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收藏Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks
Eysert, Fanny; Kinoshita, Paula-Fernanda; Lagarde, Julien; Lacas-Gervais, Sandra; Xicota, Laura; Dorothee, Guillaume; Bottlaender, Michel; Checler, Frederic; Potier, Marie-Claude; Sarazin, Marie; Chami, Mounia 分享 收藏 The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's diseaseVaillant-Beuchot, Loan; Eysert, Fanny; Duval, Blandine; Kinoshita, Paula Fernanda; Pardossi-Piquard, Raphaelle; Bauer, Charlotte; Eddarkaoui, Sabiha; Buee, Luc; Checler, Frederic; Chami, Mounia 分享 收藏 The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ productionAfram, Elissa; Lauritzen, Inger; Bourgeois, Alexandre; El Manaa, Wejdane; Duplan, Eric; Chami, Mounia; Valverde, Audrey; Charlotte, Bauer; Pardossi-Piquard, Raphaelle; Checler, Frederic 分享 收藏 Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimer's disease patients are associated with cognitive impairmentXicota, Laura; Lagarde, Julien; Eysert, Fanny; Grenier-Boley, Benjamin; Rivals, Isabelle; Botte, Alexandra; Forlani, Sylvie; Landron, Sophie; Gautier, Clement; Gabriel, Cecilia; Bottlaender, Michel; Lambert, Jean-Charles; Chami, Mounia; Sarazin, Marie; Potier, Marie-Claude 分享 收藏 分享 收藏 分享 收藏 Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiologyXBP1s和PINK1之间的功能相互作用的转录和磷酸化依赖性控制线粒体自噬并可能影响帕金森病的病理生理El Manaa, Wejdane; Duplan, Eric; Goiran, Thomas; Lauritzen, Inger; Vaillant Beuchot, Loan; Lacas-Gervais, Sandra; Morais, Vanessa Alexandra; You, Han; Qi, Ling; Salazar, Mario; Ozcan, Umut; Chami, Mounia; Checler, Frederic; Alves da Costa, Cristine 分享 收藏 Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brainValverde, Audrey; Dunys, Julie; Lorivel, Thomas; Debayle, Delphine; Gay, Anne-Sophie; Lacas-Gervais, Sandra; Roques, Bernard P.; Chami, Mounia; Checler, Frederic 分享 收藏 分享 收藏 分享 收藏 Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains淀粉样前体蛋白C末端片段的积累触发了阿尔茨海默氏病模型和人脑中的线粒体结构，功能和线粒体自噬缺陷Vaillant-Beuchot, Loan; Mary, Arnaud; Pardossi-Piquard, Raphaelle; Bourgeois, Alexandre; Lauritzen, Inger; Eysert, Fanny; Kinoshita, Paula Fernanda; Cazareth, Julie; Badot, Celine; Fragaki, Konstantina; Bussiere, Renaud; Martin, Cecile; Mary, Rosanna; Bauer, Charlotte; Pagnotta, Sophie; Paquis-Flucklinger, Veronique; Buee-Scherrer, Valerie; Buee, Luc; Lacas-Gervais, Sandra; Checler, Frederic; Chami, Mounia 分享 收藏 Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer's Disease肌内质网钙atp酶1截短亚型的上调在阿尔茨海默氏病中起致病作用Bussiere, Renaud; Oules, Benedicte; Mary, Arnaud; Vaillant-Beuchot, Loan; Martin, Cecile; El Manaa, Wejdane; Vallee, Deborah; Duplan, Eric; Paterlini-Brechot, Patrizia; Da Costa, Cristine Alves; Checler, Frederic; Chami, Mounia 分享 收藏 β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice ModelsGoiran, Thomas; Duplan, Eric; Chami, Mounia; Bourgeois, Alexandre; El Manaa, Wejdane; Rouland, Lila; Dunys, Julie; Lauritzen, Inger; You, Han; Stambolic, Vuk; Biferi, Maria-Grazia; Barkats, Martine; Pimplikar, Sanjay W.; Sergeant, Nicolas; Colin, Morvane; Morais, Vanessa A.; Pardossi-Piquard, Raphaelle; Checler, Frederic; da Costa, Cristine Alves 分享 收藏 Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficitsLacampagne, Alain; Liu, Xiaoping; Reiken, Steven; Bussiere, Renaud; Meli, Albano C.; Lauritzen, Inger; Teich, Andrew F.; Zalk, Ran; Saint, Nathalie; Arancio, Ottavio; Bauer, Charlotte; Duprat, Fabrice; Briggs, Clark A.; Chakroborty, Shreaya; Stutzmann, Grace E.; Shelanski, Michael L.; Checler, Frederic; Chami, Mounia; Marks, Andrew R. 分享 收藏 Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptorBussiere, Renaud; Lacampagne, Alain; Reiken, Steven; Liu, Xiaoping; Scheuerman, Valerie; Zalk, Ran; Martin, Cecile; Checler, Frederic; Marks, Andrew R.; Chami, Mounia 分享 收藏 Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated MembranesDel Prete, Dolores; Suski, Jan M.; Oules, Benedicte; Debayle, Delphine; Gay, Anne Sophie; Lacas-Gervais, Sandra; Bussiere, Renaud; Bauer, Charlotte; Pinton, Paolo; Paterlini-Brechot, Patrizia; Wieckowski, Mariusz R.; Checler, Frederic; Chami, Mounia 分享 收藏 分享 收藏 Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent mannerBidaux, Gabriel; Borowiec, Anne-Sophie; Gordienko, Dmitri; Beck, Benjamin; Shapovalov, George G.; Lemonnier, Loic; Flourakis, Matthieu; Vandenberghe, Matthieu; Slomianny, Christian; Dewailly, Etienne; Delcourt, Philippe; Desruelles, Emilie; Ritaine, Abigael; Polakowska, Renata; Lesage, Jean; Chami, Mounia; Skryma, Roman; Prevarskaya, Natalia 分享 收藏 分享 收藏 
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