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Yuzhuang Fu

china pharmaceutical university

H指数:7

被引数:207

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Natural and Engineered Regioselective O-Demethylation with Enantioselective Substrate Recognition by Fe(II)/2-Oxoglutarate-Dependent Oxygenases in Corydalmine Biosynthesis

天然与工程改造的位选择性O-脱甲基化及底物对映选择性识别，由Corydalmine生物合成中的Fe(II)/2-氧戊二酸依赖性氧酶介导

IF13.1

2026-04-100

PRE

Multiscale Simulations Reveal Distal Allosteric Reprogramming of Pocket Dynamics and Dual Hydrolytic Pathways in Engineered Methyl Parathion Hydrolase

多尺度模拟揭示工程甲基对硫磷水解酶口袋动力学的远程别构重编程和双重水解途径

Journal of Physical Chemistry B

IF2.9

2026-04-010

PRE

Enzymatic formation of endoperoxide by Fe(II)/α-KG-dependent dioxygenase NvfI: Insight into substrate-assisted activation of the distant C–H bond and incorporation of two oxygen molecules

Fe(II)/α-KG依赖性双加氧酶NvfI催化的内过氧化物形成：对底物辅助激活远程C–H键及两个氧分子插入的见解

Chinese Journal of Catalysis

IF17.7

2026-02-110

PRE

Degradation of Novichok nerve agent A234 by phosphotriesterase: insight into the pH-regulated mechanism from QM/MM and MM MD simulations

phys. chem. chem. phys.

IF0

2026-01-260

PRE

Biosynthesis of γ-Alkylidenebutenolide Derivatives Reveals an Atom-Deleting Lactone Ring Contraction by Dual-Enzyme Cascade

γ-烷基idenbutenolide衍生物的生物合成揭示了由双酶级联催化的原子删除内酯环收缩反应。

Journal of the American Chemical Society

IF15.6

2025-11-030

PRE

Mechanistic insights into nerve agent VX detoxification by engineered phosphotriesterase

对工程化磷三酯酶介导的神经毒剂VX解毒机制的见解

Biochemical and Biophysical Research Communications

IF2.2

2025-07-040

PRE

A Dual-Focus Workflow for Simultaneously Engineering High Activity and Thermal Stability in Methyl Parathion Hydrolase

在甲基对硫磷水解酶中同时设计高活性和热稳定性的双焦点工作流程

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2024-10-081

OA

Coordination dynamics of iron center enables the C-H bond activation: QM/MM insight into the catalysis of hydroxyglutarate synthase (HglS)

JOURNAL OF CATALYSIS

IF6.5

2023-12-016

PRE

Biodegradation of 2,5-Dihydroxypyridine by 2,5-Dihydroxypyridine Dioxygenase and Its Mutants: Insights into O-O Bond Activation and Flexible Reaction Mechanisms from QM/MM Simulations

INORGANIC CHEMISTRY

IF4.7

2022-12-054

PRE

Water-Regulated Mechanisms for Degradation of Pesticides Paraoxon and Parathion by Phosphotriesterase: Insight from QM/MM and MD Simulations

磷酸三酯酶降解农药对氧磷和对硫磷的水调节机制: 来自QM/MM和MD模拟的见解

CHEMISTRY-AN ASIAN JOURNAL

IF3.3

2022-05-318

PRE

Conformational Change of H64 and Substrate Transportation: Insight Into a Full Picture of Enzymatic Hydration of CO2 by Carbonic Anhydrase

FRONTIERS IN CHEMISTRY

IF4.2

2021-07-0910

OAAI

Hydrogen- and Halogen-Bonds between Ions of like Charges: Are They Anti-Electrostatic in Nature?

类似电荷的离子之间的氢键和卤素键: 它们本质上是抗静电的吗？

JOURNAL OF COMPUTATIONAL CHEMISTRY

IF4.8

2017-09-2653

PREAI