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黄

黄昊 (Hao Huang)

peking university

H指数:25

被引数:2,925

个人简介

任职于北京大学深圳研究生院，特聘研究员。1995年至1999年在四川大学获生物学学士学位，1999年至2002年在清华大学获分析化学硕士学位，2006年至2011年在加拿大卡尔加里大学获生物化学博士学位。2011年至2015年在加拿大多伦多西奈山医院从事博士后研究，2015年至2016年在英国剑桥Astex制药公司任高级研究员，从事基于片段的抗癌药物开发。2017年获拜耳-北京大学研究员称号，2014年获加拿大卫生与健康研究院博士后基金，2008年获加拿大阿尔伯特省医学研究基金会博士生奖学金。

教育背景

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工作经历

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荣誉奖项

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The seven human coronavirus main proteases exhibit differential modulation of NF-κB suppression via TAB1 cleavage

七种人类冠状病毒主要蛋白酶通过TAB1切割表现出对NF-κB抑制的差异调节

Communications Biology

IF5.1

2026-05-210

OAAI

ISGylation prevents autophagic degradation of STING and promotes antitumor immunity in lung cancer

ISGylation可防止STING的自噬性降解，并促进肺癌的抗肿瘤免疫。

Cell Death & Disease

IF9.6

2026-02-270

OAAI

Europium-mediated fluorescence engineering for organic dyes to improve efficiency and ultraviolet stability of silicon heterojunction solar cells

铕介导的有机染料荧光工程以提升硅异质结太阳能电池的效率和紫外稳定性

Solar Energy Materials and Solar Cells

IF6.3

2025-10-280

PRE

Ligand Engineering Enhances Fluorescence Properties of Eu-Based Complexes for Efficiency Enhancement and UV Stability in Silicon Heterojunction Solar Cells

配体工程增强Eu基配合物的荧光性能，以提高硅异质结太阳能电池的效率及UV稳定性

Advanced Optical Materials

IF7.2

2025-06-300

PRE

Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O

E2/E3杂合酶UBE2O生化机制的构效关系研究

IF4.3

2025-02-012

PRE

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark (Expression of Concern of 10.1038/NATURE12318)

53BP1 是DNA损伤诱导的H2A赖氨酸15泛素化修饰的识别蛋白（《自然》杂志文章10.1038/NATURE12318的"Expression of Concern"）。

IF48.5

2025-01-290

PRE

USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

USP7去泛素化KRAS并促进非小细胞肺癌

IF6.9

2024-11-010

OAAI

The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING

SCIENCE SIGNALING

IF6.6

2023-05-0225

OA

The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression

SCIENCE SIGNALING

IF6.6

2023-05-027

OA

In Situ Generating YVO4:Eu3+,Bi3+ Downshifting Phosphors in SiO2 Antireflection Coating for Efficiency Enhancement and Ultraviolet Stability of Silicon Solar Cells

IF4.7

2023-04-286

PRE

Targeting UBE2C for degradation by bioPROTACs based on bacterial E3 ligase

基于细菌E3连接酶的bioPROTACs靶向UBE2C降解

CHINESE CHEMICAL LETTERS

IF8.9

2023-04-016

PRE

Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-11-298

OA

The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

NATURE COMMUNICATIONS

IF15.7

2021-01-20215

OAAI

Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8

COMMUNICATIONS BIOLOGY

IF5.1

2020-12-1012

OAAI

A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-09-2120

OAAI

Sunitinib inhibits RNase L by destabilizing its active dimer conformation

BIOCHEMICAL JOURNAL

IF4.3

2020-09-1712

OA

Amino Acid Transporters in Plant Cells: A Brief Review

IF4.1

2020-07-3085

OAAI

Pretargeted Immuno-PET Based on Bioorthogonal Chemistry for Imaging EGFR Positive Colorectal Cancer

BIOCONJUGATE CHEMISTRY

IF3.9

2018-01-1828

PREAI

Genomic architecture of biomass heterosis in Arabidopsis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2017-07-1076

OAAI

Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation

IF3

2017-04-0311

OAAI

研究方向

结构生物学与药物开发开发化学小分子抗肿瘤抗病毒药物泛素化体系和激酶家族中的重要靶标蛋白基于结构的药物设计基于片段的药物开发方法药物化学生物学泛素蛋白酶体系统激酶家族信号传导细胞生物学抗癌药物开发靶点结构生物学和细胞生物学在药物开发上的有效结合。欢迎化学化工生物学药学

H 指数:6论文数:10被引数:460

H 指数:32论文数:196被引数:1.3万

H 指数:13论文数:58被引数:773

H 指数:72论文数:280被引数:2.1万

H 指数:8论文数:20被引数:514

H 指数:18论文数:39被引数:1,944

H 指数:21论文数:59被引数:2,008

H 指数:13论文数:37被引数:854

H 指数:8论文数:26被引数:524

H 指数:27论文数:152被引数:2,960