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Pre-clinical efficacy of trastuzumab deruxtecan plus sotorasib in KRASG12C-mutant non-small cell lung cancer and exploratory HER2 profiling in human tumors 曲妥珠单抗德鲁克替康联合索托拉西布在KRASG12C突变非小细胞肺癌中的临床前疗效及人类肿瘤中HER2的探索性分析 Ozakinci, Hilal; Desai, Bina; Kalos, Denise; Chen, Dung-Tsa; Henry, Menkara; Solanki, Hitendra; Boyle, Theresa A.; Bittar, Humberto E. Trejo; Nazario, Gina S.; Haura, Eric B.; Marusyk, Andriy; Pellini, Bruna 分享 收藏
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK-driven lung cancer by concurrent integrin and MET signaling Hu, Qianqian; Remsing Rix, Lily L.; Desai, Bina; Miroshnychenko, Daria; Li, Xueli; Welsh, Eric A.; Fang, Bin; Wright, Gabriela M.; Chaudhary, Neelkamal; Kroeger, Jodi L.; Doebele, Robert C.; Koomen, John M.; Haura, Eric B.; Marusyk, Andriy; Rix, Uwe 分享 收藏
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RTK signaling and WT RAS activity as vulnerabilities in tumors with acquired resistance to GDP-state selective KRASG12C inhibitors in preclinical models Solanki, Hitendra S.; Shah, Harshit; Imbody, Denis; Desai, Bina; Stewart, Paul A.; Fang, Bin; Stern, Yaakov; Darville, Lancia N.; Koomen, John M.; Marusyk, Andriy; Ahler, Ethan; Aronchik, Ida; Singh, Mallika; Haura, Eric B. 分享 收藏
Positive ecological interaction between therapy-resistant and sensitive cells, mediated by stromal niche, slows the expansion of resistant subpopulations and promotes tumor heterogeneity Desai, Bina; Robertson-Tessi, Mark; Vander Velde, Robert; Miti, Tatiana; Yarlagadda, Sagnik; Shah, Rishi; Miroshnychenko, Daria; Basanta, David; Anderson, Alexander; Marusyk, Andriy 分享 收藏
Sotorasib/SHP2 inhibitors combo, KRASG12C(ON)I and RASMULTI(ON)I effectively target KRASG12C tumors developing secondary resistance to Sotorasib via KRASG12C amplification Solanki, Hitendra S.; Imbody, Denis; Desai, Bina; Kato, Ryoji; Stewart, Paul A.; Stern, Yaakov; Majumder, Anurima; Bridenstine, Liznair; Sarca, Bhaswati; Miroshnychenko, Dada; Aronchik, Ida; Marusyk, Andriy; Haura, Eric B. 分享 收藏
Wildtype RAS activity and PI3K signaling as new vulnerabilities in cells with acquired resistance to sotorasib Imbody, Denis; Solanki, Hitendra S.; Desai, Bina; Stewart, Paul A.; Stern, Yaakov; Kato, Ryoji; Majumder, Anurima; Bridenstine, Liznair; Xieraili, Aobuli; Fang, Bin; Darville, Lancia; Kinose, Fumi; Koomen, John M.; Rix, Uwe; Marusyk, Andriy; Haura, Eric B. 分享 收藏
Radiotherapy and NK cell-based immunotherapy: An evolutionary double-bind Luddy, Kimberly; West, Jeffery; Robertson-Tessi, Mark; Desai, Bina; Bursell, Taylor M.; Barrett, Sarah; Brown, Joel; O'Sullivan, Jacintha; Gatenby, Robert; Marignol, Laure; Anderson, Alexander R.; O'Farrelly, Cliona 分享 收藏
Stromal facilitated multifactorial resistance to tumor cells against targeted therapies in ALK plus NSCLC Desai, Bina; Miti, Tatiana; Miroshnychenko, Daria; Marusyk, Viktoriya; Gatenbee, Chandler; Henry, Menkara; Rix, Uwe; Anderson, Alexander; Haura, Eric; Basanta, David; Marusyk, Andriy 分享 收藏
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IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells 肿瘤相关成纤维细胞分泌的IGF结合蛋白诱导肺癌细胞的上下文依赖性药物增敏 Rix, Lily L. Remsing; Sumi, Natalia J.; Hu, Qianqian; Desai, Bina; Bryant, Annamarie T.; Li, Xueli; Welsh, Eric A.; Fang, Bin; Kinose, Fumi; Kuenzi, Brent M.; Chen, Y. Ann; Antonia, Scott J.; Lovly, Christine M.; Koomen, John M.; Haura, Eric B.; Marusyk, Andriy; Rix, Uwe 分享 收藏
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Anti-tumor effects of an ID antagonist with no observed acquired resistance Wojnarowicz, Paulina M.; Escolano, Marta Garcia; Huang, Yun-Han; Desai, Bina; Chin, Yvette; Shah, Riddhi; Xu, Sijia; Yadav, Saurabh; Yaklichkin, Sergey; Ouerfelli, Ouathek; Soni, Rajesh Kumar; Philip, John; Montrose, David C.; Healey, John H.; Rajasekhar, Vinagolu K.; Garland, William A.; Ratiu, Jeremy; Zhuang, Yuan; Norton, Larry; Rosen, Neal; Hendrickson, Ronald C.; Zhou, Xi Kathy; Iavarone, Antonio; Massague, Joan; Dannenberg, Andrew J.; Lasorella, Anna; Benezra, Robert 分享 收藏
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Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures Vander Velde, Robert; Yoon, Nara; Marusyk, Viktoriya; Durmaz, Arda; Dhawan, Andrew; Miroshnychenko, Daria; Lozano-Peral, Diego; Desai, Bina; Balynska, Olena; Poleszhuk, Jan; Liu Kenian; Teng, Mingxiang; Abazeed, Mohamed; Mian, Omar; Tan, Aik Choon; Haura, Eric; Scott, Jacob; Marusyk, Andriy 分享 收藏
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization Wojnarowicz, Paulina M.; Lima e Silva, Raquel; Ohnaka, Masayuki; Lee, Sang Bae; Chin, Yvette; Kulukian, Anita; Chang, Sung-Hee; Desai, Bina; Escolano, Marta Garcia; Shah, Riddhi; Garcia-Cao, Marta; Xu, Sijia; Kadam, Rashmi; Goldgur, Yehuda; Miller, Meredith A.; Ouerfelli, Ouathek; Yang, Guangli; Arakawa, Tsutomu; Albanese, Steven K.; Garland, William A.; Stoller, Glenn; Chaudhary, Jaideep; Norton, Larry; Soni, Rajesh Kumar; Philip, John; Hendrickson, Ronald C.; Iavarone, Antonio; Dannenberg, Andrew J.; Chodera, John D.; Pavletich, Nikola; Lasorella, Anna; Campochiaro, Peter A.; Benezra, Robert 分享 收藏
A small molecule pan Id protein antagonist shows strong antitumor activity Wojnarowicz, Paulina M.; Desai, Bina; Chin, Yvette; Lee, Sang Bae; Garcia-Cao, Marta; Ouerfelli, Ouathek; Yang, Guangli; Xu, Sijia; Goldgur, Yehuda; Miller, Meredith A.; Chaudhary, Jaideep; Garland, William A.; Albanese, Steven K.; Soni, Rajesh; Philip, John; Norton, Larry; Rosen, Neal; Hendrickson, Ronald C.; Zhou, Xi Kathy; Iavarone, Antonio; Dannenberg, Andrew J.; Chodera, John D.; Pavletich, Nikola; Lasorella, Anna; Benezra, Robert 分享 收藏
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