方

方亮 (Liang Fang)

Weifang University研究副教授

H指数:4

被引数:233

个人简介

"研究领域我的研究聚焦于基因调控机制的探索及其在生物发育和相关疾病（特别是癌症）中的作用。该研究具备高度的跨学科属性，融合了分子生物学、基因组学、表观遗传学与生物工程学等多学科的方法与视野。核心研究围绕开发并应用一系列创新工具展开，包括高通量筛选、单细胞多组学技术及基于CRISPR的基因编辑策略，以解决重要的基础生物学问题。相关研究已在《Nature Communications》《Cancer Research》等学术期刊上发表，这些成果也反映出我在推动转录后调控、染色质重塑及细胞异质性等领域的科学理解方面所做的持续努力与贡献。学术成果查看更多 2025 Sun, Z.*, X. Wen*, Y. Li, X. Xie, P. Dong, Y. Shu, S. Tian, J. Yang, Y. Lin, M. Wang, F. Jiang, Q. Zhu, H. Cui, J. Zhai, Y. Hu, L. Fang# and W. Chen# (2025). “Systematic characterization of the composition and dynamics of processing body-associated mRNAs.” Nat Commun 16(1): 9867. Cui, H.*#, W. Liang*, Z. Shi*, L. Zhang*, G. Li, R. Chen, C. Tian, D. Gan, X. Shi, Z. Sun, Q. Zhu, L. Fang, H. Huang, Y. Hu, Y. Chen and W. Chen# (2025). “CANTAC-seq analysis reveals E2f1 and Otx1 coordinate zygotic genome activation in Xenopus tropicalis.” Nature Communications 16(1): 10101. 2024 Sadeghzade, S., J. Cao, R. Yang, Y. Li, Y. Li, D. Zhang, J. Liu, Z. Yu, L. Fang and H. Yuan (2024). “Highly stretchable alginate/methylcellulose hydrogels for 3D bio-printing: photopolymerization approach enhancing structural integrity.” Giant 18: 100280. Feng, L., W. Yan, X. Tang, H. Wu, Y. Pan, D. Lu, Q. Ling-Hu, Y. Liu, Y. Liu, X. Song, M. Ali, L. Fang, H. Guo and B. Li (2024). “Multiple factors and features dictate the selective production of ct-siRNA in Arabidopsis.” Commun Biol 7(1): 474. Fang, L.*#, L. Zhang*, M. Wang*, Y. He, J. Yang, Z. Huang, Y. Tan, K. Fang, J. Li, Z. Sun, Y. Li, Y. Tang, W. Liang, H. Cui, Q. Zhu, Z. Wu, Y. Li, Y. Hu and W. Chen# (2024). “Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition.” Cancer Res 84(5): 659-674. Chen, R., X. Shi, X. Yao, T. Gao, G. Huang, D. Ning, Z. Cao, Y. Xu, W. Liang, S. Z. Tian, Q. Zhu, L. Fang, M. Zheng, Y. Hu, H. Cui# and W. Chen# (2024). “Specific multivalent molecules boost CRISPR-mediated transcriptional activation.” Nat Commun 15(1): 7222. 2023 Zhu, Q.*#, X. Zhao*, Y. Zhang*, Y. Li*, S. Liu*, J. Han, Z. Sun, C. Wang, D. Deng, S. Wang, Y. Tang, Y. Huang, S. Jiang, C. Tian, X. Chen, Y. Yuan, Z. Li, T. Yang, T. Lai, Y. Liu, W. Yang, X. Zou, M. Zhang, H. Cui, C. Liu, X. Jin, Y. Hu, A. Chen, X. Xu, G. Li, Y. Hou, L. Liu#, S. Liu#, L. Fang#, W. Chen# and L. Wu# (2023). “Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines.” Nat Commun 14(1): 8170. Song, X., P. Guo, K. Xia, M. Wang, Y. Liu, L. Chen, J. Zhang, M. Xu, N. Liu, Z. Yue, X. Xu, Y. Gu, G. Li, M. Liu, L. Fang, X. W. Deng and B. Li (2023). “Spatial transcriptomics reveals light-induced chlorenchyma cells involved in promoting shoot regeneration in tomato callus.” Proc Natl Acad Sci U S A 120(38): e2310163120. 2022 Yang, C., Y. Liu, Y. Hu, L. Fang, Z. Huang, H. Cui, J. Xie, Y. Hong, W. Chen, N. Xiao, Q. Li, W.-H. Liu and C. Xiao (2022). “Myc inhibition tips the immune balance to promote antitumor immunity.” Cellular & Molecular Immunology. Wang, W., H. Huang, H. Jiang, C. Tian, Y. Tang, D. Gan, X. Wen, Z. Song, Y. He, X. Ou and L. Fang (2022). “A Cross-Tissue Investigation of Molecular Targets and Physiological Functions of Nsun6 Using Knockout Mice.” Int J Mol Sci 23(12). Cui, H., H. Yi, H. Bao, Y. Tan, C. Tian, X. Shi, D. Gan, B. Zhang, W. Liang, R. Chen, Q. Zhu, L. Fang, X. Gao, H. Huang, R. Tian, S. R. Sperling, Y. Hu and W. Chen (2022). “The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-beta signaling.” Nat Commun 13(1): 4680. Zou, X., B. Schaefke, Y. Li, F. Jia, W. Sun, G. Li, W. Liang, T. Reif, F. Heyd, Q. Gao, S. Tian, Y. Li, Y. Tang, L. Fang, Y. Hu and W. Chen (2022). “Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law.” Life Sci Alliance 5(4). Wang, D., Q. Mai, X. Yang, X. Chi, R. Li, J. Jiang, L. Luo, X. Fang, P. Yun, L. Liang, G. Yang, K. Song, L. Fang, Y. Chen, Y. Zhang, Y. He, N. Li and Y. Pan (2022). “Microduplication of 16p11.2 locus Potentiates Hypertrophic Obesity in Association with Imbalanced Triglyceride Metabolism in White Adipose Tissue.” Mol Nutr Food Res 66(5): e2100241. Tian, S., B. Zhang, Y. He, Z. Sun, J. Li, Y. Li, H. Yi, Y. Zhao, X. Zou, Y. Li, H. Cui, L. Fang, X. Gao, Y. Hu and W. Chen (2022). “CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference.” Nucleic Acids Res 50(5): e26. Gao, X., J. You, Y. Gong, M. Yuan, H. Zhu, L. Fang, H. Zhu, M. Ying, Q. He, B. Yang and J. Cao (2022). “WSB1 regulates c-Myc expression through beta-catenin signaling and forms a feedforward circuit.” Acta Pharm Sin B 12(3): 1225-1239. 2021 Zhou, P., Y. Qi, X. Fang, M. Yang, S. Zheng, C. Liao, F. Qin, L. Liu, H. Li, Y. Li, E. Ravindran, C. Sun, X. Wei, W. Wang, L. Fang, D. Han, C. Peng, W. Chen, N. Li, A. M. Kaindl and H. Hu (2021). “Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m(6)A-methylation of Npdc1 and Cend1.” iScience 24(6): 102645. Long, Y., Z. Liu, J. Jia, W. Mo, L. Fang, D. Lu, B. Liu, H. Zhang, W. Chen and J. Zhai (2021). “FlsnRNA-seq: protoplasting-free full-length single-nucleus RNA profiling in plants.” Genome Biol 22(1): 66. Kamdem, N., Y. Roske, D. Kovalskyy, M. O. Platonov, O. Balinskyi, A. Kreuchwig, J. Saupe, L. Fang, A. Diehl, P. Schmieder, G. Krause, J. Rademann, U. Heinemann, W. Birchmeier and H. Oschkinat (2021). “Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.” Magn. Reson. 2(1): 355-374. Fang, L.*#, G. Li#, Z. Sun, Q. Zhu, H. Cui, Y. Li, J. Zhang, W. Liang, W. Wei, Y. Hu and W. Chen* (2021). “CASB: a concanavalin A-based sample barcoding strategy for single-cell sequencing.” Mol Syst Biol 17(4): e10060. Wu, X., Y. Zheng, M. Liu, Y. Li, S. Ma, W. Tang, W. Yan, M. Cao, W. Zheng, L. Jiang, J. Wu, F. Han, Z. Qin, L. Fang, W. Hu, Z. Chen* and X. Zhang* (2021). “BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains.” Autophagy 17(8): 1934-1946. 2020 Fang, L.*#, W. Wang#, G. Li#, L. Zhang, J. Li, D. Gan, J. Yang, Y."