未登录In Silico-Enabled Discovery and Development of Potent and Selective CDK11 Inhibitors基于计算机的强效且选择性CDK11抑制剂的发现与开发
Mak, Frankie S.; Ng, Fui Mee; Anbazhagan, Padmanabhan; Madan, Vikas; Tan, Qian Wen; See, Yiyang; Lim, Diane; Kusuma, Frances Karla; Toh, Hannah; Mohammad, Juliana; Yang, Haiyan; Sim, Sandra; Tan, Li Hong; Tay, Eileen; Hai, Ronald Toh Kuan; Kwek, Perlyn Zekui; Wong, Mei Yee; Raman, Deepika; Ang, Qi An; Manoharan, Vithya; Vuddagiri, Susmitha; Dawson, Monique Danielle; Tan, Alison; Joy, Joma Kanikadu; Gan, Bong Hwa; Low, Choon Bing; Xu, Haoying; Lim, Siew Pheng; Hentze, Hannes; Cherian, Joseph; Tan, Chong Teik; Ang, Jackie; Ethirajulu, Kantharaj; Foo, Klement; Singh, Inderjeet; Xu, Weijun .png)
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收藏分享 收藏 NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal modelsNITD-688是登革热病毒NS4B蛋白的泛血清型抑制剂，在临床前动物模型中显示出良好的药代动力学和疗效Moquin, Stephanie A.; Simon, Oliver; Karuna, Ratna; Lakshminarayana, Suresh B.; Yokokawa, Fumiaki; Wang, Feng; Saravanan, Chandra; Zhang, Jin; Day, Craig W.; Chan, Katherine; Wang, Qing-Yin; Lu, Siyan; Dong, Hongping; Wan, Kah Fei; Lim, Siew Pheng; Liu, Wei; Seh, Cheah Chen; Chen, Yen-Liang; Xu, Haoying; Barkan, David T.; Kounde, Cyrille S.; Sim, Wei Lin Sandra; Wang, Gang; Yeo, Hui-Quan; Zou, Bin; Chan, Wai Ling; Ding, Mei; Song, Jae-Geun; Li, Min; Osborne, Colin; Blasco, Francesca; Sarko, Christopher; Beer, David; Bonamy, Ghislain M. C.; Sasseville, Vito G.; Shi, Pei-Yong; Diagana, Thierry T.; Yeung, Bryan K. S.; Gu, Feng 分享 收藏 Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional StudiesArora, Rishi; Liew, Chong Wai; Soh, Tingjin Sherryl; Otoo, Dorcas Adobea; Seh, Cheah Chen; Yue, Kimberley; Nilar, Shahul; Wang, Gang; Yokokawa, Fumiaki; Noble, Christian G.; Chen, Yen Liang; Shi, Pei-Yong; Lescar, Julien; Smith, Thomas M.; Benson, Timothy E.; Lim, Siew Pheng 分享 收藏 A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′-C- Methylguanosine for the Treatment of Dengue Virus InfectionKaruna, Ratna; Yokokawa, Fumiaki; Wang, Keshi; Zhang, Jin; Xu, Haoying; Wang, Gang; Ding, Mei; Chan, Wai Ling; Ghafar, Nahdiyah Abdul; Leonardi, Andrea; Seh, Cheah Chen; Seah, Peck Gee; Liu, Wei; Srinivasa, Rao P. S.; Lim, Siew Pheng; Lakshminarayana, Suresh B.; Growcott, Ellie; Babu, Sreehari; Fenaux, Martijn; Zhong, Weidong; Gu, Feng; Shi, Pei-Yong; Blasco, Francesca; Chen, Yen-Liang 分享 收藏 分享 收藏 Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity RiskFenaux, Martijn; Lin, Xiaodong; Yokokawa, Fumiaki; Sweeney, Zachary; Saunders, Oliver; Xie, Lili; Lim, Siew Pheng; Uteng, Marianne; Uehara, Kyoko; Warne, Robert; Gang, Wang; Jones, Christopher; Yendluri, Satya; Gu, Helen; Mansfield, Keith; Boisclair, Julie; Heimbach, Tycho; Catoire, Alexandre; Bracken, Kathryn; Weaver, Margaret; Moser, Heinz; Zhong, Weidong 分享 收藏 Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance ProfilingLim, Siew Pheng; Noble, Christian Guy; Seh, Cheah Chen; Soh, Tingjin Sherryl; El Sahili, Abbas; Chan, Grace Kar Yarn; Lescar, Julien; Arora, Rishi; Benson, Timothy; Nilar, Shahul; Manjunatha, Ujjini; Wan, Kah Fei; Dong, Hongping; Xie, Xuping; Shi, Yong; Yokokawa, Fumiaki 分享 收藏 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure Based Drug DesignYokokawa, Fumiaki; Nilar, Shahul; Noble, Christian G.; Lim, Siew Pheng; Rao, Ranga; Tania, Stefani; Wang, Gang; Lee, Gladys; Hunziker, Juerg; Karuna, Ratna; Manjunatha, Ujjini; Shi, Pei-Yong; Smith, Paul W. 分享 收藏 A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based ScreeningNoble, Christian G.; Lim, Siew Pheng; Arora, Rishi; Yokokawa, Fumiaki; Nilar, Shahul; Seh, Cheah Chen; Wright, S. Kirk; Benson, Timothy E.; Smith, Paul W.; Shi, Pei-Yong 分享 收藏 分享 收藏 Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus ReplicationZhao, Yongqian; Soh, Tingjin Sherryl; Chan, Kitti Wing Ki; Fung, Sarah Suet Yin; Swaminathan, Kunchithapadam; Lim, Siew Pheng; Shi, Pei-Yong; Huber, Thomas; Lescar, Julien; Luo, Dahai; Vasudevan, Subhash G. 分享 收藏 A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus ReplicationZhao, Yongqian; Soh, Tingjin Sherryl; Zheng, Jie; Chan, Kitti Wing Ki; Phoo, Wint Wint; Lee, Chin Chin; Tay, Moon Y. F.; Swaminathan, Kunchithapadam; Cornvik, Tobias C.; Lim, Siew Pheng; Shi, Pei-Yong; Lescar, Julien; Vasudevan, Subhash G.; Luo, Dahai 分享 收藏 分享 收藏 Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates BalapiravirChen, Yen-Liang; Ghafar, Nahdiyah Abdul; Karuna, Ratna; Fu, Yilong; Lim, Siew Pheng; Schul, Wouter; Gu, Feng; Herve, Maxime; Yokohama, Fumiaki; Wang, Gang; Cerny, Daniela; Fink, Katja; Blasco, Francesca; Shi, Pei-Yong 分享 收藏 分享 收藏 A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation ActivitiesLim, Siew Pheng; Koh, Jolene Hong Kiew; Seh, Cheah Chen; Liew, Chong Wai; Davidson, Andrew D.; Chua, Leng Shiew; Chandrasekaran, Ramya; Cornvik, Tobias C.; Shi, Pei-Yong; Lescar, Julien 分享 收藏 分享 收藏 分享 收藏 2′-O Methylation of Internal Adenosine by Flavivirus NS5 MethyltransferaseDong, Hongping; Chang, David C.; Hua, Maggie Ho Chia; Lim, Siew Pheng; Chionh, Yok Hian; Hia, Fabian; Lee, Yie Hou; Kukkaro, Petra; Lok, Shee-Mei; Dedon, Peter C.; Shi, Pei-Yong 分享 收藏 
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