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来

来鲁华 (Luhua Lai)

Peking University

71H指数
529论文数
2.1W被引数
收录论文 205
发表时间
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Discovery of D-peptides that allosterically enhance SARS-CoV-2 3CLpro activity by stabilizing its monomeric state发现通过稳定单聚体状态来别构增强SARS-CoV-2 3CLpro活性的D-肽
errProtein Science
IF5.2
err2026-09-26
err0
PREAI
errLaiyi Feng; Xinliao Ling; Weijie Bian; Changsheng Zhang; Luhua Lai
err分享
err收藏
Guiding large language models to predict edit sequences for molecular synthesizability optimization指导大型语言模型预测分子合成可行性优化的编辑序列
errNature Machine Intelligence
IF23.9
err2026-09-23
err0
PREAI
errJunren Li; Luhua Lai
err分享
err收藏
Protein IDR linkers regulate overall protein conformation and phase separation蛋白质IDR连接子调控整体蛋白质构象和相分离
errCell Reports Physical Science
IF7.3
err2025-11-20
err0
errOAAI
errYujie Yang; Junxi Mu; Yanyan Wang; Luhua Lai
err分享
err收藏
Modeling protein–ligand interactions for drug discovery in the era of deep learning在深度学习时代建模蛋白质-配体相互作用以发现药物
errChem. Soc. Rev.
IF0
err2025-10-21
err0
PREAI
errYuzhe Wang †; Yibo Li †; Jiaxiao Chen; Luhua Lai
err分享
err收藏
DiffPepDock: Efficient protein–peptide docking and binder screening via SE(3)-equivariant diffusionDiffPepDock：通过SE(3)-equivariant扩散实现高效蛋白质-肽段对接和结合物筛选
errProtein Science
IF5.2
err2025-10-14
err0
PREAI
errYuzhe Wang; Fanhao Wang; Laiyi Feng; Changsheng Zhang; Luhua Lai
err分享
err收藏
Benchmarking Cofolding Methods for Molecular Glue Ternary Structure Prediction评估分子胶三聚体结构预测的共折叠方法
errJournal of Chemical Information and Modeling
IF5.3
err2025-10-10
err0
PREAI
errYiyan Liao; Jintao Zhu; Juan Xie; Luhua Lai; Jianfeng Pei
err分享
err收藏
Targeting SARS-CoV-2 Receptor Binding Domain and Main Protease with D-Peptides靶向SARS-CoV-2受体结合域和主要蛋白酶的D-肽
errJournal of Chemical Information and Modeling
IF5.3
err2025-10-01
err0
PREAI
errLaiyi Feng; Jingjia Liu; Chunmei Li; Qian Wang; Luhua Lai; Changsheng Zhang
err分享
err收藏
Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline通过AI辅助管道鉴定肠道微生物胆汁酸代谢酶
errCell
IF42.5
err2025-08-07
err0
PREAI
errYong Ding; Xi Luo; Jiasheng Guo; Baiying Xing; Haoyu Lin; Haohan Ma; Yicun Wang; Meng Li; Chuan Ye; Sen Yan; Kangjie Lin; Jinxin Zhang; Yingying Zhuo; Qixing Nie; Donghui Yang; Zhipeng Zhang; Yanli Pang; Kai Wang; Ming Ma; Luhua Lai; Changtao Jiang
err分享
err收藏
DeepRLI: a multi-objective framework for universal protein–ligand interaction predictionDeepRLI：一种用于通用蛋白质-配体相互作用预测的多目标框架
errDigital Discovery
IF5.6
err2025-07-26
err0
errOAAI
errHaoyu Lin ‡; Jintao Zhu ‡; Shiwei Wang; Yibo Li; Jianfeng Pei; Luhua Lai
err分享
err收藏
Sequence and Structure-based Prediction of Allosteric Sites基于序列和结构的别构位点预测
errJournal of Molecular Biology
IF4.5
err2025-06-24
err0
PREAI
errJuan Xie; Gaoxiang Pan; Luhua Lai
err分享
err收藏
GPx4 is bound to peroxidized membranes by a hydrophobic anchorGPx4通过疏水锚定结构结合到过氧化的膜上。
errJOURNAL OF MOLECULAR BIOLOGY
IF4.5
err2025-06-01
err0
PREAI
errHu, Qingyang; You, Hantian; Li, Kenan; Lai, Luhua; Song, Chen
err分享
err收藏
De Novo Design of Cyclic Peptide Binders Based on Fragment Docking and Assembling基于片段对接和组装的环肽结合物的从头设计
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-04-14
err0
PREAI
errZhang, Changsheng; Wang, Fanhao; Zhang, Tiantian; Yang, Yang; Wang, Liying; Zhang, Xiaoling; Lai, Luhua
err分享
err收藏
Accelerating discovery of bioactive ligands with pharmacophore-informed generative models (vol 16, 2391, 2025)通过药效团信息指导的生成模型加速生物活性配体的发现 (vol 16, 2391, 2025)
errNATURE COMMUNICATIONS
IF15.7
err2025-04-07
err0
errOAAI
errXie, Weixin; Zhang, Jianhang; Xie, Qin; Gong, Chaojun; Ren, Yuhao; Xie, Jin; Sun, Qi; Xu, Youjun; Lai, Luhua; Pei, Jianfeng
err分享
err收藏
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells综合计算分析识别出在癌细胞和T细胞中具有双重作用的疗法靶点
errIMMUNITY
IF26.3
err2025-02-01
err0
PREAI
errLuo, Ce; Zhang, Rui; Guo, Rui; Wu, Lijian; Xue, Teng; He, Yufeng; Jin, Yiteng; Zhao, Yanping; Zhang, Zongxu; Zhang, Peng; Ye, Sitong; Li, Xiaohong; Li, Dian; Zhang, Wubing; Wang, Chenfei; Lai, Luhua; Pan-Hammarstrom, Qiang; Wucherpfennig, Kai W.; Gao, Zhidong
err分享
err收藏
MMFuncPhos: A Multi-Modal Learning Framework for Identifying Functional Phosphorylation Sites and Their Regulatory TypesMMFuncPhos：一个用于识别功能磷酸化位点及其调控类型的多种模态学习框架
errADVANCED SCIENCE
IF14.1
err2025-01-13
err0
errOAAI
errXie, J; Dong, RH; Zhu, JT; Lin, HY; Wang, SW; Lai, LH
err分享
err收藏
Reacon: a template- and cluster-based framework for reaction condition prediction
errCHEMICAL SCIENCE
IF7.4
err2025-01-01
err0
errOAAI
errWang, Zihan; Lin, Kangjie; Pei, Jianfeng; Lai, Luhua
err分享
err收藏
Learning a generalized graph transformer for protein function prediction in dissimilar sequences学习用于异种序列中蛋白质功能预测的广义图变换器
errGIGASCIENCE
IF3.9
err2024-12-05
err0
errOAAI
errFu, Yiwei; Gu, Zhonghui; Luo, Xiao; Guo, Qirui; Lai, Luhua; Deng, Minghua
err分享
err收藏
All-Atom Protein Sequence Design Based on Geometric Deep Learning
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-11-04
err1
PREAI
errLiu, Jiale; Guo, Zheng; You, Hantian; Zhang, Changsheng; Lai, Luhua
err分享
err收藏
Mapping Full Conformational Transition Dynamics of Intrinsically Disordered Proteins Using a Single-Molecule Nanocircuit使用单分子纳米电路绘制内在无序蛋白质的完整构象转变动力学
errACS NANO
IF16
err2024-09-14
err0
PREAI
errYin, Dongbao; Xiong, Ruoyao; Yang, Zhiheng; Feng, Jianfei; Liu, Wenzhe; Li, Shiyun; Li, Mingyao; Ruan, Hao; Li, Jie; Li, Lidong; Lai, Luhua; Guo, Xuefeng
err分享
err收藏
Target-Specific De Novo Peptide Binder Design with DiffPepBuilder使用DiffPepBuilder设计靶标特异性从头肽结合剂
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-09-12
err1
PREAI
errWang, Fanhao; Wang, Yuzhe; Feng, Laiyi; Zhang, Changsheng; Lai, Luhua
err分享
err收藏

研究方向

来鲁华实验室主要利用物理化学结构化学蛋白质及其参与的生命过程结构和功能的关系生物分子作用机理蛋白质结构和功能设计基于结构和基于系统的药物设计方法与应用计算设计方法与程序生物分子机制及系统规律生物分子作用机制蛋白质研究药物和生物系统设计，试图提示生物系统运行的分子机制
合作学者
合作期刊
Chuan He 封面图
Chuan He (Chuan He)
H 指数: 161 · 论文数: 979
陈豪 封面图
陈豪 (Hao Chen)
H 指数: 139 · 论文数: 5.6K
J
Joseph S. Takahashi
H 指数: 128 · 论文数: 451
张
张军 (Jun Zhang)
H 指数: 124 · 论文数: 4.5K
刘
刘颖 (Ying Liu)
H 指数: 118 · 论文数: 2.5K
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