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D

David R. Spring

university of cambridge

67H指数
548论文数
2.0W被引数
收录论文 150
发表时间
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Diarylethene-Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation含二芳基乙烯的光开关类Tubulysins——设计、合成、生物学及结构评价
errEuropean Journal of Organic Chemistry
IF2.7
err2026-09-22
err0
errOAAI
errAnna Iampolska; Sergii Afonin; Oleg Babii; Mahri Park; Juan Estévez-Gallego; Michel O. Steinmetz; Andrea E. Prota; Anne S. Ulrich; David R. Spring; Igor V. Komarov
err分享
err收藏
Catalytic atroposelective macrocyclization for constructing dominant rotors in peptides催化非对映选择性大环化在构建肽类主导转子中的应用
errChem
IF19.6
err2026-09-17
err0
errOAAI
errLinwei Zeng; Yang (Daniel) Ou; Tianyi Yang; Alexander Rowley; Peter Rukovanský; Andrew D. Bond; Andrei K. Yudin; David R. Spring
err分享
err收藏
Frontispiece: Multicomponent Stapling of Glucagon-Like Peptide-1 Enables Receptor-Guided PROTAC Delivery插图：胰高血糖素样肽-1的多组分 Stapling 实现受体引导的PROTAC递送
errAngewandte Chemie-International Edition
IF16.9
err2026-08-28
err0
errOAAI
errJan L. Venne; Sona Krajcovicova; Graeme Davies; Hannah Bolt; Jefferson Revell; David R. Spring
err分享
err收藏
Recent advances in antibody–drug conjugates抗体药物偶联物的最新进展
errCurrent Opinion in Chemical Biology
IF6.1
err2026-07-16
err0
errOAAI
errJack D. Sydenham; Thomas Wharton; David R. Spring
err分享
err收藏
Peptide Marriages: Modular Assembly of Multi-Agonist Therapeutics肽联姻：多激动剂治疗药物的模块化组装
errChemistry – A European Journal
IF0
err2026-06-18
err0
errOAAI
errKristina A. Kostadinova; Jan L. Venne; Sona Krajcovicova; James Dodgson; Wouter F. J. Hogendorf; Thomas E. Nielsen; David Hymel; Hannah Bolt; Andie Collinson; Jason Day; Jefferson Revell; David R. Spring
err分享
err收藏
On-resin assembly of cysteine-reactive linkers for controlled site-selective antibody bioconjugation在树脂上组装半胱氨酸反应性连接剂以实现可控的位点选择性抗体生物缀合
errNature Protocols
IF16
err2026-06-09
err0
PREAI
errSona Krajcovicova; Thomas Wharton; David R. Spring
err分享
err收藏
Boosting Peptide Half-Life: Enabling Efficient Generation of Fc-Peptide Conjugates增强肽半衰期：实现Fc-肽缀合物的有效生成
errchem. sci.
IF0
err2026-05-29
err0
errOAAI
errMahri Park; Friederike M. Dannheim; Monika A. Papworth; Richard Kay; Elpida Tsonou; Daniel Trajkovski; Stephen J Walsh; Daniel Hovdal; Thomas Wharton; Anne-Chloe Nassoy; Jeremy Parker; David R Spring
err分享
err收藏
Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs靶向CK2蛋白质降解：基于CAM4066的PROTACs设计与合成
errBeilstein Journal of Organic Chemistry
IF2.1
err2026-04-22
err0
errOAAI
errDay-Riley, Sophie; Krajcovicova, Sona; Sokhal, Aryaman Raj; Venne, Jan L.; Brear, Paul; Hyvonen, Marko; Whitehurst, Benjamin C.; Carroll, Jason S.; Spring, David R.
err分享
err收藏
Bismuth Bicycles铋双环
errJournal of Peptide Science
IF1.8
err2026-03-01
err0
PREAI
errVoss, Saan; Sagar, Amin; Tiberghien, Arnaud; Hughes, Richard J. L.; Chen, Liuhong; Rioja, Inmaculada; Frigerio, Mark; Skynner, Michael J.; Spring, David R.
err分享
err收藏
MMP-Cleavable Linker Platform for Tumour-Responsive Homo- and Heterobivalent Antibody-Drug ConjugatesMMP-可切割连接器平台用于肿瘤响应性同源和异源双价抗体药物偶联物
errChem. Sci.
IF0
err2025-12-04
err0
errOAAI
errAndrew James Counsell; Stephen J Walsh; Nicola Ashman; Mahri Park; Friederike M. Dannheim; Thomas A King; Thomas Wharton; Jason S Carroll; David R Spring
err分享
err收藏
Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds近期在催化不对称构建固有手性骨架方面的研究进展
errChem. Soc. Rev.
IF0
err2025-10-20
err0
errOAAI
errKai Zhu; David R. Spring; Bing-Feng Shi; Fengzhi Zhang
err分享
err收藏
Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors利用酪蛋白激酶2α（CK2α）的隐匿αD袋递送高效且高选择性的I型抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2025-10-14
err0
errOAAI
errPaul A. Glossop; Paul Brear; Susanne Wright; Neil Flanagan; Melanie S. Glossop; Charlotte A. L. Lane; Richard P. Butt; David R. Spring; Marko Hyvönen; Darren Cawkill
err分享
err收藏
Towards a glutathione-cleavable azobenzene linker for antibody-drug conjugates用于抗体-药物偶联物的谷胱甘肽可裂解的偶氮苯接头
errCHEMICAL COMMUNICATIONS
IF4.2
err2025-10-01
err0
PREAI
errKapun, Mia; Patel, Roshan; Park, Mahri; Perez-Areales, F. Javier; Kostadinova, Kristina A.; Wharton, Thomas; Carroll, Jason S.; Spring, David R.
err分享
err收藏
β-Lactamase cleavable antimicrobial peptide–drug conjugatesβ-内酰胺酶可切割的抗菌肽-药物缀合物
errChem. Sci.
IF7.4
err2025-09-19
err0
errOAAI
errTomas Deingruber; Josephine S. Gaynord; Bee Ha Gan; Kristina A. Kostadinova; Thomas J. O'Brien; Yaw Sing Tan; Jeremy S. Parker; Thomas A. Hunt; Jason S. Carroll; Martin Welch; David R. Spring
err分享
err收藏
Pseudomonas aeruginosa PfpI is a methylglyoxalase
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-04-01
err0
errOAAI
errGrimm, Larson; Wijaya, Andre; Askenasy, Isabel; Nazeer, Rahan Rudland; Seki, Hikaru; Brear, Paul D.; Figueroa, Wendy; Spring, David R.; Welch, Martin
err分享
err收藏
Methods for the Generation of Single-Payload Antibody-Drug Conjugates产生单有效载荷抗体-药物缀合物的方法
errCHEMMEDCHEM
IF3.4
err2025-03-01
err0
PREAI
errWharton, Thomas; Spring, David R.
err分享
err收藏
The 2-methylcitrate cycle and the glyoxylate shunt in Pseudomonas aeruginosa are linked through enzymatic redundancy
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-02-01
err0
errOAAI
errWijaya, Andre J.; Dolan, Stephen K.; Kohlstedt, Michael; Glaeser, Lars; Brear, Paul; Geddis, Stephen; Wittmann, Christoph; Spring, David R.; Welch, Martin
err分享
err收藏
Advances in the Release of Amide-Containing Molecules
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2025-01-28
err0
PREAI
errWharton, Thomas; Spring, David R.
err分享
err收藏
A platform for SpyCatcher conjugation to native antibodiesSpyCatcher 与天然抗体缀合的平台
errCHEMICAL SCIENCE
IF7.4
err2025-01-01
err0
errOAAI
errKrajcovicova, Sona; Wharton, Thomas; Driscoll, Claudia L.; King, Thomas A.; Howarth, Mark R.; Spring, David R.
err分享
err收藏
Novel immunotherapeutics against LGR5 to target multiple cancer types (vol 16, pg 2233, 2024)
errEMBO MOLECULAR MEDICINE
IF8.3
err2024-09-25
err1
errOAAI
errChen, Hung-Chang; Mueller, Nico; Stott, Katherine; Kapeni, Chrysa; Rivers, Eilidh; Sauer, Carolin M.; Beke, Flavio; Walsh, Stephen J.; Ashman, Nicola; O'Brien, Louise; Fard, Amir Rafati; Ghodsinia, Arman; Li, Changtai; Joud, Fadwa; Giger, Olivier; Zlobec, Inti; Olan, Ioana; Aitken, Sarah J.; Hoare, Matthew; Mair, Richard; Serrao, Eva; Brenton, James D.; Garcia-Gimenez, Alicia; Richardson, Simon E.; Huntly, Brian; Spring, David R.; Skjoedt, Mikkel-Ole; Skjodt, Karsten; de la Roche, Marc; de la Roche, Maike
err分享
err收藏

研究方向

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