未登录 The antiviral BDGR-49 provides protection from lethal, neurotropic Venezuelan equine encephalitis virus intranasal infection in mice 抗病毒BDGR-49可保护小鼠免受致死性，嗜神经性委内瑞拉马脑炎病毒鼻内感染 Williams, Evan P.; Xue, Yi; Vogel, Peter; Yang, Dong; Ponce-Flores, Alejandro; Li, Xiaoyu; Ogorek, Tyler J.; Saini, Manisha; Iulek, Jorge; Ruiz, Francesc Xavier; Arnold, Eddy; Golden, Jennifer E.; Meibohm, Bernd; Jonsson, Colleen B. 分享 收藏
Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors Tan, Bin; Liang, Xueying; Ansari, Ahmadullah; Jadhav, Prakash; Tan, Haozhou; Li, Kan; Ruiz, Francesc Xavier; Arnold, Eddy; Deng, Xufang; Wang, Jun 分享 收藏
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Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors 发现带有哌嗪磺酰基的二芳基嘧啶衍生物作为有效的HIV-1非核苷类逆转录酶抑制剂 Jiang, Xiangyi; Huang, Boshi; Rumrill, Shawn; Pople, David; Zalloum, Waleed A.; Kang, Dongwei; Zhao, Fabao; Ji, Xiangkai; Gao, Zhen; Hu, Lide; Wang, Zhao; Xie, Minghui; De Clercq, Erik; Ruiz, Francesc X.; Arnold, Eddy; Pannecouque, Christophe; Liu, Xinyong; Zhan, Peng 分享 收藏
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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach Mansouri, Mahta; Rumrill, Shawn; Dawson, Shane; Johnson, Adam; Pinson, Jo-Anne; Gunzburg, Menachem J.; Latham, Catherine F.; Barlow, Nicholas; Mbogo, George W.; Ellenberg, Paula; Headey, Stephen J.; Sluis-Cremer, Nicolas; Tyssen, David; Bauman, Joseph D.; Ruiz, Francesc X.; Arnold, Eddy; Chalmers, David K.; Tachedjian, Gilda 分享 收藏
Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro Yadav, Ruchi; Courouble, Valentine V.; Dey, Sanjay K.; Harrison, Jerry Joe E. K.; Timm, Jennifer; Hopkins, Jesse B.; Slack, Ryan L.; Sarafianos, Stefan G.; Ruiz, Francesc X.; Griffin, Patrick R.; Arnold, Eddy 分享 收藏
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine Singh, Abhimanyu K.; De Wijngaert, Brent; Bijnens, Marc; Uyttersprot, Kris; Nguyen, Hoai; Martinez, Sergio E.; Schols, Dominique; Herdewijn, Piet; Pannecouque, Christophe; Arnold, Eddy; Das, Kalyan 分享 收藏
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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition Baldwin, Eric T.; Gotte, Matthias; Tchesnokov, Egor P.; Arnold, Eddy; Hagel, Margit; Nichols, Charles; Dossang, Pam; Lamers, Marieke; Wan, Paul; Steinbacher, Stefan; Romero, Donna L. 分享 收藏
HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites (vol 64, pg 16530, 2021) Losada, Natalie; Ruiz, Francesc X.; Curreli, Francesca; Gruber, Kevin; Pilch, Alyssa; Altieri, Andrea; Kurkin, Alexander V.; Das, Kalyan; Debnath, Asim K.; Arnold, Eddy 分享 收藏
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Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first 6 months of the COVID-19 pandemic Lubin, Joseph H.; Zardecki, Christine; Dolan, Elliott M.; Lu, Changpeng; Shen, Zhuofan; Dutta, Shuchismita; Westbrook, John D.; Hudson, Brian P.; Goodsell, David S.; Williams, Jonathan K.; Voigt, Maria; Sarma, Vidur; Xie, Lingjun; Venkatachalam, Thejasvi; Arnold, Steven; Alvarado, Luz Helena Alfaro; Catalfano, Kevin; Khan, Aaliyah; McCarthy, Erika; Staggers, Sophia; Tinsley, Brea; Trudeau, Alan; Singh, Jitendra; Whitmore, Lindsey; Zheng, Helen; Benedek, Matthew; Currier, Jenna; Dresel, Mark; Duvvuru, Ashish; Dyszel, Britney; Fingar, Emily; Hennen, Elizabeth M.; Kirsch, Michael; Khan, Ali A.; Labrie-Cleary, Charlotte; Laporte, Stephanie; Lenkeit, Evan; Martin, Kailey; Orellana, Marilyn; de la Campa, Melanie Ortiz-Alvarez; Paredes, Isaac; Wheeler, Baleigh; Rupert, Allison; Sam, Andrew; See, Katherine; Zapata, Santiago Soto; Craig, Paul A.; Hall, Bonnie L.; Jiang, Jennifer; Koeppe, Julia R.; Mills, Stephen A.; Pikaart, Michael J.; Roberts, Rebecca; Bromberg, Yana; Hoyer, J. Steen; Duffy, Siobain; Tischfield, Jay; Ruiz, Francesc X.; Arnold, Eddy; Baum, Jean; Sandberg, Jesse; Brannigan, Grace; Khare, Sagar D.; Burley, Stephen K. 分享 收藏
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2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies Kang, Dongwei; Ruiz, Francesc X.; Sun, Yanying; Feng, Da; Jing, Lanlan; Wang, Zhao; Zhang, Tao; Gao, Shenghua; Sun, Lin; De Clercq, Erik; Pannecouque, Christophe; Arnold, Eddy; Zhan, Peng; Liu, Xinyong 分享 收藏
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Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase Nguyen, Phuong D. M.; Zheng, Jie; Gremminger, Thomas J.; Qiu, Liming; Zhang, Dong; Tuske, Steve; Lange, Margaret J.; Griffin, Patrick R.; Arnold, Eddy; Chen, Shi-Jie; Zou, Xiaoqin; Heng, Xiao; Burke, Donald H. 分享 收藏
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