未登录A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification
Egli, D; Yepiskoposyan, H; Selvaraj, A; Balamurugan, K; Rajaram, R; Simons, A; Multhaup, G; Mettler, S; Vardanyan, A; Georgiev, O; Schaffner, W
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收藏Dimerization of the cellular prion protein inhibits propagation of scrapie prions
Engelke, Anna D.; Gonsberg, Anika; Thapa, Simrika; Jung, Sebastian; Ulbrich, Sarah; Seidel, Ralf; Basu, Shaon; Multhaup, Gerd; Baier, Michael; Engelhard, Martin; Schaetzl, Hermann M.; Winklhofer, Konstanze F.; Tatzelt, Joerg
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收藏Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization
Liebsch, Filip; Aurousseau, Mark R. P.; Bethge, Tobias; McGuire, Hugo; Scolari, Silvia; Herrmann, Andreas; Blunck, Rikard; Bowie, Derek; Multhaup, Gerd
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收藏Model Peptides Uncover the Role of the β-Secretase Transmembrane Sequence in Metal Ion Mediated Oligomerization
Munter, Lisa M.; Sieg, Holger; Bethge, Tobias; Liebsch, Filip; Bierkandt, Frank S.; Schleeger, Michael; Bittner, Heiko J.; Heberle, Joachim; Jakubowski, Norbert; Hildebrand, Peter W.; Multhaup, Gerd
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收藏Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain
Esselens, Cary; Sannerud, Ragna; Gallardo, Rodrigo; Baert, Veerle; Kaden, Daniela; Serneels, Lutgarde; De Strooper, Bart; Rousseau, Frederic; Multhaup, Gerd; Schymkowitz, Joost; Langedijk, Johannes P. M.; Annaert, Wim
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收藏Novel APP/Aß mutation K16N produces highly toxic heteromeric Aß oligomers
Kaden, Daniela; Harmeier, Anja; Weise, Christoph; Munter, Lisa M.; Althoff, Veit; Rost, Benjamin R.; Hildebrand, Peter W.; Schmitz, Dietmar; Schaefer, Michael; Lurz, Rudi; Skodda, Sabine; Yamamoto, Raina; Arlt, Soenke; Finckh, Ulrich; Multhaup, Gerd
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