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L

Laura M. Sanz

gsk
H指数:28
被引数:4,239

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Identification of Compound 15 (MMV1581361) as a PfATP4 Inhibitor with Transmission-Blocking Activity and In Vivo Efficacy in a SCID Mouse Model of Malaria

鉴定化合物15 (MMV1581361)为一种具有阻断传播活性和SCID小鼠疟疾模型中体内效果的PfATP4抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-02-110
PRE
Henry A. Onyame; Stephen Brand; Delphin Baud; Gregory S. Basarab; Natalie Hawryluk; Stacie Canan; Magdalene D. Togoh; Ramatu Abdulai; Robert Eduku; Mohammed Awal; Richard Boakye Owoare; Barsha Chatterjee; Debasish Singha Roy; Amal Kr Ray Mahapatra; Soumyodip Bhowmik; Proyasi Putatunda; Benigno Crespo; Laura Sanz; David Calvo; Sergio Wittlin; Patrick K. Tumwebaze; Jeremy Borrows; Richard K. Amewu
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
NATURE COMMUNICATIONS
IF15.7
2022-04-2021
OAAI
de Vries, Laura E.; Jansen, Patrick A. M.; Barcelo, Catalina; Munro, Justin; Verhoef, Julie M. J.; Pasaje, Charisse Flerida A.; Rubiano, Kelly; Striepen, Josefine; Abla, Nada; Berning, Luuk; Bolscher, Judith M.; Demarta-Gatsi, Claudia; Henderson, Rob W. M.; Huijs, Tonnie; Koolen, Karin M. J.; Tumwebaze, Patrick K.; Yeo, Tomas; Aguiar, Anna C. C.; Angulo-Barturen, Inigo; Churchyard, Alisje; Baum, Jake; Fernandez, Benigno Crespo; Fuchs, Aline; Gamo, Francisco-Javier; Guido, Rafael V. C.; Jimenez-Diaz, Maria Belen; Pereira, Dhelio B.; Rochford, Rosemary; Roesch, Camille; Sanz, Laura M.; Trevitt, Graham; Witkowski, Benoit; Wittlin, Sergio; Cooper, Roland A.; Rosenthal, Philip J.; Sauerwein, Robert W.; Schalkwijk, Joost; Hermkens, Pedro H. H.; Bonnert, Roger, V; Campo, Brice; Fidock, David A.; Llinas, Manuel; Niles, Jacquin C.; Kooij, Taco W. A.; Dechering, Koen J.
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-08-2619
OAAI
Laleu, Benoit; Akao, Yuichiro; Ochida, Atsuko; Duffy, Sandra; Lucantoni, Leonardo; Shackleford, David M.; Chen, Gong; Katneni, Kasiram; Chiu, Francis C. K.; White, Karen L.; Chen, Xue; Sturm, Angelika; Dechering, Koen J.; Crespo, Benigno; Sanz, Laura M.; Wang, Binglin; Wittlin, Sergio; Charman, Susan A.; Avery, Vicky M.; Cho, Nobuo; Kamaura, Masahiro
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2021-07-2130
OA
Murithi, James M.; Pascal, Cecile; Bath, Jade; Boulenc, Xavier; Gnadig, Nina F.; Pasaje, Charisse Flerida A.; Rubiano, Kelly; Yeo, Tomas; Mok, Sachel; Klieber, Sylvie; Desert, Paul; Jimenez-Diaz, Maria Belen; Marfurt, Jutta; Rouillier, Melanie; Cherkaoui-Rbati, Mohammed H.; Gobeau, Nathalie; Wittlin, Sergio; Uhlemann, Anne-Catrin; Price, Ric N.; Wirjanata, Grennady; Noviyanti, Rintis; Tumwebaze, Patrick; Cooper, Roland A.; Rosenthal, Philip J.; Sanz, Laura M.; Gamo, Francisco Javier; Joseph, Jayan; Singh, Shivendra; Bashyam, Sridevi; Augereau, Jean Michel; Giraud, Elie; Bozec, Tanguy; Vermat, Thierry; Tuffal, Gilles; Guillon, Jean-Michel; Menegotto, Jerome; Salle, Laurent; Louit, Guillaume; Cabanis, Marie-Jose; Nicolas, Marie Francoise; Doubovetzky, Michel; Merino, Rita; Bessila, Nadir; Angulo-Barturen, Inigo; Baud, Delphine; Bebrevska, Lidiya; Escudie, Fanny; Niles, Jacquin C.; Blasco, Benjamin; Campbell, Simon; Courtemanche, Gilles; Fraisse, Laurent; Pellet, Alain; Fidock, David A.; Leroy, Didier
Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors
ACS INFECTIOUS DISEASES
IF3.8
2021-04-3018
OAAI
Okaniwa, Masanori; Shibata, Akira; Ochida, Atsuko; Akao, Yuichiro; White, Karen L.; Shackleford, David M.; Duffy, Sandra; Lucantoni, Leonardo; Dey, Sumanta; Striepen, Josefine; Yeo, Tomas; Mok, Sachel; Aguiar, Anna Caroline C.; Sturm, Angelika; Crespo, Benigno; Sanz, Laura M.; Churchyard, Alisje; Baum, Jake; Pereira, Dhelio B.; Guido, Rafael V. C.; Dechering, Koen J.; Wittlin, Sergio; Uhlemann, Anne-Catrin; Fidock, David A.; Niles, Jacquin C.; Avery, Vicky M.; Charman, Susan A.; Laleu, Benoit
Substituted Aminoacetamides as Novel Leads for Malaria Treatment
CHEMMEDCHEM
IF3.4
2019-07-036
OAAI
Norcross, Neil R.; Wilson, Caroline; Baragana, Beatriz; Hallyburton, Irene; Osuna-Cabello, Maria; Norval, Suzanne; Riley, Jennifer; Fletcher, Daniel; Sinden, Robert; Delves, Michael; Ruecker, Andrea; Duffy, Sandra; Meister, Stephan; Antonova-Koch, Yevgeniya; Crespo, Benigno; de Cozar, Cristina; Sanz, Laura M.; Javier Gamo, Francisco; Avery, Vicky M.; Frearson, Julie A.; Gray, David W.; Fairlamb, Alan H.; Winzeler, Elizabeth A.; Waterson, David; Campbell, Simon F.; Willis, Paul A.; Read, Kevin D.; Gilbert, Ian H.
Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
IF3.4
2019-04-0135
OAAI
Loesbanluechai, Duangkamon; Kotanan, Namfon; de Cozar, Cristina; Kochakarn, Theerarat; Ansbro, Megan R.; Chotivanich, Kesinee; White, Nicholas J.; Wilairat, Prapon; Lee, Marcus C. S.; Javier Gamo, Francisco; Maria Sanz, Laura; Chookajorn, Thanat; Kumpornsin, Krittikorn
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-03-20111
OAAI
Baragana, Beatriz; Forte, Barbara; Choi, Ryan; Hewitt, Stephen Nakazawa; Bueren-Calabuig, Juan A.; Pisco, Joao Pedro; Peet, Caroline; Dranow, David M.; Robinson, David A.; Jansen, Chimed; Norcross, Neil R.; Vinayak, Sumiti; Anderson, Mark; Brooks, Carrie F.; Cooper, Caitlin A.; Damerow, Sebastian; Delves, Michael; Dowers, Karen; Duffy, James; Edwards, Thomas E.; Hallyburton, Irene; Horst, BenjaminG.; Hulverson, Matthew A.; Ferguson, Liam; Belen Jimenez-Diaz, Maria; Jumani, Rajiv S.; Lorimer, Donald D.; Love, Melissa S.; Maher, Steven; Matthews, Holly; McNamara, Casew.; Miller, Peter; O'Neill, Sandra; Ojo, Kayode K.; Osuna-Cabello, Maria; Pinto, Erika; Post, John; Riley, Jennifer; Rottmann, Matthias; Sanz, Laura M.; Scullion, Paul; Sharma, Arvind; Shepherd, Sharon M.; Shishikura, Yoko; Simeons, Frederick R. C.; Stebbins, Erin E.; Stojanovski, Laste; Straschil, Ursula; Tamaki, Fabio K.; Tamjar, Jevgenia; Torrie, Leah S.; Vantaux, Amelie; Witkowski, Benoit; Wittlin, Sergio; Yogavel, Manickam; Zuccotto, Fabio; Angulo-Barturen, Inigo; Sinden, Robert; Baum, Jake; Gamo, Francisco-Javier; Maser, Pascal; Kyle, Dennis E.; Winzeler, Elizabeth A.; Myler, Peter J.; Wyatt, Paul G.; Floyd, David; Matthews, David; Sharmao, Amit; Striepen, Boris; Huston, Christopher D.; Gray, David W.; Fairlamb, Alan H.; Pisliakov, Andrei V.; Walpole, Chris; Read, Kevin D.; Van Voorhis, Wesley C.; Gilbert, Ian H.
Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

4-氨基-2-苯胺喹唑啉在体外和恶性疟原虫人源化nod-scid IL2Rγnull疟疾小鼠模型中对疟原虫和其他顶复门寄生虫的评估

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2019-03-0117
OAAI
Gilson, Paul R.; Nguyen, William; Poole, William A.; Teixeira, Jose E.; Thompson, Jennifer K.; Guo, Kaiyuan; Stewart, Rebecca J.; Ashton, Trent D.; White, Karen L.; Sanz, Laura M.; Gamo, Francisco-Javier; Charman, Susan A.; Wittlin, Sergio; Duffy, James; Tonkin, Christopher J.; Tham, Wai-Hong; Crabb, Brendan S.; Cooke, Brian M.; Huston, Christopher D.; Cowman, Alan F.; Sleebs, Brad E.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

抗疟蛋白酶体抑制剂揭示了亚基间相互作用和抗性适应性成本的附带敏感性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2018-07-0267
OAAI
Kirkman, Laura A.; Zhan, Wenhu; Visone, Joseph; Dziedziech, Alexis; Singh, Pradeep K.; Fan, Hao; Tong, Xinran; Bruzual, Igor; Hara, Ryoma; Kawasaki, Masanori; Imaeda, Toshihiro; Okamoto, Rei; Sato, Kenjiro; Michino, Mayako; Fernandez Alvaro, Elena; Guiang, Liselle F.; Sanz, Laura; Mota, Daniel J.; Govindasamy, Kavitha; Wang, Rong; Ling, Yan; Tumwebaze, Patrick K.; Sukenick, George; Shi, Lei; Vendome, Jeremie; Bhanot, Purnima; Rosenthal, Philip J.; Aso, Kazuyoshi; Foley, Michael A.; Cooper, Roland A.; Kafsack, Bjorn; Doggett, J. Stone; Nathan, Carl F.; Lin, Gang
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
NATURE COMMUNICATIONS
IF15.7
2017-09-05105
OAAI
Baker, David A.; Stewart, Lindsay B.; Large, Jonathan M.; Bowyer, Paul W.; Ansell, Keith H.; Jimenez-Diaz, Mar-A B.; El Bakkouri, Majida; Birchall, Kristian; Dechering, Koen J.; Bouloc, Nathalie S.; Coombs, Peter J.; Whalley, David; Harding, Denise J.; Smiljanic-Hurley, Ela; Wheldon, Mary C.; Walker, Eloise M.; Dessens, Johannes T.; Lafuente, Maria Jose; Sanz, Laura M.; Gamo, Francisco-Javier; Ferrer, Santiago B.; Hui, Raymond; Bousema, Teun; Angulo-Barturen, I. Igo; Merritt, Andy T.; Croft, Simon L.; Gutteridge, Winston E.; Kettleborough, Catherine A.; Osborne, Simon A.
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
NATURE COMMUNICATIONS
IF15.7
2017-05-2457
OAAI
O'Neill, Paul M.; Amewu, Richard K.; Charman, Susan A.; Sabbani, Sunil; Gnadig, Nina F.; Straimer, Judith; Fidock, David A.; Shore, Emma R.; Roberts, Natalie L.; Wong, Michael H. -L.; Hong, W. David; Pidathala, Chandrakala; Riley, Chris; Murphy, Ben; Aljayyoussi, Ghaith; Gamo, Francisco Javier; Sanz, Laura; Rodrigues, Janneth; Cortes, Carolina Gonzalez; Herreros, Esperanza; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Bazaga, Santiago Ferrer; Santos Martinez-Martinez, Maria; Campo, Brice; Sharma, Raman; Ryan, Eileen; Shackleford, David M.; Campbell, Simon; Smith, Dennis A.; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N.; Marfurt, Jutta; Palmer, Michael J.; Copple, Ian M.; Mercer, Amy E.; Ruecker, Andrea; Delves, Michael J.; Sinden, Robert E.; Siegl, Peter; Davies, Jill; Rochford, Rosemary; Kocken, Clemens H. M.; Zeeman, Anne-Marie; Nixon, Gemma L.; Biagini, Giancarlo A.; Ward, Stephen A.
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2017-04-26208
OAAI
Paquet, Tanya; Le Manach, Claire; Cabrera, Diego Gonzalez; Younis, Yassir; Henrich, Philipp P.; Abraham, Tara S.; Lee, Marcus C. S.; Basak, Rajshekhar; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Bantscheff, Marcus; Ruecker, Andrea; Blagborough, Andrew M.; Zakutansky, Sara E.; Zeeman, Anne-Marie; White, Karen L.; Shackleford, David M.; Mannila, Janne; Morizzi, Julia; Scheurer, Christian; Angulo-Barturen, Inigo; Martinez, Maria Santos; Ferrer, Santiago; Sanz, Laura Maria; Gamo, Francisco Javier; Reader, Janette; Botha, Mariette; Dechering, Koen J.; Sauerwein, Robert W.; Tungtaeng, Anchalee; Vanachayangkul, Pattaraporn; Lim, Chek Shik; Burrows, Jeremy; Witty, Michael J.; Marsh, Kennan C.; Bodenreider, Christophe; Rochford, Rosemary; Solapure, Suresh M.; Jimenez-Diaz, Mara Belen; Wittlin, Sergio; Charman, Susan A.; Donini, Cristina; Campo, Brice; Birkholtz, Lyn-Marie; Hanson, Kirsten K.; Drewes, Gerard; Kocken, Clemens H. M.; Delves, Michael J.; Leroy, Didier; Fidock, David A.; Waterson, David; Street, Leslie J.; Chibale, Kelly

研究方向

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Francisco‐Javier Gamo
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M
Marı́a Belén Jiménez-Dı́az
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Maria Santos Martínez
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S
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Santiago Ferrer
H 指数:34论文数:88被引数:5,048
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H 指数:95论文数:427被引数:3.3万
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Vicky M. Avery
H 指数:55论文数:371被引数:1.1万
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Sandra Duffy
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Susan A. Charman
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