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L

Lude Franke

university medical center groningen
H指数:140
被引数:10.3万

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Human genetics implicates a BACH2–NRF2 axis in fetal haemoglobin activation

人类遗传学提示BACH2–NRF2轴在胎儿血红蛋白激活中的作用

Nature
IF48.5
2026-09-300
OAAI
Chun-Jie Guo; Uma P. Arora; Xiaoheng Cheng; Wanying Xu; Liam D. Cato; Rick Li; Henry Y. Lu; Andrew J. Lee; Fulong Yu; Gaurav Agarwal; Peng Lyu; Tianyi Ye; Mateusz Antoszewski; Mariel Wissmann; Baraka S. Mkumbe; Supachai Ekwattanakit; Patrick Deelen; Liberata Mwita; Raphael Sangeda; Thidarat Suksangpleng; Suchada Riolueang; Paola G. Bronson; Dirk S. Paul; Emily Kawabata; William J. Astle; Francois Aguet; Kristin Ardlie; Aitzkoa Lopez de Lapuente Portilla; Guolian Kang; Yingze Zhang; Seyed Mehdi Nouraie; Victor R. Gordeuk; Mark T. Gladwin; Melanie E. Garrett; Allison Ashley-Koch; Marilyn J. Telen; Brian Custer; Shannon Kelly; Carla Luana Dinardo; Ester C. Sabino; Paula Loureiro; Anna Bárbara Carneiro-Proietti; Cláudia Maximo; Adriana Méndez; Angelika Hammerer-Lercher; Julie Makani; Vivien A. Sheehan; Mitchell J. Weiss; Lude Franke; Björn Nilsson; Adam S. Butterworth; Vip Viprakasit; Siana Nkya; Vijay G. Sankaran
Regulatory grammar in human promoters uncovered by MPRA-based deep learning

基于MPRA的深度学习发现的人类促进者中的调节语法

Nature
IF48.5
2026-02-040
OA
Lucía Barbadilla-Martínez; Noud Klaassen; Vinícius H. Franceschini-Santos; Jérémie Breda; Hatice Yücel; Miguel Hernández-Quiles; Tijs van Lieshout; Carlos G. Urzua Traslaviña; Minh Chau Luong Boi; Maryam Akbarzadeh; Celia Hermana-Garcia-Agullo; Sebastian Gregoricchio; Marcel de Haas; Roy Straver; Sarah Derks; Wilbert Zwart; Emile Voest; Lude Franke; Michiel Vermeulen; Jeroen de Ridder; Bas van Steensel
DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease

涉及脂质代谢的基因的DNA甲基化驱动脂联素水平及代谢性疾病

Diabetologia
IF10.2
2025-10-080
OA
Lucy Sinke; Thomas Delerue; Rory Wilson; Xueling Lu; Yujing Xia; Ricardo Costeira; M. Kamal Nasr; Marian Beekman; Lude Franke; Alexandra Zhernakova; Jingyuan Fu; Christian Gieger; Christian Herder; Wolfgang Koenig; Annette Peters; José M. Ordovas; Marcus Dörr; Hans J. Grabe; Matthias Nauck; Jordana T. Bell; Alexander Teumer; Harold Snieder; Melanie Waldenberger; P. Eline Slagboom; Bastiaan T. Heijmans
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

跨基因座表达数量性状基因座（trans-eQTL）作图将USP18列为干扰素反应的负调控因子，位于狼疮风险基因座上

Nature Communications
IF15.7
2025-10-020
OAAI
Krista Freimann; Anneke Brümmer; Robert Warmerdam; Tarran S. Rupall; Ana Laura Hernández-Ledesma; Joshua Chiou; Emily R. Holzinger; Joseph C. Maranville; Nikolina Nakic; Halit Ongen; Luca Stefanucci; Michael C. Turchin; Lude Franke; Urmo Võsa; Carla P. Jones; Alejandra Medina-Rivera; Gosia Trynka; Kai Kisand; Sven Bergmann; Kaur Alasoo
Low-cost generation of clinical-grade , layperson-friendly pharmacogenetic passports using oligonucleotide arrays

使用寡核苷酸阵列低成本生成临床级、面向非专业人士的药物基因组学护照

AMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
2025-05-010
OAAI
Lanting, P; Warmerdam, R; Slager, J; Brugge, H; Ochi, T; Benjamins, M; Lopera-Maya, E; Jankipersadsing, S; Gelderloos-Arends, J; Teuben, D; Hendriksen, D; Charbon, B; Johansson, L; Munnink, TO; de Boer-Veger, N; Wilffert, B; Swertz, M; Touw, D; Deelen, P; Knoers, N; Dekens, J; Franke, L
Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation

对血浆代谢组的表观基因组全关联研究表明，甘氨酸和丝氨酸途径通过DNA甲基化进行自我调节

CLINICAL EPIGENETICS
IF4.4
2024-08-130
OAAI
Wu, Jiafei; Palasantzas, Victoria; Andreu-Sanchez, Sergio; Ploesch, Torsten; Leonard, Sam; Li, Shuang; Bonder, Marc Jan; Westra, Harm-Jan; van Meurs, Joyce; Ghanbari, Mohsen; Franke, Lude; Zhernakova, Alexandra; Fu, Jingyuan; Hoogerland, Joanne A.; Zhernakova, Daria V.
Understanding the genetic complexity of puberty timing across the allele frequency spectrum

了解等位基因频谱中青春期时间的遗传复杂性

NATURE GENETICS
IF31.8
2024-07-013
OAAI
Kentistou, Katherine A.; Kaisinger, Lena R.; Stankovic, Stasa; Vaudel, Marc; de Oliveira, Edson Mendes; Messina, Andrea; Walters, Robin G.; Liu, Xiaoxi; Busch, Alexander S.; Helgason, Hannes; Thompson, Deborah J.; Santoni, Federico; Petricek, Konstantin M.; Zouaghi, Yassine; Huang-Doran, Isabel; Gudbjartsson, Daniel F.; Bratland, Eirik; Lin, Kuang; Gardner, Eugene J.; Zhao, Yajie; Jia, Raina Y.; Terao, Chikashi; Riggan, Marjorie J.; Bolla, Manjeet K.; Yazdanpanah, Mojgan; Yazdanpanah, Nahid; Bradfield, Jonathan P.; Broer, Linda; Campbell, Archie; Chasman, Daniel I.; Cousminer, Diana L.; Franceschini, Nora; Franke, Lude H.; Girotto, Giorgia; He, Chunyan; Jarvelin, Marjo-Riitta; Joshi, Peter K.; Kamatani, Yoichiro; Karlsson, Robert; Luan, Jian'an; Lunetta, Kathryn L.; Magi, Reedik; Mangino, Massimo; Medland, Sarah E.; Meisinger, Christa; Noordam, Raymond; Nutile, Teresa; Concas, Maria Pina; Polasek, Ozren; Porcu, Eleonora; Ring, Susan M.; Sala, Cinzia; Smith, Albert V.; Tanaka, Toshiko; Van der Most, Peter J.; Vitart, Veronique; Wang, Carol A.; Willemsen, Gonneke; Zygmunt, Marek; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antoniou, Antonis C.; Auer, Paul L.; Barnes, Catriona L. K.; Beckmann, Matthias W.; de Gonzalez, Amy Berrington; Bogdanova, Natalia V.; Bojesen, Stig E.; Brenner, Hermann; Buring, Julie E.; Canzian, Federico; Chang-Claude, Jenny; Couch, Fergus J.; Cox, Angela; Crisponi, Laura; Czene, Kamila; Daly, Mary B.; Demerath, Ellen W.; Dennis, Joe; Devilee, Peter; De Vivo, Immaculata; Doerk, Thilo; Dunning, Alison M.; Dwek, Miriam; Eriksson, Johan G.; Fasching, Peter A.; Fernandez-Rhodes, Lindsay; Ferreli, Liana; Fletcher, Olivia; Gago-Dominguez, Manuela; Garcia-Closas, Montserrat; Garcia-Saenz, Jose A.; Gonzalez-Neira, Anna; Grallert, Harald; Guenel, Pascal; Haiman, Christopher A.; Hall, Per; Hamann, Ute; Hakonarson, Hakon; Hart, Roger J.; Hickey, Martha; Hooning, Maartje J.; Hoppe, Reiner; Hopper, John L.; Hottenga, Jouke-Jan; Hu, Frank B.; Huebner, Hanna; Hunter, David J.; Jernstrom, Helena; John, Esther M.; Karasik, David; Khusnutdinova, Elza K.; Kristensen, Vessela N.; Lacey, James V.; Lambrechts, Diether; Launer, Lenore J.; Lind, Penelope A.; Lindblom, Annika; Magnusson, Patrik K. E.; Mannermaa, Arto; McCarthy, Mark I.; Meitinger, Thomas; Menni, Cristina; Michailidou, Kyriaki; Millwood, Iona Y.; Milne, Roger L.; Montgomery, Grant W.; Nevanlinna, Heli; Nolte, Ilja M.; Nyholt, Dale R.; Obi, Nadia; O'Brien, Katie M.; Offit, Kenneth; Oldehinkel, Albertine J.; Ostrowski, Sisse R.; Palotie, Aarno; Pedersen, Ole B.; Peters, Annette; Pianigiani, Giulia; Plaseska-Karanfilska, Dijana; Pouta, Anneli; Pozarickij, Alfred; Radice, Paolo; Rennert, Gad; Rosendaal, Frits R.; Ruggiero, Daniela; Saloustros, Emmanouil; Sandler, Dale P.; Schipf, Sabine; Schmidt, Carsten O.; Schmidt, Marjanka K.; Small, Kerrin; Spedicati, Beatrice; Stampfer, Meir; Stone, Jennifer; Tamimi, Rulla M.; Teras, Lauren R.; Tikkanen, Emmi; Turman, Constance; Vachon, Celine M.; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Zemel, Babette S.; Zheng, Wei; van Dijk, Ko W.; Alizadeh, Behrooz Z.; Bandinelli, Stefania; Boerwinkle, Eric; Boomsma, Dorret I.; Ciullo, Marina; Chenevix-Trench, Georgia; Cucca, Francesco; Esko, Tonu; Gieger, Christian; Grant, Struan F. A.; Gudnason, Vilmundur; Hayward, Caroline; Kolcic, Ivana; Kraft, Peter; Lawlor, Deborah A.; Martin, Nicholas G.; Nohr, Ellen A.; Pedersen, Nancy L.; Pennell, Craig E.; Ridker, Paul M.; Robino, Antonietta; Snieder, Harold; Sovio, Ulla; Spector, Tim D.; Stockl, Doris; Sudlow, Cathie; Timpson, Nic J.; Toniolo, Daniela; Uitterlinden, Andre; Ulivi, Sheila; Volzke, Henry; Wareham, Nicholas J.; Widen, Elisabeth; Wilson, James F.; Pharoah, Paul D. P.; Li, Liming; Easton, Douglas F.; Njolstad, Pal R.; Sulem, Patrick; Murabito, Joanne M.; Murray, Anna; Manousaki, Despoina; Juul, Anders; Erikstrup, Christian; Stefansson, Kari; Horikoshi, Momoko; Chen, Zhengming; Farooqi, I. Sadaf; Pitteloud, Nelly; Johansson, Stefan; Day, Felix R.; Perry, John R. B.; Ong, Ken K.
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes
NATURE MEDICINE
IF50
2024-05-215
OAAI
Pekayvaz, Kami; Losert, Corinna; Knottenberg, Viktoria; Gold, Christoph; van Blokland, Irene V.; Oelen, Roy; Groot, Hilde E.; Benjamins, Jan Walter; Brambs, Sophia; Kaiser, Rainer; Gottschlich, Adrian; Hoffmann, Gordon Victor; Eivers, Luke; Martinez-Navarro, Alejandro; Bruns, Nils; Stiller, Susanne; Akgoel, Sezer; Yue, Keyang; Polewka, Vivien; Escaig, Raphael; Joppich, Markus; Janjic, Aleksandar; Popp, Oliver; Kobold, Sebastian; Petzold, Tobias; Zimmer, Ralf; Enard, Wolfgang; Saar, Kathrin; Mertins, Philipp; Huebner, Norbert; van der Harst, Pim; Franke, Lude H.; van der Wijst, Monique G. P.; Massberg, Steffen; Heinig, Matthias; Nicolai, Leo; Stark, Konstantin
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases

脑表达数量性状基因座和网络分析揭示了脑相关疾病的下游效应和推定驱动因素

NATURE GENETICS
IF31.8
2023-02-2359
OAAI
de Klein, Niek; Tsai, Ellen A.; Vochteloo, Martijn; Baird, Denis; Huang, Yunfeng; Chen, Chia-Yen; van Dam, Sipko; Oelen, Roy; Deelen, Patrick; Bakker, Olivier B.; El Garwany, Omar; Ouyang, Zhengyu; Marshall, Eric E.; Zavodszky, Maria I.; van Rheenen, Wouter; Bakker, Mark K.; Veldink, Jan; Gaunt, Tom R.; Runz, Heiko; Franke, Lude; Westra, Harm-Jan
KidneyNetwork: using kidney-derived gene expression data to predict and prioritize novel genes involved in kidney disease
EUROPEAN JOURNAL OF HUMAN GENETICS
IF4.6
2023-02-207
OAAI
Boulogne, Floranne; Claus, Laura R.; Wiersma, Henry; Oelen, Roy; Schukking, Floor; de Klein, Niek; Li, Shuang; Westra, Harm-Jan; van der Zwaag, Bert; van Reekum, Franka; Sierks, Dana; Schoenauer, Ria; Li, Zhigui; Bijlsma, Emilia K.; Bos, Willem Jan W.; Halbritter, Jan; Knoers, Nine V. A. M.; Besse, Whitney; Deelen, Patrick; Franke, Lude; van Eerde, Albertien M.

研究方向

暂未获取到该数据
C
Cisca Wijmenga
H 指数:169论文数:1,001被引数:13.1万
H
Harm-Jan Westra
H 指数:55论文数:187被引数:3.3万
A
Alexandra Zhernakova
H 指数:98论文数:392被引数:5.6万
A
André G. Uitterlinden
H 指数:234论文数:2,027被引数:25.0万
T
Tōnu Esko
H 指数:165论文数:827被引数:15.7万
C
Cornelia M. van Duijn
H 指数:238论文数:1,932被引数:25.1万
D
Dorret I. Boomsma
H 指数:202论文数:2,356被引数:18.4万
M
Morris A. Swertz
H 指数:87论文数:425被引数:6.3万
P
Patrick Deelen
H 指数:60论文数:195被引数:1.9万
G
Grant W. Montgomery
H 指数:188论文数:1,236被引数:15.6万