未登录 Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors Tarr, James C.; Salovich, James M.; Aichinger, Martin; Jeon, Kyuok; Veerasamy, Nagarathanam; Sensintaffar, John L.; Arnhof, Heribert; Samwer, Matthias; Christov, Plamen P.; Kim, Kwangho; Wunberg, Tobias; Schweifer, Norbert; Trapani, Francesca; Arnold, Allison; Martin, Florian; Zhao, Bin; Miriyala, Nagaraju; Sgubin, Danielle; Fogarty, Stuart; Moore, William J.; Stott, Gordon M.; Olejniczak, Edward T.; Engelhardt, Harald; Rudolph, Dorothea; Lee, Taekyu; Mcconnell, Darryl B.; Fesik, Stephen W. 分享 收藏
BI-732, a novel fourth-generation EGFR-TKI, demonstrates promising activities against the C797S-mediated EGFRTKI resistance Lee, Eun Ji; Lee, Jiyun; Oh, Seung Yeon; Lee, You Won; Kim, Ju Young; Choi, Su-Jin; Park, Sewon; Yu, Mi Ra; Kim, Jae Hwan; Pyo, Kyoung-Ho; Lee, Jii Bum; Hong, Min Hee; Lim, Sun Min; Baum, Anke; Woelflingseder, Lydia; Engelhardt, Harald; Petronczki, Mark; Solca, Flavio; Yun, Mi Ran; Cho, Byoung Chul 分享 收藏
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling 发现对HER2外显子20插入驱动的肿瘤有效的和选择性的HER2抑制剂，其保留野生型EGFR信号传导 Wilding, Birgit; Scharn, Dirk; Boese, Dietrich; Baum, Anke; Santoro, Valeria; Chetta, Paolo; Schnitzer, Renate; Botesteanu, Dana A.; Reiser, Christoph; Kornigg, Stefan; Knesl, Petr; Hoermann, Alexandra; Koeferle, Anna; Corcokovic, Maja; Lieb, Simone; Scholz, Guido; Bruchhaus, Jens; Spina, Markus; Balla, Josef; Peric-Simov, Biljana; Zimmer, Jasmin; Mitzner, Sophie; Fett, Thomas N.; Beran, Alexandra; Lamarre, Lyne; Gerstberger, Thomas; Gerlach, Daniel; Bauer, Markus; Bergner, Andreas; Schlattl, Andreas; Bader, Gerd; Treu, Matthias; Engelhardt, Harald; Zahn, Stephan; Fuchs, Julian E.; Zuber, Johannes; Ettmayer, Peter; Pearson, Mark; Petronczki, Mark; Kraut, Norbert; McConnell, Darryl B.; Solca, Flavio; Neumuller, Ralph A. 分享 收藏
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Variants in Mitochondrial ATP Synthase Cause Variable Neurologic Phenotypes Zech, Michael; Kopajtich, Robert; Steinbruecker, Katja; Bris, Celine; Gueguen, Naig; Feichtinger, Rene G.; Achleitner, Melanie T.; Duzkale, Neslihan; Perivier, Maximilien; Koch, Johannes; Engelhardt, Harald; Freisinger, Peter; Wagner, Matias; Brunet, Theresa; Berutti, Riccardo; Smirnov, Dmitrii; Navaratnarajah, Tharsini; Rodenburg, Richard J. T.; Pais, Lynn S.; Austin-Tse, Christina; O'Leary, Melanie; Boesch, Sylvia; Jech, Robert; Bakhtiari, Somayeh; Jin, Sheng Chih; Wilbert, Friederike; Kruer, Michael C.; Wortmann, Saskia B.; Eckenweiler, Matthias; Mayr, Johannes A.; Distelmaier, Felix; Steinfeld, Robert; Winkelmann, Juliane; Prokisch, Holger 分享 收藏
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PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR Spectroscopy Platzer, Gerald; Mayer, Moriz; Beier, Andreas; Brueschweiler, Sven; Fuchs, Julian E.; Engelhardt, Harald; Geist, Leonhard; Bader, Gerd; Schoerghuber, Julia; Lichtenecker, Roman; Wolkerstorfer, Bernhard; Kessler, Dirk; McConnell, Darryl B.; Konrat, Robert 分享 收藏
Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance 选择性和有效的CDK8/19抑制剂增强NK细胞活性并促进肿瘤监测 Hofmann, Marco H.; Mani, Rajeswaran; Engelhardt, Harald; Impagnatiello, Maria A.; Carotta, Sebastian; Kerenyi, Marc; Lorenzo-Herrero, Seila; Boettcher, Jark; Scharn, Dirk; Arnhof, Heribert; Zoephel, Andreas; Schnitzer, Renate; Gerstberger, Thomas; Sanderson, Michael P.; Rajgolikar, Girish; Goswami, Swagata; Vasu, Sumithira; Ettmayer, Peter; Gonzalez, Segundo; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert; Muthusamy, Natarajan; Moll, Juergen 分享 收藏
Planctopirus ephydatiae, a novel Planctomycete isolated from a freshwater sponge Kohn, T.; Wiegand, S.; Boedeker, C.; Rast, P.; Heuer, A.; Jetten, M. S. M.; Schueler, M.; Becker, S.; Rohde, C.; Mueller, R-W; Bruemmer, F.; Rohde, M.; Engelhardt, H.; Jogler, M.; Jogler, C. 分享 收藏
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors Engelhardt, Harald; Boese, Dietrich; Petronczki, Mark; Scharn, Dirk; Bader, Gerd; Baum, Anke; Bergner, Andreas; Chong, Eugene; Doebel, Sandra; Egger, Georg; Engelhardt, Christian; Ettmayer, Peter; Fuchs, Julian E.; Gerstberger, Thomas; Gonnella, Nina; Grimm, Andreas; Grondal, Elisabeth; Haddad, Nizar; Hopfgartner, Barbara; Kousek, Roland; Krawiec, Mariusz; Kriz, Monika; Lamarre, Lyne; Leung, Joyce; Mayer, Moriz; Patel, Nitinchandra D.; Simov, Biljana Peric; Reeves, Jonathan T.; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Solca, Flavio; Stadtmueller, Heinz; Tan, Zhulin; Wunberg, Tobias; Zoephel, Andreas; McConnell, Darryl B. 分享 收藏
Selective and potent CDK8 inhibitors enhance NK cell activity and promote tumor surveillance Hofmann, Marco H.; Mani, Rajeswaran; Engelhardt, Harald; Impagnatiello, Maria A.; Carotta, Sebastian; Kerenyi, Marc A.; Lorenzo-Herrero, Seila; Boettcher, Jark; Scharn, Dirk; Arnhof, Heribert; Zoephel, Andreas; Schnitzer, Renate; Gerstberger, Thomas; Rajgolikar, Girish; Goswami, Swagata; Vasu, Sumithira; Ettmayer, Peter; Gonzalez, Segundo R.; Pearson, Mark; McConnell, Darryl B.; Kraut, Norbert; Muthusamy, Natarajan; Moll, Juergen 分享 收藏
Synergistic activity of BET inhibitor BI 894999 with PLK inhibitor volasertib in AML in vitro and in vivo Tontsch-Grunt, Ulrike; Rudolph, Dorothea; Waizenegger, Irene; Baum, Anke; Gerlach, Daniel; Engelhardt, Harald; Wurm, Melanie; Savarese, Fabio; Schweifer, Norbert; Kraut, Norbert 分享 收藏
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML Gerlach, Daniel; Tontsch-Grunt, Ulrike; Baum, Anke; Popow, Johannes; Scharn, Dirk; Hofmann, Marco H.; Engelhardt, Harald; Kaya, Onur; Beck, Janina; Schweifer, Norbert; Gerstberger, Thomas; Zuber, Johannes; Savarese, Fabio; Kraut, Norbert 分享 收藏
Structural studies of Acidianus tailed spindle virus reveal a structural paradigm used in the assembly of spindle- shaped viruses Hochstein, Rebecca; Bollschweiler, Daniel; Dharmavaram, Sanjay; Lintner, Nathanael G.; Plitzko, Jurgen M.; Bruinsma, Robijn; Engelhardt, Harald; Young, Mark J.; Klug, William S.; Lawrence, C. Martin 分享 收藏
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Development of selective and potent CDK8 inhibitors that increase NK cell activity, which translates in tumor surveillance Hofmann, Marco H.; Engelhardt, Harald; Carotta, Sebastian; Arnhof, Heribert; Scharn, Dirk; Kerenyi, Marc; Mayer, Moritz; Gmaschitz, Gerhard; Egger, Georg; Engelhardt, Christian; Sanderson, Michael; Impagnatiello, Maria A.; Schnitzer, Renate; Pearson, Mark; McConnell, Darryl; Kraut, Norbert; Moll, Jurgen 分享 收藏
Determining the bacterial cell biology of Planctomycetes Boedeker, Christian; Schueler, Margarete; Reintjes, Greta; Jeske, Olga; van Teeseling, Muriel C. F.; Jogler, Mareike; Rast, Patrick; Borchert, Daniela; Devos, Damien P.; Kucklick, Martin; Schaffer, Miroslava; Kolter, Roberto; van Niftrik, Laura; Engelmann, Susanne; Amann, Rudolf; Rohde, Manfred; Engelhardt, Harald; Jogler, Christian 分享 收藏
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Planctomycetes do possess a peptidoglycan cell wall Jeske, Olga; Schueler, Margarete; Schumann, Peter; Schneider, Alexander; Boedeker, Christian; Jogler, Mareike; Bollschweiler, Daniel; Rohde, Manfred; Mayer, Christoph; Engelhardt, Harald; Spring, Stefan; Jogler, Christian 分享 收藏
Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 983.36 of the human histamine H4 receptor Nijmeijer, S.; Engelhardt, H.; Schultes, S.; van de Stolpe, A. C.; Lusink, V.; de Graaf, C.; Wijtmans, M.; Haaksma, E. E. J.; de Esch, I. J. P.; Stachurski, K.; Vischer, H. F.; Leurs, R. 分享 收藏
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