未登录Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes
Bonazzi, Simone; Gray, Audrey; Thomsen, Noel M.; Biag, Jonathan; Labbe-Giguere, Nancy; Keaney, Erin P.; Malik, Hasnain A.; Sun, Yingchuan; Nunez, Jill; Karki, Rajeshri G.; Knapp, Mark; Elling, Robert; Fuller, John; Pardee, Gwynn; Craig, Lucas; Capre, Ketthsy; Salas, Sarah; Gorde, Aakruti; Liang, Guiqing; Lubicka, Danuta; McTighe, Stephanie M.; Goold, Carleton; Liu, Shanming; Deng, Lin; Hong, Jin; Fekete, Alexander; Stadelmann, Pascal; Frieauff, Wilfried; Elhajouji, Azeddine; Bauer, Daniel; Lerchner, Andreas; Radetich, Branko; Furet, Pascal; Piizzi, Grazia; Burdette, Doug; Wilson, Christopher J.; Peukert, Stefan; Hamann, Lawrence G.; Murphy, Leon O.; Curtis, Daniel .png)
分享.png)
收藏分享 收藏 The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition第一类小分子通过直接竞争有效破坏yap-tead相互作用Furet, Pascal; Bordas, Vincent; Le Douget, Mickael; Salem, Bahaa; Mesrouze, Yannick; Imbach-Weese, Patricia; Sellner, Holger; Voegtle, Markus; Soldermann, Nicolas; Chapeau, Emilie; Wartmann, Markus; Scheufler, Clemens; Fernandez, Cesar; Kallen, Joerg; Guagnano, Vito; Chene, Patrick; Schmelzle, Tobias 分享 收藏 Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase InhibitorFairhurst, Robin A.; Furet, Pascal; Imbach-Weese, Patricia; Stauffer, Frederic; Rueeger, Heinrich; McCarthy, Clive; Ripoche, Sebastien; Oswald, Susanne; Arnaud, Bertrand; Jary, Aline; Maira, Michel; Schnell, Christian; Guthy, Daniel A.; Wartmann, Markus; Kiffe, Michael; Desrayaud, Sandrine; Blasco, Francesca; Widmer, Toni; Seiler, Frank; Gutmann, Sascha; Knapp, Mark; Caravatti, Giorgio 分享 收藏 p53 dynamics vary between tissues and are linked with radiation sensitivityp53动力学因组织而异，并与辐射敏感性有关Stewart-Ornstein, Jacob; Iwamoto, Yoshiko; Miller, Miles A.; Prytyskach, Mark A.; Ferretti, Stephane; Holzer, Philipp; Kallen, Joerg; Furet, Pascal; Jambhekar, Ashwini; Forrester, William C.; Weissleder, Ralph; Lahav, Galit 分享 收藏 Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4Fairhurst, Robin A.; Knoepfel, Thomas; Buschmann, Nicole; Leblanc, Catherine; Mah, Robert; Todorov, Milen; Nimsgern, Pierre; Ripoche, Sebastien; Niklaus, Michel; Warin, Nicolas; Van Huy Luu; Madoerin, Mario; Wirth, Jasmin; Graus-Porta, Diana; Weiss, Andreas; Kiffe, Michael; Wartmann, Markus; Kinyamu-Akunda, Jacqueline; Sterker, Dario; Stamm, Christelle; Adler, Flavia; Buhles, Alexandra; Schadt, Heiko; Couttet, Philippe; Blank, Jutta; Galuba, Inga; Trappe, Jorg; Voshol, Johannes; Ostermann, Nils; Zou, Chao; Berghausen, Jorg; Espinola, Alberto Del Rio; Jahnke, Wolfgang; Furet, Pascal 分享 收藏 Molecular and structural characterization of a TEAD mutation at the origin of Sveinssons chorioretinal atrophyBokhovchuk, Fedir; Mesrouze, Yannick; Izaac, Aude; Meyerhofer, Marco; Zimmermann, Catherine; Fontana, Patrizia; Schmelzle, Tobias; Erdmann, Dirk; Furet, Pascal; Kallen, Joerg; Chene, Patrick 分享 收藏 FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular CancerFGF401，一种用于治疗FGF19-Driven肝细胞癌的一流的高选择性和有效的FGFR4抑制剂Weiss, Andreas; Adler, Flavia; Buhles, Alexandra; Stamm, Christelle; Fairhurst, Robin A.; Kiffe, Michael; Sterker, Dario; Centeleghe, Mario; Wartmann, Markus; Kinyamu-Akunda, Jacqueline; Schadt, Heiko S.; Couttet, Philippe; Wolf, Armin; Wang, Youzhen; Barzaghi-Rinaudo, Patrizia; Murakami, Masato; Kauffmann, Audrey; Knoepfel, Thomas; Buschmann, Nicole; Leblanc, Catherine; Mah, Robert; Furet, Pascal; Blank, Jutta; Hofmann, Francesco; Sellers, William R.; Porta, Diana Graus 分享 收藏 Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound ClassesKallen, Joerg; Izaac, Aude; Chau, Suzanne; Wirth, Emmanuelle; Schoepfer, Joseph; Mah, Robert; Schlapbach, Achim; Stutz, Stefan; Vaupel, Andrea; Guagnano, Vito; Masuya, Keiichi; Stachyra, Therese-Marie; Salem, Bahaa; Chene, Patrick; Gessier, Francois; Holzer, Philipp; Furet, Pascal 分享 收藏 Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophyBokhovchuk, Fedir; Mesrouze, Yannick; Izaac, Aude; Meyerhofer, Marco; Zimmermann, Catherine; Fontana, Patrizia; Schmelzle, Tobias; Erdmann, Dirk; Furet, Pascal; Kallen, Joerg; Chene, Patrick 分享 收藏 Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201Jeay, Sebastien; Ferretti, Stephane; Holzer, Philipp; Fuchs, Jeanette; Chapeau, Emilie A.; Wartmann, Markus; Sterker, Dario; Romanet, Vincent; Murakami, Masato; Kerr, Grainne; Durand, Eric Y.; Gaulis, Swann; Cortes-Cros, Marta; Ruetz, Stephan; Stachyra, Therese-Marie; Kallen, Joerg; Furet, Pascal; Wurthner, Jens; Guerreiro, Nelson; Halilovic, Ensar; Jullion, Astrid; Kauffmann, Audrey; Kuriakose, Emil; Wiesmann, Marion; Jensen, Michael R.; Hofmann, Francesco; Sellers, William R. 分享 收藏 2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 42-甲酰基吡啶脲作为成纤维细胞生长因子受体4的高选择性可逆共价抑制剂Knoepfel, Thomas; Furet, Pascal; Mah, Robert; Buschmann, Nicole; Leblanc, Catherine; Ripoche, Sebastien; Graus-Porta, Diana; Wartmann, Markus; Galuba, Inga; Fairhurst, Robin A. 分享 收藏 Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in FGFR2 fusion-positive cholangiocarcinoma patientsGoyal, Lipika; Saha, Supriya K.; Liu, Leah Y.; Siravegna, Giulia; Leshchiner, Ignaty; Ahronian, Leanne G.; Lennerz, Jochen K.; Phuong Vu; Mussolin, Benedetta; Reyes, Stephanie; Furet, Pascal; Iafrate, A. John; Getz, Gad; Porta, Diana G.; Tiedt, Ralph; Bardelli, Alberto; Juric, Dejan; Corcoran, Ryan B.; Bardeesy, Nabeel; Zhu, Andrew X. 分享 收藏 Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive CholangiocarcinomaGoyal, Lipika; Saha, Supriya K.; Liu, Leah Y.; Siravegna, Giulia; Leshchiner, Ignaty; Ahronian, Leanne G.; Lennerz, Jochen K.; Vu, Phuong; Deshpande, Vikram; Kambadakone, Avinash; Mussolin, Benedetta; Reyes, Stephanie; Henderson, Laura; Sun, Jiaoyuan Elisabeth; Van Seventer, Emily E.; Gurski, Joseph M., Jr.; Baltschukat, Sabrina; Schacher-Engstler, Barbara; Barys, Louise; Stamm, Christelle; Furet, Pascal; Ryan, David P.; Stone, James R.; Iafrate, A. John; Getz, Gad; Porta, Diana Graus; Tiedt, Ralph; Bardelli, Alberto; Juric, Dejan; Corcoran, Ryan B.; Bardeesy, Nabeel; Zhu, Andrew X. 分享 收藏 Bioorthogonal Probes for the Study of MDM2-p53 Inhibitors in Cells and Development of High-Content Screening Assays for Drug DiscoveryD'Alessandro, Pier Luca; Buschmann, Nicole; Kaufmann, Markus; Furet, Pascal; Baysang, Frederic; Brunner, Reto; Marzinzik, Andreas; Vorherr, Thomas; Stachyra, Therese-Marie; Ottl, Johannes; Lizos, Dimitrios E.; Cobos-Correa, Amanda 分享 收藏 NVP-HDM201: Biochemical and biophysical profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2Stachyra-Valat, Therese; Baysang, Frederic; D'Alessandro, Anne-Cecile; Dirk, Erdmann; Furet, Pascal; Guagnano, Vito; Kallen, Joerg; Leder, Lukas; Mah, Robert; Masuya, Keiichi; Stutz, Stefan; Vaupel, Andrea; Hofmann, Francesco; Cherie, Patrick; Jeay, Sebastien; Holzer, Philipp 分享 收藏 NVP-HDM201: cellular and in vivo profile of a novel highly potent and selective PPI inhibitor of p53 Mdm2Jeay, Sebastien; Chene, Patrick; Ferretti, Stephane; Furet, Pascal; Gruenenfelder, Bjoern; Guagnano, Vito; Guerreiro, Nelson; Halilovic, Ensar; Hofmann, Francesco; Kellen, Joerg; Leonard, Michelle; Mah, Robert; Masuya, Keiichi; Ramos, Rita; Rynn, Caroline; Ruetz, Stephan; Stachyra-Valat, Therese; Stutz, Stefan; Vaupel, Andrea; Wuerthner, Jens; Holzer, Philipp 分享 收藏 Discovery of NVP-HDM201-First disclosure of a Next-Generation Mdm2 inhibitor with superior characteristicsHolzer, Philipp; Chene, Patrick; Ferretti, Stephane; Furet, Pascal; Gabriel, Tobias; Gruenenfelder, Bjoern; Guagnano, Vito; Hofmann, Francesco; Kellen, Joerg; Mah, Robert; Masuya, Keiichi; Ramos, Rita; Ruetz, Stephan; Rynn, Caroline; Stachyra-Valat, Therese; Stutz, Stefan; Vaupel, Andrea; Jeay, Sebastien 分享 收藏 Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective InhibitorsHoegenauer, Klemens; Soldermann, Nicolas; Stauffer, Frederic; Furet, Pascal; Graveleau, Nadege; Smith, Alexander B.; Hebach, Christina; Hollingworth, Gregory J.; Lewis, Ian; Gutmann, Sascha; Rummel, Gabriele; Knapp, Mark; Wolf, Romain M.; Blanz, Joachim; Feifel, Roland; Burkhart, Christoph; Zecri, Frederic 分享 收藏 A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting AngiogenesisBold, Guido; Schnell, Christian; Furet, Pascal; McSheehy, Paul; Brueggen, Josef; Mestan, Juergen; Manley, Paul W.; Drueckes, Peter; Burglin, Marion; Duerler, Ursula; Loretan, Jacqueline; Reuter, Robert; Wartmann, Markus; Theuer, Andreas; Bauer-Probst, Beatrice; Martiny-Baron, Georg; Allegrini, Peter; Goepfert, Arnaud; Wood, Jeanette; Littlewood-Evans, Amanda 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
