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收藏Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Siegel, Dustin S.; Hui, Hon C.; Pitts, Jared; Vermillion, Meghan S.; Ishida, Kazuya; Rautiola, Davin; Keeney, Michael; Irshad, Hammad; Zhang, Lijun; Chun, Kwon; Chin, Gregory; Goyal, Bindu; Doerffler, Edward; Yang, Hai; Clarke, Michael O.; Palmiotti, Chris; Vijjapurapu, Arya; Riola, Nicholas C.; Stray, Kirsten; Murakami, Eisuke; Ma, Bin; Wang, Ting; Zhao, Xiaofeng; Xu, Yili; Lee, Gary; Marchand, Bruno; Seung, Minji; Nayak, Arabinda; Tomkinson, Adrian; Kadrichu, Nani; Ellis, Scott; Barauskas, Ona; Feng, Joy Y.; Perry, Jason K.; Perron, Michel; Bilello, John P.; Kuehl, Philip J.; Subramanian, Raju; Cihlar, Tomas; Mackman, Richard L. 分享 收藏 Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuationLiu, Po-Ting; Keele, Brandon F.; Abbink, Peter; Mercado, Noe B.; Liu, Jinyan; Bondzie, Esther A.; Chandrashekar, Abishek; Borducchi, Erica N.; Hesselgesser, Joseph; Mish, Michael; Chin, Gregory; Bekerman, Elena; Geleziunas, Romas; Barouch, Dan H. 分享 收藏 Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis BMackman, Richard L.; Mish, Michael; Chin, Gregory; Perry, Jason K.; Appleby, Todd; Aktoudianakis, Vangelis; Metobo, Sammy; Pyun, Peter; Niu, Congrong; Daffis, Stephane; Yu, Helen; Zheng, Jim; Villasenor, Armando G.; Zablocki, Jeff; Chamberlain, Jason; Jin, Haolun; Lee, Gary; Suekawa-Pirrone, Kimberley; Santos, Rex; Delaney, William E.; Fletcher, Simon P. 分享 收藏 Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunctionSenatorov, Vladimir V., Jr.; Friedman, Aaron R.; Milikovsky, Dan Z.; Ofer, Jonathan; Saar-Ashkenazy, Rotem; Charbash, Adiel; Jahan, Naznin; Chin, Gregory; Mihaly, Eszter; Lin, Jessica M.; Ramsay, Harrison J.; Moghbel, Ariana; Preininger, Marcela K.; Eddings, Chelsy R.; Harrison, Helen V.; Patel, Rishi; Shen, Yizhuo; Ghanim, Hana; Sheng, Huanjie; Veksler, Ronel; Sudmant, Peter H.; Becker, Albert; Hart, Barry; Rogawski, Michael A.; Dillin, Andrew; Friedman, Alon; Kaufer, Daniela 分享 收藏 Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor结构引导的新型，有效和口服生物可利用的3，5-二甲基异恶唑芳基-苯并咪唑BET溴结构域抑制剂的发现Sperandio, David; Aktoudianakis, Vangelis; Babaoglu, Kerim; Chen, Xiaowu; Elbel, Kristyna; Chin, Gregory; Corkey, Britton; Du, Jinfa; Jiang, Bob; Kobayashi, Tetsuya; Mackman, Richard; Martinez, Ruben; Yang, Hai; Zablocki, Jeff; Kusam, Saritha; Jordan, Kim; Webb, Heather; Bates, Jamie G.; Lad, Latesh; Mish, Michael; Niedziela-Majka, Anita; Metobo, Sammy; Sapre, Annapurna; Hung, Magdeleine; Jin, Debi; Fung, Wanchi; Kan, Elaine; Eisenberg, Gene; Larson, Nate; Newby, Zachary E. R.; Lansdon, Eric; Tay, Chin; Neve, Richard M.; Shevick, Sophia L.; Breckenridge, David G. 分享 收藏 分享 收藏 分享 收藏 Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin MacrocycleMackman, Richard L.; Steadman, Victoria A.; Dean, David K.; Jansa, Petr; Poullennec, Karine G.; Appleby, Todd; Austin, Carol; Blakemore, Caroline A.; Cai, Ruby; Cannizzaro, Carina; Chin, Gregory; Chiva, Jean-Yves C.; Dunbar, Neil A.; Fliri, Hans; Highton, Adrian J.; Hui, Hon; Ji, Mingzhe; Jin, Haolun; Karki, Kapil; Keats, Andrew J.; Lazarides, Linos; Lee, Yu-Jen; Liclican, Albert; Mish, Michael; Murray, Bernard; Pettit, Simon B.; Pyun, Peter; Sangi, Michael; Santos, Rex; Sanvoisin, Jonathan; Schmitz, Uli; Schrier, Adam; Siegel, Dustin; Sperandio, David; Stepan, George; Tian, Yang; Watt, Gregory M.; Yang, Hai; Schultz, Brian E. 分享 收藏 分享 收藏 In vitro and in vivo characterization of the selective toll-like receptor 8 agonist GS-9688Daffis, S.; Ramakrishnan, D.; Niu, C.; Zheng, J.; Santos, R.; Mish, M.; Chin, G.; Aktoudianakis, V.; Metobo, S.; Pyun, H-J; Yu, H.; Lee, G.; Palazzo, A.; Frey, C.; Pflanz, S.; Delaney, W. E.; Fletcher, S. P.; Mackman, R. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 
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