李子杰 (Zijie Li)

jiangnan university副主任

H指数:19

被引数:1,495

个人简介

"长期从事功能糖的合成生物学与酶催化工程研究，主要承担糖生物工程、系统生物学与生物合成前沿等课程的讲授工作，获校级教学成果二等奖2项。以第一/通讯作者发表SCI论文35篇；授权国家发明专利16件；主持国家自然科学面上/青年基金、国家重点研发子课题、中国博士后面上基金、企业横向等项目；食品科学技术学报青年编委，江苏省科技副总特聘专家（2022），江南大学本科优秀毕业论文指导教师，江南大学本科生优秀班主任，指导学生获得包括全国大学生生命科学竞赛国家一等奖在内的国家级奖项6项。\n学习工作经历点击展开\n2007-2012 山东大学国家糖工程中心，微生物学专业（硕博连读），博士学位 2010-2011 美国俄亥俄州立大学，生化与化学系，博士联合培养 2011-2012 美国佐治亚州立大学，化学系，博士联合培养 2012-2016 江南大学生物工程学院，校聘副教授 2016-至今江南大学生物工程学院，糖化学与生物技术教育部重点实验室副教授 2020-至今江南大学糖化学与生物技术教育部重点实验室副主任\n主要成果点击展开\n主要代表性成果：一、期刊论文 1、Yasen Wang, Linpei Zhang, Li Li, Wanjie Li, Yahui Gao, Xiao-Dong Gao*, Zijie Li*. High-efficiency production of Lacto-N-triose II through combinatorial metabolic strategies in Saccharomyces cerevisiae. Chemical Engineering Journal. 2026, 535, 175493. 2、Li Li, Yasen Wang, Buqing Wang, Liqun Shen, Yahui Gao, Wei Lin, Zijie Li* A dCas9-integrated iLight9O system enables dynamic regulation for enhanced patchoulol biosynthesis in Saccharomyces cerevisiae. Bioresource Technology. 2026, 446, 134195. 3、Liqun Shen#, Cheng Yu#, Kangqing Fei, Yahui Gao, Bo Zhang, Zijie Li* Enhancing the catalytic efficiency of L-rhamnose isomerase for D-allose synthesis through simultaneous engineering of Noncatalytic and Catalytic Pockets, Journal of Agricultural and Food Chemistry. 2025, 73(14): 8493-8502. 4、Jiawen Bai, Yasen Wang, Wanjie Li, Chenyu Si, Zhouge Lan, Yishi Liu, Hideki Nakanishi, Zijie Li*. Development of a self-assembled dual-enzyme co-display platform on the surface of the natural \"chitosan beads\" of yeast spores. International Journal of Biological Macromolecules. 2025, 286: 138308. 5、Kangqing Fei, Zhou Chen, Liqun Shen, Xiao-Dong Gao, Hideki Nakanishi, Zijie Li*. Efficient biosynthesis of rare sugars using glycerol as a sole carbon source in metabolic engineered Bacillus subtilis.Food Bioscience. 2025, 64: 105917. 6、Chenyu Si, Jiawen Bai, Yuqing Li, Yang Li, Yishi Liu, Xiaoman Zhou, Jie Shi, Hideki Nakanishi, Zijie Li*. Establishment of a novel platform for developing oral vaccines based on the surface display system of yeast spores, International Journal of Molecular Sciences. 2025, 26(8): 3615-348. 7、Buqing Wang, Xiaoman Zhou, Yasen Wang, Yahui Gao, Hideki Nakanishi, Morihisa Fujita, Zijie Li*. Enhancement of thermostability and expression level of Rasamsonia emersonii lipase in Pichia pastoris and its application in biodiesel production in a continuous flow reactor. International Journal of Biological Macromolecules. 2024, 278: 134481. 8、Zijie Li*, Yangfan Hu, Cheng Yu, Kangqing Fei, Liqun Shen, Yishi Liu, Hideki Nakanishi. Semi-rational engineering of D-allulose 3-epimerase for simultaneously improving the catalytic activity and thermostability based on D-allulose biosensor. Biotechnology Journal. 2024, 19(8): e2400280 9、Buqing Wang, Yasen Wang, Xiaoman Zhou, Xiao-Dong Gao, Morihisa Fujita, Zijie Li*. Highly efficient expression of Rasamsonia emersonii lipase in Pichia pastoris: characterization and gastrointestinal simulated digestion in vitro. Journal of the Science of Food and Agriculture. 2024, 104(9): 5603-5613 10、Kangqing Fei, Liqun Shen, Xiao-Dong Gao, Hideki Nakanishi*, Zijie Li* Multienzyme cascade synthesis of rare sugars from glycerol in Bacillus subtilis, Biotechnology Journal. 2024, 19(12), e202400539. 11、Hui-Lin Xu, Xiaoman Zhou, Shuai Chen, Si Xu, Zijie Li*, Hideki Nakanishi* and Xiao-Dong Gao*. Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism. Communications Biology. 2023, 6, 259. 12、Zijie Li*, Linxue Feng, Zhou Chen, Yangfan Hu, Kangqing Fei, Huilin Xu, Xiao-Dong Gao*. Efficient enzymatic synthesis of D-allulose using a novel D-allulose-3-epimerase from Caballeronia insecticola. Journal of the Science of Food and Agriculture. 2023, 103, 339-348. 13、Yasen Wang, Buqing Wang, Yahui Gao, Hideki Nakanishi, Xiao-Dong Gao, Zijie Li*. Highly efficient expression and secretion of human lysozyme using multiple strategies in Pichia pastoris, Biotechnology Journal. 2023, 18, 2300259. 14、Zijie Li#*, Wanjie Li#, Yasen Wang, Zhou Chen, Hideki Nakanishi, Xiangyang Xu, Xiao-Dong Gao*. Establishment of a novel cell surface display platform based on natural \"Chitosan Beads\" of yeast spores. Journal of Agricultural and Food Chemistry. 2022, 70(24), 7479-7489 (封面). 15、Zhou Chen, Xiao-Dong Gao, Zijie Li*. Recent advances regarding the physiological functions and biosynthesis of D-allulose. Frontiers in Microbiology. 2022, 13, 881037. 16、Shijie Fu#, Yanting Dang#, Huilin Xu, Aimin Li, Xiaoman Zhou, Xiao-Dong Gao, Zijie Li*. Aloe vera-fermented beverage ameliorates obesity and gut dysbiosis in high-fat-diet mice. Foods. 2022, 11, 3728. 17、Qiang Chao, Tianlu Li, Jixiang Jia, Zijie Li, Peng Peng, Xiao-Dong Gao*, Ning Wang*. Spore-encapsulating glycosyltransferase catalysis tandem reactions: facile chemoenzymatic synthesis of complex human glycans. ACS Catalysis. 2022, 12, 3181-3188. 18、Zhou Chen, Kangqing Fei, Yangfan Hu, Xiangyang Xu, Xiao-Dong Gao, Zijie Li*. Identification of a novel alditol oxidase from Thermopolyspora flexuosa with potential application in D-glyceric acid production. Molecular Biotechnology. 2022, 64(7), 804-813. 19、Zijie Li, Xiaoxiao Liu, Hideki Nakanishi, Xiao-Dong Gao*. Encapsulation of mannose-6-phosphate isomerase in yeast spores and its application in L-ribose production. Journal of Agricultural and Food Chemistry. 2020, 68(25), 6892-6899. 20、Zijie Li*#, Fen Li#, Li Cai, Zhou Chen, Ling Qin, Xiao-Dong Gao*. One-pot multienzyme synthesis of rare ketoses from glycerol. Journal of Agricultural and Food Chemistry. 2020, 68(5), 1347-1353. 21、Zhou Chen, Zijie Li*, Fen Li, Mayan Wang, Ning Wang, Xiao-Dong Gao*. Cascade synthesis of rare ketoses by whole cells based on L-rhamnulose-1-phosphate aldolase. Enzyme and Microbial Technology. 2020,133:109456. 22、Zhou Chen, Zijie Li*, Fen Li, Ning Wang, Xiao-Dong Gao*. Characterization of alditol oxidase from Streptomyces coelicolor and its application in the production of rare sugars. Bioorganic & Medicinal Chemistry. 2020, 28 (10), 115"