可溶性截短补体受体1（mini-CR1）的基因疗法

Ophthalmology Science

IF4.6

2025-10-21

OAAI

Sonika Rathi; Athanasios Didangelos; Sofiya Pisarenka; Rachel Green; Peter Emery-Billcliff; Nakul Patel; Pamela Whalley; Parisa Zamira; Viranga Tilakaratna; Ewa Szula; Rafiq Hasan; Mustafa M. Munye; Richard D. Unwin; Paul N. Bishop; Dennis Keefe; Simon J. Clark

Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation

NAR CANCER

IF3.2

2024-07-16

OAAI

Coulson-Gilmer, Camilla; Littler, Samantha; Barnes, Bethany M.; Brady, Rosie M.; Anagho, Holda A.; Pillay, Nisha; Dey, Malini; Macmorland, William; Bronder, Daniel; Nelson, Louisa; Tighe, Anthony; Lin, Wei-Hsiang; Morgan, Robert D.; Unwin, Richard D.; Nielsen, Michael L.; Mcgrail, Joanne C.; Taylor, Stephen S.

Extensive multiregional urea elevations in a case-control study of vascular dementia point toward a novel shared mechanism of disease amongst the age-related dementias 在血管性痴呆的病例对照研究中，广泛的多区域尿素升高指向与年龄相关的痴呆症中新的共享疾病机制

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2023-07-13

OAAI

Philbert, Sasha A.; Xu, Jingshu; Scholefield, Melissa; Patassini, Stefano; Church, Stephanie J.; Unwin, Richard D.; Roncaroli, Federico; Cooper, Garth J. S.

Multi-regional alterations in glucose and purine metabolic pathways in the Parkinson's disease dementia brain

NPJ PARKINSONS DISEASE

IF8.2

2023-04-20

OAAI

Scholefield, Melissa; Church, Stephanie J.; Taylor, George; Knight, David; Unwin, Richard D.; Cooper, Garth J. S.

Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial 补体和凝血途径蛋白与首发精神病治疗反应的关系: 优化临床试验的纵向分析

SCHIZOPHRENIA BULLETIN

IF4.8

2023-03-14

OAAI

Susai, Subash Raj; Foecking, Melanie; Mongan, David; Heurich, Meike; Coutts, Fiona; Egerton, Alice; Whetton, Tony; Winter-van Rossum, Inge; Unwin, Richard D.; Pollak, Thomas A.; Weiser, Mark; Leboyer, Marion; Rujescu, Dan; Byrne, Jonah F.; Gifford, George W.; Dazzan, Paola; Koutsouleris, Nikolaos; Kahn, Rene S.; Cotter, David R.; McGuire, Philip

Elevated hippocampal copper in cases of type 2 diabetes

EBIOMEDICINE

IF10.8

2022-12-01

OAAI

Philbert, Sasha A.; Schoenberger, Sarah J.; Xu, Jingshu; Church, Stephanie J.; Unwin, Richard D.; Cooper, Garth J. S.

Levels of soluble complement regulators predict severity of COVID-19 symptoms

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-10-18

OAAI

Tierney, Anna L.; Alali, Wajd Mohammed; Scott, Thomas; Rees-Unwin, Karen S.; Clark, Simon J.; Unwin, Richard D.

Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis 血管性痴呆的泛脑钠升高: 脑钠稳态紊乱的证据

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2022-07-18

OAAI

Philbert, Sasha A.; Xu, Jingshu; Church, Stephanie J.; Unwin, Richard D.; Roncaroli, Federico; Cooper, Garth J. S.

Coenzyme A-Dependent Tricarboxylic Acid Cycle Enzymes Are Decreased in Alzheimer's Disease Consistent With Cerebral Pantothenate Deficiency

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2022-06-10

OAAI

Sang, Crystal; Philbert, Sasha A.; Hartland, Danielle; Unwin, Richard. D.; Dowsey, Andrew W.; Xu, Jingshu; Cooper, Garth J. S.

Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-05-13

OAAI

Mcharg, Selina; Booth, Laura; Perveen, Rahat; Garcia, Isabel Riba; Brace, Nicole; Bayatti, Nadhim; Sergouniotis, Panagiotis, I; Phillips, Alexander M.; Day, Anthony J.; Black, Graeme C. M.; Clark, Simon J.; Dowsey, Andrew W.; Unwin, Richard D.; Bishop, Paul N.

Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization

EXPERIMENTAL EYE RESEARCH

IF2.7

2022-02-01

OAAI

Klaska, Izabela P.; White, Anne; Villacampa, Pilar; Hoke, Justin; Abelleira-Hervas, Laura; Maswood, Ryea N.; Ali, Robin R.; Bunce, Catey; Unwin, Richard D.; Cooper, Garth J. S.; Bishop, Paul N.; Bainbridge, James W.

Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential Na+/K+-ATPase Dysfunction in Vascular Dementia

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2022-01-28

OAAI

Philbert, Sasha A.; Xu, Jingshu; Scholefield, Melissa; Church, Stephanie J.; Unwin, Richard D.; Cooper, Garth J. S.

Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson's Disease Dementia 人脑中组织尿素的严重和区域性广泛增加代表了帕金森氏病痴呆致病潜力的新发现

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2021-10-22

OAAI

Scholefield, Melissa; Church, Stephanie J.; Xu, Jingshu; Patassini, Stefano; Roncaroli, Federico; Hooper, Nigel M.; Unwin, Richard D.; Cooper, Garth J. S.

Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson's Disease Dementia

METABOLITES

IF3.7

2021-08-25

OAAI

Scholefield, Melissa; Church, Stephanie J.; Xu, Jingshu; Patassini, Stefano; Hooper, Nigel M.; Unwin, Richard D.; Cooper, Garth J. S.

Adipocyte NR1D1 dictates adipose tissue expansion during obesity 脂肪细胞NR1D1决定肥胖期间脂肪组织的扩张

ELIFE

IF0

2021-08-05

OAAI

Hunter, Ann Louise; Pelekanou, Charlotte E.; Barron, Nichola J.; Northeast, Rebecca C.; Grudzien, Magdalena; Adamson, Antony D.; Downton, Polly; Cornfield, Thomas; Cunningham, Peter S.; Billaud, Jean-Noel; Hodson, Leanne; Loudon, Andrew S., I; Unwin, Richard D.; Iqbal, Mudassar; Ray, David W.; Bechtold, David A.

Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2021-08-01

OAAI

Cipriani, Valentina; Tierney, Anna; Griffiths, John R.; Zuber, Verena; Sergouniotis, Panagiotis, I; Yates, John R. W.; Moore, Anthony T.; Bishop, Paul N.; Clark, Simon J.; Unwin, Richard D.

研究方向